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    Results: 1 to 20 of 150

    1.

    Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.

    Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.

    Diabetes. 2005 Aug;54(8):2351-9.PMID: 16046301 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.

    Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB.

    Diabetes. 2003 Aug;52(8):1935-42.PMID: 12882908 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

    Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB.

    Diabetes. 1999 Feb;48(2):310-20.PMID: 10334307 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.

    Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV.

    Diabetes. 2003 Aug;52(8):1926-34.PMID: 12882907 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.

    Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB.

    J Clin Invest. 1999 Sep;104(6):733-41.PMID: 10491408 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

    Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV.

    Diabetes. 2002 Oct;51(10):2936-43.PMID: 12351430 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

    Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV.

    Diabetologia. 2006 Feb;49(2):375-82. Epub 2006 Jan 5.PMID: 16395615 [PubMed - indexed for MEDLINE]Related articles

    8.

    Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

    Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

    Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

    Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

    J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

    Shao J, Yamashita H, Qiao L, Friedman JE.

    J Endocrinol. 2000 Oct;167(1):107-15.PMID: 11018758 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.

    Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.

    Endocrinology. 2004 Jun;145(6):2845-57. Epub 2004 Mar 4.PMID: 15001544 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.

    Dokken BB, Sloniger JA, Henriksen EJ.

    Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1188-94. Epub 2005 Jan 25.PMID: 15671078 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

    Song XM, Kawano Y, Krook A, Ryder JW, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR.

    Diabetes. 1999 Mar;48(3):664-70.PMID: 10078575 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities.

    Tremblay F, Lavigne C, Jacques H, Marette A.

    Diabetes. 2001 Aug;50(8):1901-10.PMID: 11473054 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

    Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG.

    Life Sci. 2005 Oct 28;77(24):3068-77. Epub 2005 Jun 27.PMID: 15982669 [PubMed - indexed for MEDLINE]Related articles

    16.

    Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.

    Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM.

    J Clin Endocrinol Metab. 2002 Jan;87(1):226-34.PMID: 11788651 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.

    Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G.

    Circ Res. 2004 May 14;94(9):1211-8. Epub 2004 Mar 25.PMID: 15044323 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance.

    Vollenweider P, Ménard B, Nicod P.

    Diabetes. 2002 Apr;51(4):1052-9.PMID: 11916925 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

    Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

    J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway.

    Li G, Barrett EJ, Barrett MO, Cao W, Liu Z.

    Endocrinology. 2007 Jul;148(7):3356-63. Epub 2007 Apr 19.PMID: 17446186 [PubMed - indexed for MEDLINE]Related articlesFree article

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