PubMed

The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.

Prudente S, Hribal ML, Flex E, Turchi F, Morini E, De Cosmo S, Bacci S, Tassi V, Cardellini M, Lauro R, Sesti G, Dallapiccola B, Trischitta V.

Diabetes. 2005 Sep;54(9):2807-11.PMID: 16123373 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.

Shi Z, Liu J, Guo Q, Ma X, Shen L, Xu S, Gao H, Yuan X, Zhang J.

Endocrine. 2009 Jun;35(3):414-9. Epub 2009 Mar 17.PMID: 19291425 [PubMed - indexed for MEDLINE]Related articles

The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes.

Prudente S, Scarpelli D, Chandalia M, Zhang YY, Morini E, Del Guerra S, Perticone F, Li R, Powers C, Andreozzi F, Marchetti P, Dallapiccola B, Abate N, Doria A, Sesti G, Trischitta V.

J Clin Endocrinol Metab. 2009 Jan;94(1):190-6. Epub 2008 Nov 4.PMID: 18984671 [PubMed - indexed for MEDLINE]Related articles

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.

Du K, Herzig S, Kulkarni RN, Montminy M.

Science. 2003 Jun 6;300(5625):1574-7.PMID: 12791994 [PubMed - indexed for MEDLINE]Related articlesFree article

TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.

Andreozzi F, Formoso G, Prudente S, Hribal ML, Pandolfi A, Bellacchio E, Di Silvestre S, Trischitta V, Consoli A, Sesti G.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1355-60. Epub 2008 Apr 24.PMID: 18436806 [PubMed - indexed for MEDLINE]Related articlesFree article

The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.

Prudente S, Morini E, Trischitta V.

Acta Diabetol. 2009 Jun;46(2):79-84. Epub 2009 Jan 13. Review.PMID: 19139803 [PubMed - indexed for MEDLINE]Related articles

A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities.

Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, Spampinato D, Di Paola R, Cisternino C, Tassi V, Vigneri R, Pizzuti A, Trischitta V.

Diabetes. 2001 Aug;50(8):1952-5.PMID: 11473061 [PubMed - indexed for MEDLINE]Related articlesFree article

TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.

Gong HP, Wang ZH, Jiang H, Fang NN, Li JS, Shang YY, Zhang Y, Zhong M, Zhang W.

Diabetes Care. 2009 Jul;32(7):1311-3. Epub 2009 Apr 23.PMID: 19389818 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.

He L, Simmen FA, Mehendale HM, Ronis MJ, Badger TM.

J Biol Chem. 2006 Apr 21;281(16):11126-34. Epub 2006 Feb 1.PMID: 16452480 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.

Scarpelli D, Cardellini M, Andreozzi F, Laratta E, Hribal ML, Marini MA, Tassi V, Lauro R, Perticone F, Sesti G.

Diabetes. 2006 May;55(5):1529-33.PMID: 16644716 [PubMed - indexed for MEDLINE]Related articlesFree article

1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population.

Meshkani R, Taghikhani M, Mosapour A, Larijani B, Khatami S, Khoshbin E, Ahmadvand D, Saeidi P, Maleki A, Yavari K, Nasoohi N, Adeli K.

Arch Med Res. 2007 Jul;38(5):556-62. Epub 2007 Mar 23.PMID: 17560463 [PubMed - indexed for MEDLINE]Related articles

Human TRB3 is upregulated in stressed cells by the induction of translationally efficient mRNA containing a truncated 5'-UTR.

Ord T, Ord D, Kõivomägi M, Juhkam K, Ord T.

Gene. 2009 Sep 1;444(1-2):24-32. Epub 2009 Jun 6.PMID: 19505541 [PubMed - indexed for MEDLINE]Related articles

TRB3 interacts with CtIP and is overexpressed in certain cancers.

Xu J, Lv S, Qin Y, Shu F, Xu Y, Chen J, Xu BE, Sun X, Wu J.

Biochim Biophys Acta. 2007 Feb;1770(2):273-8. Epub 2006 Oct 18.PMID: 17112672 [PubMed - indexed for MEDLINE]Related articles

E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.

Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F.

Cell Signal. 2008 May;20(5):942-8. Epub 2008 Jan 24.PMID: 18276110 [PubMed - indexed for MEDLINE]Related articles

Double tribble: two TRIB3 variants, insulin, Akt, and eNOS.

Fleming I.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1216-8. No abstract available. PMID: 18565845 [PubMed - indexed for MEDLINE]Related articlesFree article

The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.

Bacci S, Ludovico O, Prudente S, Zhang YY, Di Paola R, Mangiacotti D, Rauseo A, Nolan D, Duffy J, Fini G, Salvemini L, Amico C, Vigna C, Pellegrini F, Menzaghi C, Doria A, Trischitta V.

Diabetes. 2005 Oct;54(10):3021-5.PMID: 16186408 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.

Okamoto H, Latres E, Liu R, Thabet K, Murphy A, Valenzeula D, Yancopoulos GD, Stitt TN, Glass DJ, Sleeman MW.

Diabetes. 2007 May;56(5):1350-6. Epub 2007 Feb 15.PMID: 17303803 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes.

De Cosmo S, Prudente S, Andreozzi F, Morini E, Rauseo A, Scarpelli D, Zhang YY, Xu R, Perticone F, Dallapiccola B, Sesti G, Doria A, Trischitta V.

Am J Kidney Dis. 2007 Oct;50(4):688-9. No abstract available. PMID: 17900474 [PubMed - indexed for MEDLINE]Related articles

Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians.

Menzaghi C, Coco A, Salvemini L, Thompson R, De Cosmo S, Doria A, Trischitta V.

J Clin Endocrinol Metab. 2006 Jul;91(7):2792-5. Epub 2006 May 2.PMID: 16670163 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits.

Craig RL, Chu WS, Elbein SC.

Mol Genet Metab. 2007 Mar;90(3):338-44. Epub 2006 Dec 14.PMID: 17174134 [PubMed - indexed for MEDLINE]Related articlesFree article