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Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study.

Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M, Cantu D, Gonzalez-Fierro A, Garcia-Lopez P, Zambrano P, Perez-Plasencia C, Cabrera G, Trejo-Becerril C, Angeles E, Duenas-Gonzalez A.

Mol Cancer. 2005 Jul 7;4(1):22.PMID: 16001982 [PubMed - indexed for MEDLINE]Related articlesFree article

Histone proteins determined in a human colon cancer by high-performance liquid chromatography and mass spectrometry.

Naldi M, Andrisano V, Fiori J, Calonghi N, Pagnotta E, Parolin C, Pieraccini G, Masotti L.

J Chromatogr A. 2006 Sep 29;1129(1):73-81. Epub 2006 Aug 2.PMID: 16887128 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo.

Graham C, Tucker C, Creech J, Favours E, Billups CA, Liu T, Fouladi M, Freeman BB 3rd, Stewart CF, Houghton PJ.

Clin Cancer Res. 2006 Jan 1;12(1):223-34.PMID: 16397046 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC.

Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D.

Clin Cancer Res. 2009 Apr 1;15(7):2488-96. Epub 2009 Mar 24.PMID: 19318486 [PubMed - indexed for MEDLINE]Related articles

Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells.

Liu S, Klisovic RB, Vukosavljevic T, Yu J, Paschka P, Huynh L, Pang J, Neviani P, Liu Z, Blum W, Chan KK, Perrotti D, Marcucci G.

J Pharmacol Exp Ther. 2007 Jun;321(3):953-60. Epub 2007 Mar 26.PMID: 17389244 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitation.

Lin T, Alam HB, Chen H, Britten-Webb J, Rhee P, Kirkpatrick J, Koustova E.

Surgery. 2006 Mar;139(3):365-76.PMID: 16546502 [PubMed - indexed for MEDLINE]Related articles

The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study.

de la Cruz-Hernández E, Pérez-Cárdenas E, Contreras-Paredes A, Cantú D, Mohar A, Lizano M, Dueñas-González A.

Virol J. 2007 Feb 26;4:18.PMID: 17324262 [PubMed - indexed for MEDLINE]Related articlesFree article

Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives.

Eikel D, Lampen A, Nau H.

Chem Res Toxicol. 2006 Feb;19(2):272-8.PMID: 16485903 [PubMed - indexed for MEDLINE]Related articles

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, La Thangue NB, Brown R.

Mol Cancer Ther. 2003 Aug;2(8):721-8.PMID: 12939461 [PubMed - indexed for MEDLINE]Related articlesFree article

Surrogate alcohols and their metabolites modify histone H3 acetylation: involvement of histone acetyl transferase and histone deacetylase.

Choudhury M, Shukla SD.

Alcohol Clin Exp Res. 2008 May;32(5):829-39. Epub 2008 Mar 11.PMID: 18336638 [PubMed - indexed for MEDLINE]Related articles

Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.

Nian H, Bisson WH, Dashwood WM, Pinto JT, Dashwood RH.

Carcinogenesis. 2009 Aug;30(8):1416-23. Epub 2009 Jun 15.PMID: 19528666 [PubMed - indexed for MEDLINE]Related articles

HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers.

Vulcano F, Ciccarelli C, Mattia G, Marampon F, Giampiero M, Milazzo L, Pascuccio M, Zani BM, Giampaolo A, Hassan HJ.

Exp Cell Res. 2006 May 15;312(9):1590-7.PMID: 16739251 [PubMed - indexed for MEDLINE]Related articles

Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC.

Li XN, Shu Q, Su JM, Perlaky L, Blaney SM, Lau CC.

Mol Cancer Ther. 2005 Dec;4(12):1912-22.PMID: 16373706 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.

Suzuki J, Chen YY, Scott GK, Devries S, Chin K, Benz CC, Waldman FM, Hwang ES.

Clin Cancer Res. 2009 May 1;15(9):3163-71. Epub 2009 Apr 21.PMID: 19383825 [PubMed - indexed for MEDLINE]Related articles

Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.

Dedes KJ, Dedes I, Imesch P, von Bueren AO, Fink D, Fedier A.

Anticancer Drugs. 2009 Jun;20(5):321-33.PMID: 19322073 [PubMed - indexed for MEDLINE]Related articles

Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells.

Rahim R, Strobl JS.

Anticancer Drugs. 2009 Sep;20(8):736-45.PMID: 19584707 [PubMed - indexed for MEDLINE]Related articles

Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial.

Atmaca A, Al-Batran SE, Maurer A, Neumann A, Heinzel T, Hentsch B, Schwarz SE, Hövelmann S, Göttlicher M, Knuth A, Jäger E.

Br J Cancer. 2007 Jul 16;97(2):177-82. Epub 2007 Jun 19.PMID: 17579623 [PubMed - indexed for MEDLINE]Related articlesFree article

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

Bradbury CA, Khanim FL, Hayden R, Bunce CM, White DA, Drayson MT, Craddock C, Turner BM.

Leukemia. 2005 Oct;19(10):1751-9.PMID: 16121216 [PubMed - indexed for MEDLINE]Related articles

Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A.

Kypreou KP, Sourlingas TG, Sekeri-Pataryas KE.

Exp Gerontol. 2004 Apr;39(4):469-79.PMID: 15050280 [PubMed - indexed for MEDLINE]Related articles

Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors.

de Bono JS, Kristeleit R, Tolcher A, Fong P, Pacey S, Karavasilis V, Mita M, Shaw H, Workman P, Kaye S, Rowinsky EK, Aherne W, Atadja P, Scott JW, Patnaik A.

Clin Cancer Res. 2008 Oct 15;14(20):6663-73.PMID: 18927309 [PubMed - indexed for MEDLINE]Related articlesFree article