PubMed

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.

't Hart LM, Hansen T, Rietveld I, Dekker JM, Nijpels G, Janssen GM, Arp PA, Uitterlinden AG, Jørgensen T, Borch-Johnsen K, Pols HA, Pedersen O, van Duijn CM, Heine RJ, Maassen JA.

Diabetes. 2005 Jun;54(6):1892-5.PMID: 15919814 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia.

Munakata K, Iwamoto K, Bundo M, Kato T.

Biol Psychiatry. 2005 Mar 1;57(5):525-32.PMID: 15737668 [PubMed - indexed for MEDLINE]Related articles

Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase.

Sohm B, Sissler M, Park H, King MP, Florentz C.

J Mol Biol. 2004 May 21;339(1):17-29.PMID: 15123417 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial gene variation in type 2 diabetes mellitus: detection of a novel mutation associated with maternally inherited diabetes in a Chinese family.

Ma L, Wang H, Chen J, Jin W, Liu L, Ban B, Shen J, Hua Z, Chai J.

Chin Med J (Engl). 2000 Feb;113(2):111-6.PMID: 11775531 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence and clinical characteristics of mitochondrial tRNA leu(UUR) mt 3243 A-->G and ND-1 gene mt 3316 G-->A mutations in Chinese patients with type 2 diabetes.

Ji L, Hou X, Han X.

Chin Med J (Engl). 2001 Nov;114(11):1205-7.PMID: 11729521 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.

Furukawa Y, Shimada T, Furuta H, Matsuno S, Kusuyama A, Doi A, Nishi M, Sasaki H, Sanke T, Nanjo K.

J Clin Endocrinol Metab. 2008 Jan;93(1):310-4. Epub 2007 Oct 30.PMID: 17971426 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene.

Park H, Davidson E, King MP.

RNA. 2008 Nov;14(11):2407-16. Epub 2008 Sep 16.PMID: 18796578 [PubMed - indexed for MEDLINE]Related articlesFree article

Search for mitochondrial A3243G tRNA(Leu) mutation in Polish patients with type 2 diabetes mellitus.

Małecki M, Klupa T, Wanic K, Frey J, Cyganek K, Sieradzki J.

Med Sci Monit. 2001 Mar-Apr;7(2):246-50.PMID: 11257730 [PubMed - indexed for MEDLINE]Related articles

[Study on mitochondrial DNA gene tRNA(Leu(UUR)) A3243G mutation in type 2 diabetes mellitus]

Zhang XY, Zhang SL, Ke BS, Jiang ZS, Sun R.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Apr;21(2):168-70. Chinese. PMID: 15079803 [PubMed - indexed for MEDLINE]Related articles

The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation.

Park H, Davidson E, King MP.

Biochemistry. 2003 Feb 4;42(4):958-64.PMID: 12549915 [PubMed - indexed for MEDLINE]Related articles

Presence of mitochondrial tRNA(Leu(UUR)) A to G 3243 mutation in DNA extracted from serum and plasma of patients with type 2 diabetes mellitus.

Zhong S, Ng MC, Lo YM, Chan JC, Johnson PJ.

J Clin Pathol. 2000 Jun;53(6):466-9.PMID: 10911806 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel mitochondrial 16S rRNA mutation, 3200T-->C, associated with adult-onset type 2 diabetes.

Yang T, Lam CW, Tsang MW, Tong SF, Kam GY, Chan LY, Poon PM, Wu X, Pang CP.

Chin Med J (Engl). 2002 May;115(5):753-8.PMID: 12133550 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM, Dekker JM.

Eur J Hum Genet. 2009 Aug;17(8):1056-62. Epub 2009 Feb 11.PMID: 19209188 [PubMed - indexed for MEDLINE]Related articles

Association between peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene polymorphisms and type 2 diabetes in southern Chinese population: role of altered interaction with myocyte enhancer factor 2C.

Zhang SL, Lu WS, Yan L, Wu MC, Xu MT, Chen LH, Cheng H.

Chin Med J (Engl). 2007 Nov 5;120(21):1878-85.PMID: 18067759 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations.

Nitz I, Fisher E, Grallert H, Li Y, Gieger C, Rubin D, Boeing H, Spranger J, Lindner I, Schreiber S, Rathmann W, Gohlke H, Döring A, Wichmann HE, Schrezenmeir J, Döring F, Illig T.

J Clin Endocrinol Metab. 2007 Aug;92(8):3183-8. Epub 2007 Jun 12.PMID: 17566096 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis.

Das SK, Sharma NK, Chu WS, Wang H, Elbein SC.

BMC Med Genet. 2008 Mar 17;9:16.PMID: 18366646 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic association analysis of LARS2 with type 2 diabetes.

Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation.

Fisher E, Nitz I, Lindner I, Rubin D, Boeing H, Möhlig M, Hampe J, Schreiber S, Schrezenmeir J, Döring F.

Mol Nutr Food Res. 2007 Feb;51(2):185-91.PMID: 17266179 [PubMed - indexed for MEDLINE]Related articles

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI.

Diabetes. 2003 May;52(5):1300-5.PMID: 12716770 [PubMed - indexed for MEDLINE]Related articlesFree article

Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.

Lin WH, Chuang LM, Chen CH, Yeh JI, Hsieh PS, Cheng CH, Chen YT.

Diabetologia. 2006 Jun;49(6):1214-21. Epub 2006 Apr 4.PMID: 16586067 [PubMed - indexed for MEDLINE]Related articles