PubMed

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver.

Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK.

Diabetes. 2005 Sep;54(9):2514-24.PMID: 16123338 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice.

Ide T, Tsunoda M, Mochizuki T, Murakami K.

Med Sci Monit. 2004 Oct;10(10):BR388-95. Epub 2004 Sep 23.PMID: 15448592 [PubMed - indexed for MEDLINE]Related articles

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.

Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E30-9. Epub 2005 Feb 8.PMID: 15701680 [PubMed - indexed for MEDLINE]Related articlesFree article

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.

Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP.

Cell Metab. 2005 Feb;1(2):133-44.PMID: 16054054 [PubMed - indexed for MEDLINE]Related articles

Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.

Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP.

Circulation. 2007 Feb 20;115(7):909-17. Epub 2007 Jan 29.PMID: 17261654 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.PMID: 18952837 [PubMed - indexed for MEDLINE]Related articlesFree article

Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.

Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P.

Circulation. 2004 Nov 16;110(20):3259-69. Epub 2004 Nov 8.PMID: 15533870 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart.

Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, Shoghi K, Welch MJ, Kelly DP.

J Clin Invest. 2007 Dec;117(12):3930-9.PMID: 18037994 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase.

Campbell FM, Kozak R, Wagner A, Altarejos JY, Dyck JR, Belke DD, Severson DL, Kelly DP, Lopaschuk GD.

J Biol Chem. 2002 Feb 8;277(6):4098-103. Epub 2001 Dec 4.PMID: 11734553 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED.

Endocrinology. 2005 Dec;146(12):5341-9. Epub 2005 Sep 1.PMID: 16141388 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis.

Qiu L, Wu X, Chau JF, Szeto IY, Tam WY, Guo Z, Chung SK, Oates PJ, Chung SS, Yang JY.

J Biol Chem. 2008 Jun 20;283(25):17175-83. Epub 2008 Apr 29.PMID: 18445591 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance.

Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7522-7. Epub 2001 Jun 5.PMID: 11390966 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice.

Aasum E, Cooper M, Severson DL, Larsen TS.

Can J Physiol Pharmacol. 2005 Feb;83(2):183-90.PMID: 15791292 [PubMed - indexed for MEDLINE]Related articles

Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss.

Hafstad AD, Khalid AM, Hagve M, Lund T, Larsen TS, Severson DL, Clarke K, Berge RK, Aasum E.

Cardiovasc Res. 2009 Aug 1;83(3):519-26. Epub 2009 Apr 27.PMID: 19398469 [PubMed - indexed for MEDLINE]Related articles

Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.

Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi JM.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E357-64. Epub 2007 Nov 27.PMID: 18042664 [PubMed - indexed for MEDLINE]Related articlesFree article

Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.

Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E536-43. Epub 2006 Apr 18. Erratum in: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E370. PMID: 16621898 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity.

Dewald O, Sharma S, Adrogue J, Salazar R, Duerr GD, Crapo JD, Entman ML, Taegtmeyer H.

Circulation. 2005 Jul 19;112(3):407-15. Epub 2005 Jul 11.PMID: 16009788 [PubMed - indexed for MEDLINE]Related articlesFree article

CD36 deficiency rescues lipotoxic cardiomyopathy.

Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, Febbraio M, Finck BN, Kelly DP.

Circ Res. 2007 Apr 27;100(8):1208-17. Epub 2007 Mar 15.PMID: 17363697 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart JC, Kuipers F, Pattou F, Fiévet C, Staels B.

Diabetes. 2006 Jun;55(6):1605-13.PMID: 16731822 [PubMed - indexed for MEDLINE]Related articlesFree article

Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice.

Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, Lee MK, Dey A, Rothermel B, Kim YB, Kalinowski A, Russell KS, Kim JK.

Diabetes. 2005 Dec;54(12):3530-40.PMID: 16306372 [PubMed - indexed for MEDLINE]Related articlesFree article