PubMed

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.

Kjørholt C, Akerfeldt MC, Biden TJ, Laybutt DR.

Diabetes. 2005 Sep;54(9):2755-63.PMID: 16123366 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC.

J Biol Chem. 2002 Mar 29;277(13):10912-21. Epub 2002 Jan 8.PMID: 11782487 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.

Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GC.

J Biol Chem. 1999 May 14;274(20):14112-21.PMID: 10318828 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.

Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC.

J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.PMID: 12438314 [PubMed - indexed for MEDLINE]Related articlesFree article

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats.

Harmon JS, Gleason CE, Tanaka Y, Poitout V, Robertson RP.

Diabetes. 2001 Nov;50(11):2481-6.PMID: 11679425 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.

Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC.

Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.PMID: 17641871 [PubMed - indexed for MEDLINE]Related articles

Role of oxidative stress in pancreatic beta-cell dysfunction.

Kajimoto Y, Kaneto H.

Ann N Y Acad Sci. 2004 Apr;1011:168-76.PMID: 15126294 [PubMed - indexed for MEDLINE]Related articles

Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.

Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC.

Diabetes. 2002 Feb;51(2):413-23.PMID: 11812749 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress.

Ishida H, Takizawa M, Ozawa S, Nakamichi Y, Yamaguchi S, Katsuta H, Tanaka T, Maruyama M, Katahira H, Yoshimoto K, Itagaki E, Nagamatsu S.

Metabolism. 2004 Apr;53(4):488-94.PMID: 15045697 [PubMed - indexed for MEDLINE]Related articles

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

Tozzo E, Ponticiello R, Swartz J, Farrelly D, Zebo R, Welzel G, Egan D, Kunselman L, Peters A, Gu L, French M, Chen S, Devasthale P, Janovitz E, Staal A, Harrity T, Belder R, Cheng PT, Whaley J, Taylor S, Hariharan N.

J Pharmacol Exp Ther. 2007 Apr;321(1):107-15. Epub 2007 Jan 26.PMID: 17259449 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes.

Chu KY, Lau T, Carlsson PO, Leung PS.

Diabetes. 2006 Feb;55(2):367-74.PMID: 16443769 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.

Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ.

Diabetologia. 2007 Apr;50(4):752-63. Epub 2007 Feb 1.PMID: 17268797 [PubMed - indexed for MEDLINE]Related articles

Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.

Garris DR, Garris BL.

Cell Tissue Res. 2005 Feb;319(2):231-42. Epub 2004 Nov 20.PMID: 15654653 [PubMed - indexed for MEDLINE]Related articles

The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment.

Thorens B, Wu YJ, Leahy JL, Weir GC.

J Clin Invest. 1992 Jul;90(1):77-85.PMID: 1634622 [PubMed - indexed for MEDLINE]Related articlesFree article

Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans.

Srivastava M, Eidelman O, Leighton X, Glasman M, Goping G, Pollard HB.

Mol Med. 2002 Dec;8(12):781-97.PMID: 12606813 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED.

Endocrinology. 2005 Dec;146(12):5341-9. Epub 2005 Sep 1.PMID: 16141388 [PubMed - indexed for MEDLINE]Related articlesFree article

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD.

Genome Res. 2008 May;18(5):706-16. Epub 2008 Mar 17.PMID: 18347327 [PubMed - indexed for MEDLINE]Related articlesFree article

Nkx2.2 regulates beta-cell function in the mature islet.

Doyle MJ, Sussel L.

Diabetes. 2007 Aug;56(8):1999-2007. Epub 2007 Apr 24.PMID: 17456846 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells.

Jonas JC, Laybutt DR, Steil GM, Trivedi N, Pertusa JG, Van de Casteele M, Weir GC, Henquin JC.

J Biol Chem. 2001 Sep 21;276(38):35375-81. Epub 2001 Jul 16.PMID: 11457846 [PubMed - indexed for MEDLINE]Related articlesFree article

[Potential role of the early response gene c-Myc in the loss of differentiation and function of pancreatic beta cells submitted to chronic hyperglycemia]

Jonas JC.

Bull Mem Acad R Med Belg. 2001;156(6 Pt 2):297-301. French. PMID: 11928219 [PubMed - indexed for MEDLINE]Related articles