PubMed

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.PMID: 16046294 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. Epub 2009 Mar 18.PMID: 19294363 [PubMed - indexed for MEDLINE]Related articles

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS.

Diabetes. 1998 Mar;47(3):358-64.PMID: 9519740 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats.

Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, Leahy JL.

Diabetologia. 2001 Nov;44(11):2056-65.PMID: 11719838 [PubMed - indexed for MEDLINE]Related articles

Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.

Cockburn BN, Ostrega DM, Sturis J, Kubstrup C, Polonsky KS, Bell GI.

Diabetes. 1997 Sep;46(9):1434-9.PMID: 9287043 [PubMed - indexed for MEDLINE]Related articles

Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. Epub 2008 Jan 29.PMID: 18230696 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

Dickson LM, Rhodes CJ.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E192-8. Review.PMID: 15271644 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.

Diabetologia. 2006 Sep;49(9):2120-30. Epub 2006 Jul 26.PMID: 16868750 [PubMed - indexed for MEDLINE]Related articles

Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats.

Rafacho A, Ribeiro DL, Boschero AC, Taboga SR, Bosqueiro JR.

Int J Exp Pathol. 2008 Aug;89(4):264-75. Epub 2008 Apr 21.PMID: 18429991 [PubMed - indexed for MEDLINE]Related articles

Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.

Zhou YP, Cockburn BN, Pugh W, Polonsky KS.

Metabolism. 1999 Jul;48(7):857-64.PMID: 10421226 [PubMed - indexed for MEDLINE]Related articles

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.

Liu YQ, Jetton TL, Leahy JL.

J Biol Chem. 2002 Oct 18;277(42):39163-8. Epub 2002 Jul 29.PMID: 12147706 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals.

Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C.

Circ Res. 2005 Sep 30;97(7):725-33. Epub 2005 Aug 25.PMID: 16123336 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.

Ogino T, Zhu M, Murakami T, Kuwajima M, Shima K.

J Med Invest. 1998 Aug;45(1-4):103-10.PMID: 9864970 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL.

Diabetes. 2006 Dec;55(12):3289-98.PMID: 17130472 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.

Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG.

J Clin Invest. 2003 Jul;112(2):197-208. Epub 2003 Jul 3.PMID: 12843127 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes of islet size and islet size distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats.

Tse EO, Gregoire FM, Reusens B, Remacle C, Hoet JJ, Johnson PR, Stern JS.

Obes Res. 1997 Nov;5(6):563-71.PMID: 9449141 [PubMed - indexed for MEDLINE]Related articles

Insulin-secreting beta-cell dysfunction induced by human lipoproteins.

Roehrich ME, Mooser V, Lenain V, Herz J, Nimpf J, Azhar S, Bideau M, Capponi A, Nicod P, Haefliger JA, Waeber G.

J Biol Chem. 2003 May 16;278(20):18368-75. Epub 2003 Feb 18.PMID: 12594227 [PubMed - indexed for MEDLINE]Related articlesFree article

Hydrolysed casein diet protects BB rats from developing diabetes by promoting islet neogenesis.

Wang GS, Gruber H, Smyth P, Pulido O, Rosenberg L, Duguid W, Scott FW.

J Autoimmun. 2000 Dec;15(4):407-16.PMID: 11090239 [PubMed - indexed for MEDLINE]Related articles

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.

Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, Furth EE, Polonsky KS, Naji A, Birnbaum MJ.

Nat Med. 2001 Oct;7(10):1133-7.PMID: 11590437 [PubMed - indexed for MEDLINE]Related articles

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.

Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR.

J Clin Invest. 2004 Sep;114(6):828-36.PMID: 15372107 [PubMed - indexed for MEDLINE]Related articlesFree article