PubMed

Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.

Stride A, Ellard S, Clark P, Shakespeare L, Salzmann M, Shepherd M, Hattersley AT.

Diabetes Care. 2005 Jul;28(7):1751-6.PMID: 15983330 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.

Pearson ER, Velho G, Clark P, Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Froguel P, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S101-7.PMID: 11272165 [PubMed - indexed for MEDLINE]Related articles

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT.

Diabetes Care. 2004 May;27(5):1102-7.PMID: 15111528 [PubMed - indexed for MEDLINE]Related articlesFree article

A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene.

Menzel R, Kaisaki PJ, Rjasanowski I, Heinke P, Kerner W, Menzel S.

Diabet Med. 1998 Oct;15(10):816-20.PMID: 9796880 [PubMed - indexed for MEDLINE]Related articles

Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

Sagen JV, Pearson ER, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad PR, Hattersley AT, Hansen T.

Diabet Med. 2005 Apr;22(4):406-9.PMID: 15787664 [PubMed - indexed for MEDLINE]Related articles

The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria.

Bingham C, Ellard S, Nicholls AJ, Pennock CA, Allen J, James AJ, Satchell SC, Salzmann MB, Hattersley AT.

Diabetes. 2001 Sep;50(9):2047-52.PMID: 11522670 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion and insulin sensitivity in diabetic and non-diabetic subjects with hepatic nuclear factor-1alpha (maturity-onset diabetes of the young-3) mutations.

Vaxillaire M, Pueyo ME, Clément K, Fiet J, Timsit J, Philippe J, Robert JJ, Tappy L, Froguel P, Velho G.

Eur J Endocrinol. 1999 Dec;141(6):609-18.PMID: 10601964 [PubMed - indexed for MEDLINE]Related articlesFree article

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.PMID: 11904435 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus.

Lauenborg J, Damm P, Ek J, Glümer C, Jørgensen T, Borch-Johnsen K, Vestergaard H, Hornnes P, Pedersen O, Hansen T.

Diabet Med. 2004 Dec;21(12):1310-5.PMID: 15569134 [PubMed - indexed for MEDLINE]Related articles

The genetic abnormality in the beta cell determines the response to an oral glucose load.

Stride A, Vaxillaire M, Tuomi T, Barbetti F, Njølstad PR, Hansen T, Costa A, Conget I, Pedersen O, Søvik O, Lorini R, Groop L, Froguel P, Hattersley AT.

Diabetologia. 2002 Mar;45(3):427-35.PMID: 11914749 [PubMed - indexed for MEDLINE]Related articles

Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effect.

Klupa T, Warram JH, Antonellis A, Pezzolesi M, Nam M, Malecki MT, Doria A, Rich SS, Krolewski AS.

Diabetes Care. 2002 Dec;25(12):2292-301.PMID: 12453976 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.

Stride A, Shepherd M, Frayling TM, Bulman MP, Ellard S, Hattersley AT.

Diabetes Care. 2002 Dec;25(12):2287-91.PMID: 12453975 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues.

Winzell MS, Pacini G, Wollheim CB, Ahrén B.

Diabetes. 2004 Dec;53 Suppl 3:S92-6.PMID: 15561929 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS.

J Clin Invest. 1998 May 15;101(10):2215-22.PMID: 9593777 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.

Hansen T, Eiberg H, Rouard M, Vaxillaire M, Møller AM, Rasmussen SK, Fridberg M, Urhammer SA, Holst JJ, Almind K, Echwald SM, Hansen L, Bell GI, Pedersen O.

Diabetes. 1997 Apr;46(4):726-30.PMID: 9075819 [PubMed - indexed for MEDLINE]Related articles

The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.

Urhammer SA, Møller AM, Nyholm B, Ekstrøm CT, Eiberg H, Clausen JO, Hansen T, Pedersen O, Schmitz O.

J Clin Endocrinol Metab. 1998 Nov;83(11):3992-5.PMID: 9814481 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes.

Doria A, Yang Y, Malecki M, Scotti S, Dreyfus J, O'Keeffe C, Orban T, Warram JH, Krolewski AS.

Diabetes Care. 1999 Feb;22(2):253-61.PMID: 10333942 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

Frayling TM, Evans JC, Bulman MP, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, Hattersley AT.

Diabetes. 2001 Feb;50 Suppl 1:S94-100.PMID: 11272211 [PubMed - indexed for MEDLINE]Related articles

Genetic cause of hyperglycaemia and response to treatment in diabetes.

Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT.

Lancet. 2003 Oct 18;362(9392):1275-81.PMID: 14575972 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion and insulin sensitivity in diabetic subgroups: studies in the prediabetic and diabetic state.

Tripathy D, Carlsson AL, Lehto M, Isomaa B, Tuomi T, Groop L.

Diabetologia. 2000 Dec;43(12):1476-83.PMID: 11151756 [PubMed - indexed for MEDLINE]Related articles