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    Results: 1 to 20 of 332

    1.

    Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.

    Fukui K, Wada T, Kagawa S, Nagira K, Ikubo M, Ishihara H, Kobayashi M, Sasaoka T.

    Diabetes. 2005 Jul;54(7):1958-67.PMID: 15983195 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.

    Kagawa S, Soeda Y, Ishihara H, Oya T, Sasahara M, Yaguchi S, Oshita R, Wada T, Tsuneki H, Sasaoka T.

    Endocrinology. 2008 Feb;149(2):642-50. Epub 2007 Nov 26.PMID: 18039790 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.

    Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.

    Mol Cell Biol. 2001 Mar;21(5):1633-46.PMID: 11238900 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.

    Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N.

    Diabetes. 2007 Sep;56(9):2235-41. Epub 2007 Jun 27.PMID: 17596404 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

    Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

    J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.PMID: 14985368 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.

    Ishihara H, Sasaoka T, Ishiki M, Wada T, Hori H, Kagawa S, Kobayashi M.

    Mol Endocrinol. 2002 Oct;16(10):2371-81.PMID: 12351701 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.

    Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M.

    Diabetologia. 2001 Oct;44(10):1258-67.PMID: 11692174 [PubMed - indexed for MEDLINE]Related articles

    8.

    Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.

    Sasaoka T, Kikuchi K, Wada T, Sato A, Hori H, Murakami S, Fukui K, Ishihara H, Aota R, Kimura I, Kobayashi M.

    Endocrinology. 2003 Sep;144(9):4204-14.PMID: 12933696 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice.

    Qiao L, MacLean PS, You H, Schaack J, Shao J.

    Endocrinology. 2006 Jun;147(6):3060-9. Epub 2006 Mar 16.PMID: 16543372 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.

    Bécard D, Hainault I, Azzout-Marniche D, Bertry-Coussot L, Ferré P, Foufelle F.

    Diabetes. 2001 Nov;50(11):2425-30.PMID: 11679417 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.

    Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M.

    J Biol Chem. 2004 Apr 9;279(15):14835-43. Epub 2004 Jan 26.PMID: 14744864 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

    Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ.

    Endocrinology. 2004 Feb;145(2):650-8. Epub 2003 Nov 14.PMID: 14617577 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.

    Hori H, Sasaoka T, Ishihara H, Wada T, Murakami S, Ishiki M, Kobayashi M.

    Diabetes. 2002 Aug;51(8):2387-94.PMID: 12145149 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.

    Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T.

    Diabetes. 2003 Dec;52(12):2905-13.PMID: 14633850 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.

    Ishihara H, Sasaoka T, Hori H, Wada T, Hirai H, Haruta T, Langlois WJ, Kobayashi M.

    Biochem Biophys Res Commun. 1999 Jun 24;260(1):265-72.PMID: 10381377 [PubMed - indexed for MEDLINE]Related articles

    16.

    Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.

    Murakami S, Sasaoka T, Wada T, Fukui K, Nagira K, Ishihara H, Usui I, Kobayashi M.

    Endocrinology. 2004 Jul;145(7):3215-23. Epub 2004 Mar 24.PMID: 15044364 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression.

    Scott DK, Collier JJ, Doan TT, Bunnell AS, Daniels MC, Eckert DT, O'Doherty RM.

    Mol Cell Biochem. 2003 Dec;254(1-2):327-37.PMID: 14674713 [PubMed - indexed for MEDLINE]Related articles

    18.

    Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.

    Ikubo M, Wada T, Fukui K, Ishiki M, Ishihara H, Asano T, Tsuneki H, Sasaoka T.

    Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E157-64. Epub 2008 Nov 11.PMID: 19001549 [PubMed - indexed for MEDLINE]Related articles

    19.

    Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome.

    Buettner R, Ottinger I, Gerhardt-Salbert C, Wrede CE, Schölmerich J, Bollheimer LC.

    Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1871-8. Epub 2007 Feb 27.PMID: 17327370 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.

    Sasaoka T, Wada T, Tsuneki H.

    Pharmacol Ther. 2006 Dec;112(3):799-809. Epub 2006 Jul 13. Review.PMID: 16842857 [PubMed - indexed for MEDLINE]Related articles

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