PubMed

Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.

Veluthakal R, Chvyrkova I, Tannous M, McDonald P, Amin R, Hadden T, Thurmond DC, Quon MJ, Kowluru A.

Diabetes. 2005 Sep;54(9):2576-85.PMID: 16123345 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells.

Chen HQ, Tannous M, Veluthakal R, Amin R, Kowluru A.

Biochem Pharmacol. 2003 Nov 1;66(9):1681-94.PMID: 14563479 [PubMed - indexed for MEDLINE]Related articles

IL-1beta-induced nitric oxide release from insulin-secreting beta-cells: further evidence for the involvement of GTP-binding proteins.

Tannous M, Veluthakal R, Amin R, Kowluru A.

Diabetes Metab. 2002 Dec;28(6 Pt 2):3S78-84; discussion 3S108-12.PMID: 12688637 [PubMed - indexed for MEDLINE]Related articles

Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide.

Arafat HA, Katakam AK, Chipitsyna G, Gong Q, Vancha AR, Gabbeta J, Dafoe DC.

Endocrinology. 2007 Feb;148(2):575-84. Epub 2006 Nov 16.PMID: 17110428 [PubMed - indexed for MEDLINE]Related articlesFree article

Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells.

Tannous M, Amin R, Popoff MR, Fiorentini C, Kowluru A.

Biochem Pharmacol. 2001 Dec 1;62(11):1459-68.PMID: 11728382 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells.

Chen MC, Paez-Espinosa V, Welsh N, Eizirik DL.

Endocrinology. 2000 Aug;141(8):2822-8.PMID: 10919268 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of Rho-associated kinase in differential regulation by statins of interleukin-1beta- and lipopolysaccharide-mediated nuclear factor kappaB activation and inducible nitric-oxide synthase gene expression in vascular smooth muscle cells.

Wei CY, Huang KC, Chou YH, Hsieh PF, Lin KH, Lin WW.

Mol Pharmacol. 2006 Mar;69(3):960-7. Epub 2005 Nov 29.PMID: 16317111 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells.

Susick L, Veluthakal R, Suresh MV, Hadden T, Kowluru A.

J Cell Mol Med. 2008 Sep-Oct;12(5A):1571-83. Epub 2007 Dec 5.PMID: 18053091 [PubMed - indexed for MEDLINE]Related articles

The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells.

Emanuelli B, Glondu M, Filloux C, Peraldi P, Van Obberghen E.

Diabetes. 2004 Dec;53 Suppl 3:S97-S103.PMID: 15561930 [PubMed - indexed for MEDLINE]Related articlesFree article

Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.

Kim EK, Kwon KB, Song MY, Han MJ, Lee JH, Lee YR, Lee JH, Ryu DG, Park BH, Park JW.

Pancreas. 2007 Nov;35(4):e1-9.PMID: 18090225 [PubMed - indexed for MEDLINE]Related articles

Distinction between signaling mechanisms in lipid rafts vs. caveolae.

Sowa G, Pypaert M, Sessa WC.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14072-7. Epub 2001 Nov 13.PMID: 11707586 [PubMed - indexed for MEDLINE]Related articlesFree article

PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells.

Ginnan R, Guikema BJ, Singer HA, Jourd'heuil D.

Am J Physiol Cell Physiol. 2006 Jun;290(6):C1583-91. Epub 2006 Jan 25.PMID: 16436473 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

Holohan C, Szegezdi E, Ritter T, O'Brien T, Samali A.

J Cell Mol Med. 2008 Apr;12(2):591-606. Epub 2007 Dec 10.PMID: 18081694 [PubMed - indexed for MEDLINE]Related articles

IL-1beta-induced iNOS expression, NO release and loss in metabolic cell viability are resistant to inhibitors of ceramide synthase and sphingomyelinase in INS 832/13 cells.

Veluthakal R, Jangati GR, Kowluru A.

JOP. 2006 Nov 10;7(6):593-601.PMID: 17095838 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-1beta swiftly down-regulates UCP-2 mRNA in beta-cells by mechanisms not directly coupled to toxicity.

Li LX, Yoshikawa H, Egeberg KW, Grill V.

Cytokine. 2003 Aug 21-Sep 7;23(4-5):101-7.PMID: 12967645 [PubMed - indexed for MEDLINE]Related articles

GTP-binding protein-independent potentiation by mastoparan of IL-1beta-induced nitric oxide release from insulin-secreting HIT-T15 cells.

Chen HQ, Veluthakal R, Palanivel R, Kowluru A.

Apoptosis. 2004 Mar;9(2):145-8.PMID: 15004511 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells.

Veluthakal R, Amin R, Kowluru A.

Am J Physiol Cell Physiol. 2004 Oct;287(4):C1152-62. Epub 2004 Jun 16.PMID: 15201138 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell.

Veluthakal R, Palanivel R, Zhao Y, McDonald P, Gruber S, Kowluru A.

Apoptosis. 2005 Aug;10(4):841-50.PMID: 16133874 [PubMed - indexed for MEDLINE]Related articles

Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans.

Scarim AL, Arnush M, Hill JR, Marshall CA, Baldwin A, McDaniel ML, Corbett JA.

Biochim Biophys Acta. 1997 Oct 24;1361(3):313-20.PMID: 9375806 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1beta signals through a c-Jun N-terminal kinase-dependent inducible nitric oxide synthase and nitric oxide production pathway in Sertoli epithelial cells.

Ishikawa T, Morris PL.

Endocrinology. 2006 Nov;147(11):5424-30. Epub 2006 Aug 3.PMID: 16887914 [PubMed - indexed for MEDLINE]Related articlesFree article