PubMed

Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy.

Cai L, Wang J, Li Y, Sun X, Wang L, Zhou Z, Kang YJ.

Diabetes. 2005 Jun;54(6):1829-37.PMID: 15919806 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.

Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ.

J Am Coll Cardiol. 2006 Oct 17;48(8):1688-97. Epub 2006 Sep 27.PMID: 17045908 [PubMed - indexed for MEDLINE]Related articles

Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment.

Shuai Y, Guo JB, Peng SQ, Zhang LS, Guo J, Han G, Dong YS.

Toxicol Lett. 2007 Apr 5;170(1):66-74. Epub 2007 Feb 21.PMID: 17382496 [PubMed - indexed for MEDLINE]Related articles

Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.

Zhou G, Li X, Hein DW, Xiang X, Marshall JP, Prabhu SD, Cai L.

J Am Coll Cardiol. 2008 Aug 19;52(8):655-66.PMID: 18702970 [PubMed - indexed for MEDLINE]Related articles

Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.

Wang Y, Feng W, Xue W, Tan Y, Hein DW, Li XK, Cai L.

Diabetes. 2009 Jun;58(6):1391-402. Epub 2009 Mar 26.PMID: 19324938 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury.

Song Y, Wang J, Li Y, Du Y, Arteel GE, Saari JT, Kang YJ, Cai L.

Am J Pathol. 2005 Jul;167(1):17-26.PMID: 15972948 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation.

Wang J, Song Y, Elsherif L, Song Z, Zhou G, Prabhu SD, Saari JT, Cai L.

Circulation. 2006 Jan 31;113(4):544-54. Epub 2006 Jan 23.PMID: 16432057 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.

Wold LE, Ceylan-Isik AF, Fang CX, Yang X, Li SY, Sreejayan N, Privratsky JR, Ren J.

Free Radic Biol Med. 2006 Apr 15;40(8):1419-29. Epub 2006 Jan 6.PMID: 16631532 [PubMed - indexed for MEDLINE]Related articles

Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications.

Cai L.

Curr Med Chem. 2007;14(20):2193-203. Review.PMID: 17691957 [PubMed - indexed for MEDLINE]Related articles

Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy.

Cai L.

Free Radic Biol Med. 2006 Sep 15;41(6):851-61. Epub 2006 Jun 15. Review.PMID: 16934665 [PubMed - indexed for MEDLINE]Related articles

Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions.

Feng W, Wang Y, Cai L, Kang YJ.

Biochem Biophys Res Commun. 2007 Aug 17;360(1):286-9. Epub 2007 Jun 19.PMID: 17586470 [PubMed - indexed for MEDLINE]Related articles

Overexpression of metallothionein reduces diabetic cardiomyopathy.

Liang Q, Carlson EC, Donthi RV, Kralik PM, Shen X, Epstein PN.

Diabetes. 2002 Jan;51(1):174-81.PMID: 11756338 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production.

Ye G, Metreveli NS, Ren J, Epstein PN.

Diabetes. 2003 Mar;52(3):777-83.PMID: 12606520 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.

Pacher P, Obrosova IG, Mabley JG, Szabó C.

Curr Med Chem. 2005;12(3):267-75. Review.PMID: 15723618 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice.

Wang Y, Ebermann L, Sterner-Kock A, Wika S, Schultheiss HP, Dörner A, Walther T.

Exp Physiol. 2009 Feb;94(2):220-7. Epub 2008 Oct 22.PMID: 18945756 [PubMed - indexed for MEDLINE]Related articles

Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection.

Xu J, Wang G, Wang Y, Liu Q, Xu W, Tan Y, Cai L.

J Cell Mol Med. 2009 Aug;13(8A):1499-512. Epub 2009 Jul 6.PMID: 19583814 [PubMed - in process]Related articles

Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity.

Sun X, Kang YJ.

Exp Biol Med (Maywood). 2002 Sep;227(8):652-7.PMID: 12192109 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress.

Yang X, Doser TA, Fang CX, Nunn JM, Janardhanan R, Zhu M, Sreejayan N, Quinn MT, Ren J.

FASEB J. 2006 May;20(7):1024-6. Epub 2006 Apr 3.PMID: 16585059 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart.

Sun X, Zhou Z, Kang YJ.

Cancer Res. 2001 Apr 15;61(8):3382-7.PMID: 11309296 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

Kang YJ, Chen Y, Yu A, Voss-McCowan M, Epstein PN.

J Clin Invest. 1997 Sep 15;100(6):1501-6.PMID: 9294117 [PubMed - indexed for MEDLINE]Related articlesFree article