PubMed

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.

Holland AM, Góñez LJ, Naselli G, Macdonald RJ, Harrison LC.

Diabetes. 2005 Sep;54(9):2586-95.PMID: 16123346 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.

Koya V, Lu S, Sun YP, Purich DL, Atkinson MA, Li SW, Yang LJ.

Diabetes. 2008 Mar;57(3):757-69. Epub 2007 Dec 17.PMID: 18086901 [PubMed - indexed for MEDLINE]Related articlesFree article

Experimental control of pancreatic development and maintenance.

Holland AM, Hale MA, Kagami H, Hammer RE, MacDonald RJ.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12236-41. Epub 2002 Sep 9.PMID: 12221286 [PubMed - indexed for MEDLINE]Related articlesFree article

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells.

Lottmann H, Vanselow J, Hessabi B, Walther R.

J Mol Med. 2001 Jun;79(5-6):321-8.PMID: 11485027 [PubMed - indexed for MEDLINE]Related articles

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D.

J Clin Invest. 2002 Dec;110(12):1839-47.PMID: 12488434 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

Li Y, Cao X, Li LX, Brubaker PL, Edlund H, Drucker DJ.

Diabetes. 2005 Feb;54(2):482-91.PMID: 15677506 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH.

Diabetes. 2002 Aug;51(8):2546-51.PMID: 12145169 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.

Wang H, Maechler P, Ritz-Laser B, Hagenfeldt KA, Ishihara H, Philippe J, Wollheim CB.

J Biol Chem. 2001 Jul 6;276(27):25279-86. Epub 2001 Apr 17.PMID: 11309388 [PubMed - indexed for MEDLINE]Related articles

Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.

Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ Jr, Wright CV, Leach SD.

Gastroenterology. 1999 Dec;117(6):1416-26.PMID: 10579983 [PubMed - indexed for MEDLINE]Related articles

Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.

Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV.

Development. 2000 Jul;127(13):2883-95.PMID: 10851133 [PubMed - indexed for MEDLINE]Related articlesFree article

The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity.

Boucher MJ, Simoneau M, Edlund H.

Endocrinology. 2009 Jan;150(1):87-97. Epub 2008 Sep 4.PMID: 18772243 [PubMed - indexed for MEDLINE]Related articles

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.

Gannon M, Gamer LW, Wright CV.

Dev Biol. 2001 Oct 1;238(1):185-201.PMID: 11784003 [PubMed - indexed for MEDLINE]Related articles

Pdx1 restores beta cell function in Irs2 knockout mice.

Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF.

J Clin Invest. 2002 May;109(9):1193-201.PMID: 11994408 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R, Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T.

J Biol Chem. 2003 Oct 31;278(44):43691-8. Epub 2003 Jul 16.PMID: 12869553 [PubMed - indexed for MEDLINE]Related articlesFree article

An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).

Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM, Wright CV, MacDonald RJ.

Mol Cell Biol. 1998 Sep;18(9):5109-20.PMID: 9710595 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the pdx1 gene promoter in pancreatic beta-cells.

Campbell SC, Macfarlane WM.

Biochem Biophys Res Commun. 2002 Nov 29;299(2):277-84.PMID: 12437983 [PubMed - indexed for MEDLINE]Related articles

Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors.

Serafimidis I, Rakatzi I, Episkopou V, Gouti M, Gavalas A.

Stem Cells. 2008 Jan;26(1):3-16. Epub 2007 Oct 11.PMID: 17932425 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt/beta-catenin signaling is required for development of the exocrine pancreas.

Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM.

BMC Dev Biol. 2007 Jan 12;7:4.PMID: 17222338 [PubMed - indexed for MEDLINE]Related articlesFree article

The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas.

Hale MA, Kagami H, Shi L, Holland AM, Elsässer HP, Hammer RE, MacDonald RJ.

Dev Biol. 2005 Oct 1;286(1):225-37.PMID: 16126192 [PubMed - indexed for MEDLINE]Related articles

Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.

Svensson P, Williams C, Lundeberg J, Rydén P, Bergqvist I, Edlund H.

BMC Dev Biol. 2007 Nov 23;7:129.PMID: 18036209 [PubMed - indexed for MEDLINE]Related articlesFree article