PubMed

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.

Jörns A, Günther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S.

Diabetes. 2005 Jul;54(7):2041-52.PMID: 15983205 [PubMed - indexed for MEDLINE]Related articlesFree article

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.

Arndt T, Wedekind D, Weiss H, Tiedge M, Lenzen S, Hedrich HJ, Jörns A.

Diabetologia. 2009 Jul;52(7):1381-90. Epub 2009 Apr 15.PMID: 19367386 [PubMed - indexed for MEDLINE]Related articles

Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide.

Reddy S, Young M, Ginn S.

Histochem J. 2001 Jun;33(6):317-27.PMID: 11758808 [PubMed - indexed for MEDLINE]Related articles

Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM.

Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, Sorensen O, Power RF.

Diabetes. 1996 Jun;45(6):749-54.PMID: 8635648 [PubMed - indexed for MEDLINE]Related articles

The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus.

Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jörns A, Klöppel G, Wedekind D, Prokop CM, Hedrich HJ.

Diabetologia. 2001 Sep;44(9):1189-96.PMID: 11596676 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation.

Montolio M, Biarnés M, Téllez N, Escoriza J, Soler J, Montanya E.

J Endocrinol. 2007 Jan;192(1):169-77.PMID: 17210754 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

J Immunol. 2004 May 1;172(9):5714-21.PMID: 15100317 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells.

Yoon JW, Jun HS, Santamaria P.

Autoimmunity. 1998;27(2):109-22. Review.PMID: 9583742 [PubMed - indexed for MEDLINE]Related articles

Inducible nitric oxide synthase in pancreatic islets of the non-obese diabetic mouse: a light and confocal microscopical study of its ontogeny, co-localization and up-regulation following cytokine administration.

Reddy S, Kaill S, Poole CA, Ross J.

Histochem J. 1997 Jan;29(1):53-64.PMID: 9088945 [PubMed - indexed for MEDLINE]Related articles

Syngeneic islet transplantation in prediabetic BB-DP rats--a synchronized model for studying beta-cell destruction during the development of IDDM.

Christensen UB, Sparre T, Cooke A, Andersen HU, Mandrup-Poulsen T, Nerup J.

Autoimmunity. 1998;28(2):91-107.PMID: 9771979 [PubMed - indexed for MEDLINE]Related articles

In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.

Pakala SV, Chivetta M, Kelly CB, Katz JD.

J Exp Med. 1999 Apr 5;189(7):1053-62.PMID: 10190896 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus.

Yoon JW, Jun HS.

Ann N Y Acad Sci. 2001 Apr;928:200-11. Review.PMID: 11795511 [PubMed - indexed for MEDLINE]Related articles

Fas and Fas ligand immunolocalization in pancreatic islets of NOD mice during spontaneous and cyclophosphamide-accelerated diabetes.

Redd S, Ginn S, Ross JM.

Histochem J. 2002 Jan-Feb;34(1-2):1-12.PMID: 12365794 [PubMed - indexed for MEDLINE]Related articles

IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction.

Wachlin G, Augstein P, Schröder D, Kuttler B, Klöting I, Heinke P, Schmidt S.

J Autoimmun. 2003 Jun;20(4):303-12.PMID: 12791316 [PubMed - indexed for MEDLINE]Related articles

Both CD4(+)and CD8(+)T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats.

El-Sheikh A, Suarez-Pinzon WL, Power RF, Rabinovitch A.

J Autoimmun. 1999 Mar;12(2):109-19.PMID: 10047431 [PubMed - indexed for MEDLINE]Related articles

Immunohistochemical study of caspase-3-expressing cells within the pancreas of non-obese diabetic mice during cyclophosphamide-accelerated diabetes.

Reddy S, Bradley J, Ginn S, Pathipati P, Ross JM.

Histochem Cell Biol. 2003 Jun;119(6):451-61. Epub 2003 Jun 11.PMID: 12802593 [PubMed - indexed for MEDLINE]Related articles

Preservation of beta-cell function during immune-mediated, B7-1-dependent alpha-cell destruction.

Skak K, Haase C, Michelsen BK.

Eur J Immunol. 2005 Sep;35(9):2583-90.PMID: 16078275 [PubMed - indexed for MEDLINE]Related articles

IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.

Thomas HE, Irawaty W, Darwiche R, Brodnicki TC, Santamaria P, Allison J, Kay TW.

Diabetes. 2004 Jan;53(1):113-21.PMID: 14693705 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes.

Augstein P, Elefanty AG, Allison J, Harrison LC.

Diabetologia. 1998 Nov;41(11):1381-8.PMID: 9833948 [PubMed - indexed for MEDLINE]Related articles