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    Results: 1 to 20 of 268

    1.

    Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.

    Hull RL, Shen ZP, Watts MR, Kodama K, Carr DB, Utzschneider KM, Zraika S, Wang F, Kahn SE.

    Diabetes. 2005 Jul;54(7):2235-44.PMID: 15983227 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.

    Hull RL, Zraika S, Udayasankar J, Kisilevsky R, Szarek WA, Wight TN, Kahn SE.

    Am J Physiol Cell Physiol. 2007 Nov;293(5):C1586-93. Epub 2007 Sep 5.PMID: 17804609 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

    Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

    Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

    Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.

    J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4.PMID: 16204373 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells.

    Verchere CB, D'Alessio DA, Prigeon RL, Hull RL, Kahn SE.

    Diabetes. 2000 Sep;49(9):1477-84.PMID: 10969831 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

    D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

    Diabetes. 1994 Dec;43(12):1457-61.PMID: 7958499 [PubMed - indexed for MEDLINE]Related articles

    8.

    Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.

    Hull RL, Watts MR, Kodama K, Shen ZP, Utzschneider KM, Carr DB, Vidal J, Kahn SE.

    Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E703-9. Epub 2005 May 17. Erratum in: Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E205. PMID: 15899941 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction.

    Couce M, Kane LA, O'Brien TD, Charlesworth J, Soeller W, McNeish J, Kreutter D, Roche P, Butler PC.

    Diabetes. 1996 Aug;45(8):1094-101.PMID: 8690157 [PubMed - indexed for MEDLINE]Related articles

    10.

    Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

    Butler AE, Janson J, Soeller WC, Butler PC.

    Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

    de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

    Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Glucose- and time-dependence of islet amyloid formation in vitro.

    Zraika S, Hull RL, Udayasankar J, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

    Biochem Biophys Res Commun. 2007 Mar 2;354(1):234-9. Epub 2007 Jan 2.PMID: 17222388 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.

    Udayasankar J, Kodama K, Hull RL, Zraika S, Aston-Mourney K, Subramanian SL, Tong J, Faulenbach MV, Vidal J, Kahn SE.

    Diabetologia. 2009 Jan;52(1):145-53. Epub 2008 Nov 11.PMID: 19002432 [PubMed - indexed for MEDLINE]Related articles

    14.

    Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets.

    MacArthur DL, de Koning EJ, Verbeek JS, Morris JF, Clark A.

    Diabetologia. 1999 Oct;42(10):1219-27.PMID: 10525663 [PubMed - indexed for MEDLINE]Related articles

    15.

    DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.

    Ahrén B, Winzell MS, Wierup N, Sundler F, Burkey B, Hughes TE.

    Regul Pept. 2007 Oct 4;143(1-3):97-103. Epub 2007 Apr 11.PMID: 17482289 [PubMed - indexed for MEDLINE]Related articles

    16.

    Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans.

    de Koning EJ, Höppener JW, Verbeek JS, Oosterwijk C, van Hulst KL, Baker CA, Lips CJ, Morris JF, Clark A.

    Diabetes. 1994 May;43(5):640-4.PMID: 8168639 [PubMed - indexed for MEDLINE]Related articles

    17.

    Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

    Kahn SE, Andrikopoulos S, Verchere CB, Wang F, Hull RL, Vidal J.

    Diabetologia. 2000 Oct;43(10):1309-12.PMID: 11079750 [PubMed - indexed for MEDLINE]Related articles

    18.

    Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

    Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

    Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

    19.

    The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

    Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

    Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.PMID: 12637985 [PubMed - indexed for MEDLINE]Related articles

    20.

    Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

    Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC.

    Diabetes. 2004 Jun;53(6):1509-16.PMID: 15161755 [PubMed - indexed for MEDLINE]Related articlesFree article

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