PubMed

Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells.

Kim WH, Lee JW, Suh YH, Hong SH, Choi JS, Lim JH, Song JH, Gao B, Jung MH.

Diabetes. 2005 Sep;54(9):2602-11.PMID: 16123348 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells.

Lee JW, Kim WH, Lim JH, Song EH, Song J, Choi KY, Jung MH.

Cell Signal. 2009 Jan;21(1):69-78. Epub 2008 Oct 7.PMID: 18940247 [PubMed - indexed for MEDLINE]Related articles

AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis.

Kim WH, Lee JW, Suh YH, Lee HJ, Lee SH, Oh YK, Gao B, Jung MH.

Cell Signal. 2007 Apr;19(4):791-805. Epub 2006 Nov 28.PMID: 17127032 [PubMed - indexed for MEDLINE]Related articles

Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells.

Joe MK, Lee HJ, Suh YH, Han KL, Lim JH, Song J, Seong JK, Jung MH.

Cell Signal. 2008 May;20(5):907-15. Epub 2008 Jan 18.PMID: 18289831 [PubMed - indexed for MEDLINE]Related articles

Methylmercury induces pancreatic beta-cell apoptosis and dysfunction.

Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.

Chem Res Toxicol. 2006 Aug;19(8):1080-5.PMID: 16918248 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction.

Kooptiwut S, Kebede M, Zraika S, Visinoni S, Aston-Mourney K, Favaloro J, Tikellis C, Thomas MC, Forbes JM, Cooper ME, Dunlop M, Proietto J, Andrikopoulos S.

J Mol Endocrinol. 2005 Aug;35(1):39-48.PMID: 16087720 [PubMed - indexed for MEDLINE]Related articlesFree article

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE.

Diabetes. 2006 Aug;55(8):2212-9.PMID: 16873683 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T.

J Clin Invest. 2007 Jan;117(1):246-57.PMID: 17200721 [PubMed - indexed for MEDLINE]Related articlesFree article

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines.

Wu L, Nicholson W, Knobel SM, Steffner RJ, May JM, Piston DW, Powers AC.

J Biol Chem. 2004 Mar 26;279(13):12126-34. Epub 2003 Dec 19.PMID: 14688272 [PubMed - indexed for MEDLINE]Related articlesFree article

Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.

Radu RG, Fujimoto S, Mukai E, Takehiro M, Shimono D, Nabe K, Shimodahira M, Kominato R, Aramaki Y, Nishi Y, Funakoshi S, Yamada Y, Seino Y.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E365-71. Epub 2004 Oct 12.PMID: 15479952 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):937-44.PMID: 14651961 [PubMed - indexed for MEDLINE]Related articles

Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.

Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL.

J Endocrinol. 2007 Jun;193(3):367-81.PMID: 17535875 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R.

FASEB J. 2008 Jun;22(6):1905-13. Epub 2008 Feb 8.PMID: 18263705 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.

Collier JJ, Fueger PT, Hohmeier HE, Newgard CB.

Diabetes. 2006 May;55(5):1398-406.PMID: 16644697 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates.

German MS.

Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1781-5.PMID: 8446591 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo.

Päth G, Opel A, Gehlen M, Rothhammer V, Niu X, Limbert C, Romfeld L, Hügl S, Knoll A, Brendel MD, Bretzel RG, Seufert J.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1168-76. Epub 2006 Jul 5.PMID: 16822955 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells.

Wei P, Shi M, Barnum S, Cho H, Carlson T, Fraser JD.

Diabetologia. 2009 Oct;52(10):2142-50. Epub 2009 Jul 30.PMID: 19641898 [PubMed - in process]Related articles