PubMed

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.

Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A.

Diabetes. 2005 Jun;54(6):1706-16.PMID: 15919792 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression.

Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, Reddy JK.

J Biol Chem. 2003 Jan 3;278(1):498-505. Epub 2002 Oct 24.PMID: 12401792 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of increased PPARgamma activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglitazone treatment.

Takasawa K, Kubota N, Terauchi Y, Kadowaki T.

Endocr J. 2008 Aug;55(4):767-76. Epub 2008 May 28.PMID: 18506083 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

Vidal-Puig AJ, Considine RV, Jimenez-Liñan M, Werman A, Pories WJ, Caro JF, Flier JS.

J Clin Invest. 1997 May 15;99(10):2416-22.PMID: 9153284 [PubMed - indexed for MEDLINE]Related articlesFree article

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels.

Lindgren EM, Nielsen R, Petrovic N, Jacobsson A, Mandrup S, Cannon B, Nedergaard J.

Biochem J. 2004 Sep 1;382(Pt 2):597-606.PMID: 15193150 [PubMed - indexed for MEDLINE]Related articlesFree article

The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro.

Jitrapakdee S, Slawik M, Medina-Gomez G, Campbell M, Wallace JC, Sethi JK, O'rahilly S, Vidal-Puig AJ.

J Biol Chem. 2005 Jul 22;280(29):27466-76. Epub 2005 May 25.PMID: 15917242 [PubMed - indexed for MEDLINE]Related articlesFree article

FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity.

Armoni M, Harel C, Karni S, Chen H, Bar-Yoseph F, Ver MR, Quon MJ, Karnieli E.

J Biol Chem. 2006 Jul 21;281(29):19881-91. Epub 2006 May 2.PMID: 16670091 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity.

Zhang J, Fu M, Cui T, Xiong C, Xu K, Zhong W, Xiao Y, Floyd D, Liang J, Li E, Song Q, Chen YE.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10703-8. Epub 2004 Jul 12.PMID: 15249658 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12. Epub 2005 Apr 15.PMID: 15833818 [PubMed - indexed for MEDLINE]Related articlesFree article

The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes.

Arimura N, Horiba T, Imagawa M, Shimizu M, Sato R.

J Biol Chem. 2004 Mar 12;279(11):10070-6. Epub 2004 Jan 2.PMID: 14704148 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR-gamma2 expression in response to cafeteria diet: gender- and depot-specific effects.

Rodríguez E, Ribot J, Rodríguez AM, Palou A.

Obes Res. 2004 Sep;12(9):1455-63.PMID: 15483210 [PubMed - indexed for MEDLINE]Related articles

Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms.

Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM.

J Biol Chem. 2002 Nov 1;277(44):41925-30. Epub 2002 Aug 27.PMID: 12200443 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver.

Yu S, Viswakarma N, Batra SK, Sambasiva Rao M, Reddy JK.

Biochimie. 2004 Nov;86(11):743-61.PMID: 15589683 [PubMed - indexed for MEDLINE]Related articles

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.

Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A.

Nature. 2007 Jun 28;447(7148):1116-20. Epub 2007 May 21.PMID: 17515919 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1).

Medina-Gomez G, Gray S, Vidal-Puig A.

Public Health Nutr. 2007 Oct;10(10A):1132-7. Review.PMID: 17903321 [PubMed - indexed for MEDLINE]Related articles

Differential effects of adiposity on peroxisomal proliferator-activated receptor gamma1 and gamma2 messenger ribonucleic acid expression in human adipocytes.

Sewter C, Blows F, Considine R, Vidal-Puig A, O'Rahilly S.

J Clin Endocrinol Metab. 2002 Sep;87(9):4203-7.PMID: 12213872 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.

Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A.

Diabetes. 2006 Oct;55(10):2669-77.PMID: 17003330 [PubMed - indexed for MEDLINE]Related articlesFree article

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.

Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky JM.

Diabetes. 2009 Jun;58(6):1275-82. Epub 2009 Mar 16.PMID: 19289458 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1736-45. Epub 2007 Sep 11.PMID: 17848638 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.

Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy MF, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J.

Cell Metab. 2009 Jan 7;9(1):88-98.PMID: 19117549 [PubMed - indexed for MEDLINE]Related articles