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Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.
Diabetes. 2005 Aug;54(8):2396-403.PMID: 16046307 [PubMed - indexed for MEDLINE]Related articlesFree article
Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.
Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.
Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.PMID: 17473223 [PubMed - indexed for MEDLINE]Related articlesFree article
Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction.
Gysemans CA, Pavlovic D, Bouillon R, Eizirik DL, Mathieu C.
Diabetologia. 2001 May;44(5):567-74.PMID: 11380074 [PubMed - indexed for MEDLINE]Related articles
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article
SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma.
Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B.
J Biol Chem. 2001 Jul 13;276(28):25862-70. Epub 2001 May 7.PMID: 11342558 [PubMed - indexed for MEDLINE]Related articlesFree article
The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.
Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.
Eur Cytokine Netw. 1999 Sep;10(3):403-12.PMID: 10477397 [PubMed - indexed for MEDLINE]Related articles
Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1-induced inducible nitric-oxide synthase expression by islets of Langerhans.
Heitmeier MR, Scarim AL, Corbett JA.
J Biol Chem. 1999 Oct 8;274(41):29266-73.PMID: 10506184 [PubMed - indexed for MEDLINE]Related articlesFree article
Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines.
Chen G, Hohmeier HE, Newgard CB.
J Biol Chem. 2001 Jan 5;276(1):766-72.PMID: 11024034 [PubMed - indexed for MEDLINE]Related articlesFree article
IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death.
Suk K, Kim S, Kim YH, Kim KA, Chang I, Yagita H, Shong M, Lee MS.
J Immunol. 2001 Apr 1;166(7):4481-9.PMID: 11254704 [PubMed - indexed for MEDLINE]Related articlesFree article
Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.
Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B.
J Biol Chem. 2000 Dec 1;275(48):37672-8.PMID: 10967106 [PubMed - indexed for MEDLINE]Related articlesFree article
Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.
Chong MM, Thomas HE, Kay TW.
J Biol Chem. 2002 Aug 2;277(31):27945-52. Epub 2002 May 24.PMID: 12032139 [PubMed - indexed for MEDLINE]Related articlesFree article
Cytokine signalling in the beta-cell: a dual role for IFNgamma.
Gysemans C, Callewaert H, Overbergh L, Mathieu C.
Biochem Soc Trans. 2008 Jun;36(Pt 3):328-33. Review.PMID: 18481951 [PubMed - indexed for MEDLINE]Related articles
Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.
Liu D, Darville M, Eizirik DL.
Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article
Silymarin protects pancreatic beta-cells against cytokine-mediated toxicity: implication of c-Jun NH2-terminal kinase and janus kinase/signal transducer and activator of transcription pathways.
Matsuda T, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y.
Endocrinology. 2005 Jan;146(1):175-85. Epub 2004 Sep 30.PMID: 15459112 [PubMed - indexed for MEDLINE]Related articlesFree article
cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells.
Diabetes. 2002 Jun;51(6):1805-14.PMID: 12031968 [PubMed - indexed for MEDLINE]Related articlesFree article
Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase.
Andersson AK, Flodström M, Sandler S.
Biochem Biophys Res Commun. 2001 Feb 23;281(2):396-403.PMID: 11181061 [PubMed - indexed for MEDLINE]Related articles
Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production.
Thomas HE, Darwiche R, Corbett JA, Kay TW.
Diabetes. 2002 Feb;51(2):311-6.PMID: 11812737 [PubMed - indexed for MEDLINE]Related articlesFree article
STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.
Jensen J, Galsgaard ED, Karlsen AE, Lee YC, Nielsen JH.
J Endocrinol. 2005 Oct;187(1):25-36.PMID: 16214938 [PubMed - indexed for MEDLINE]Related articlesFree article
gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1.
Diabetes. 2001 Dec;50(12):2744-51.PMID: 11723057 [PubMed - indexed for MEDLINE]Related articlesFree article
Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
Hong TP, Andersen NA, Nielsen K, Karlsen AE, Fantuzzi G, Eizirik DL, Dinarello CA, Mandrup-Poulsen T.
Eur Cytokine Netw. 2000 Jun;11(2):193-205.PMID: 10903798 [PubMed - indexed for MEDLINE]Related articles
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