PubMed

Transgenic mouse overexpressing syntaxin-1A as a diabetes model.

Lam PP, Leung YM, Sheu L, Ellis J, Tsushima RG, Osborne LR, Gaisano HY.

Diabetes. 2005 Sep;54(9):2744-54.PMID: 16123365 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.

Xia F, Leung YM, Gaisano G, Gao X, Chen Y, Fox JE, Bhattacharjee A, Wheeler MB, Gaisano HY, Tsushima RG.

Endocrinology. 2007 May;148(5):2157-67. Epub 2007 Feb 15.PMID: 17303668 [PubMed - indexed for MEDLINE]Related articlesFree article

SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.

Leung YM, Kwan EP, Ng B, Kang Y, Gaisano HY.

Endocr Rev. 2007 Oct;28(6):653-63. Epub 2007 Sep 18. Review.PMID: 17878408 [PubMed - indexed for MEDLINE]Related articlesFree article

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.

Cui N, Kang Y, He Y, Leung YM, Xie H, Pasyk EA, Gao X, Sheu L, Hansen JB, Wahl P, Tsushima RG, Gaisano HY.

J Biol Chem. 2004 Dec 17;279(51):53259-65. Epub 2004 Oct 13.PMID: 15485808 [PubMed - indexed for MEDLINE]Related articlesFree article

Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels.

Wolf-Goldberg T, Michaelevski I, Sheu L, Gaisano HY, Chikvashvili D, Lotan I.

Mol Pharmacol. 2006 Sep;70(3):818-28. Epub 2006 Jun 5.PMID: 16754785 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse.

Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, Gaisano HY.

Endocrinology. 2005 Nov;146(11):4766-75. Epub 2005 Aug 18.PMID: 16109783 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis.

Xia F, Gao X, Kwan E, Lam PP, Chan L, Sy K, Sheu L, Wheeler MB, Gaisano HY, Tsushima RG.

J Biol Chem. 2004 Jun 4;279(23):24685-91. Epub 2004 Apr 8.PMID: 15073181 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG.

Endocrinology. 2008 Oct;149(10):5136-45. Epub 2008 Jul 3.PMID: 18599549 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion.

Nagamatsu S, Nakamichi Y, Yamamura C, Matsushima S, Watanabe T, Ozawa S, Furukawa H, Ishida H.

Diabetes. 1999 Dec;48(12):2367-73.PMID: 10580425 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.

MacDonald PE, Wang G, Tsuk S, Dodo C, Kang Y, Tang L, Wheeler MB, Cattral MS, Lakey JR, Salapatek AM, Lotan I, Gaisano HY.

Mol Endocrinol. 2002 Nov;16(11):2452-61.PMID: 12403834 [PubMed - indexed for MEDLINE]Related articlesFree article

The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

Ng B, Kang Y, Elias CL, He Y, Xie H, Hansen JB, Wahl P, Gaisano HY.

Diabetes. 2007 Aug;56(8):2124-34. Epub 2007 May 11.PMID: 17496234 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.

Ribar TJ, Jan CR, Augustine GJ, Means AR.

J Biol Chem. 1995 Dec 1;270(48):28688-95.PMID: 7499389 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and functional role of syntaxin 1/HPC-1 in pancreatic beta cells. Syntaxin 1A, but not 1B, plays a negative role in regulatory insulin release pathway.

Nagamatsu S, Fujiwara T, Nakamichi Y, Watanabe T, Katahira H, Sawa H, Akagawa K.

J Biol Chem. 1996 Jan 12;271(2):1160-5.PMID: 8557645 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment.

Gaisano HY, Ostenson CG, Sheu L, Wheeler MB, Efendic S.

Endocrinology. 2002 Nov;143(11):4218-26.PMID: 12399415 [PubMed - indexed for MEDLINE]Related articlesFree article

Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.

Leung YM, Kang Y, Gao X, Xia F, Xie H, Sheu L, Tsuk S, Lotan I, Tsushima RG, Gaisano HY.

J Biol Chem. 2003 May 9;278(19):17532-8. Epub 2003 Mar 5.PMID: 12621036 [PubMed - indexed for MEDLINE]Related articlesFree article

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines.

Kang Y, Huang X, Pasyk EA, Ji J, Holz GG, Wheeler MB, Tsushima RG, Gaisano HY.

Diabetologia. 2002 Feb;45(2):231-41.PMID: 11935155 [PubMed - indexed for MEDLINE]Related articles

Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P.

J Physiol. 2004 May 1;556(Pt 3):711-26. Epub 2004 Feb 13.PMID: 14966302 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats.

Hughes SJ, Faehling M, Thorneley CW, Proks P, Ashcroft FM, Smith PA.

Diabetes. 1998 Jan;47(1):73-81.PMID: 9421377 [PubMed - indexed for MEDLINE]Related articles

Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25.

Ji J, Yang SN, Huang X, Li X, Sheu L, Diamant N, Berggren PO, Gaisano HY.

Diabetes. 2002 May;51(5):1425-36.PMID: 11978639 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG.

Nat Genet. 2000 Nov;26(3):336-40.PMID: 11062475 [PubMed - indexed for MEDLINE]Related articles