PubMed

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice.

Rao P, Roccisana J, Takane KK, Bottino R, Zhao A, Trucco M, García-Ocaña A.

Diabetes. 2005 Jun;54(6):1664-75.PMID: 15919787 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.

J Biol Chem. 2003 Jan 3;278(1):343-51. Epub 2002 Oct 25.PMID: 12403787 [PubMed - indexed for MEDLINE]Related articlesFree article

Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets.

Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, Eckhoff DE.

Transplantation. 2002 Oct 27;74(8):1063-9.PMID: 12438947 [PubMed - indexed for MEDLINE]Related articles

Insulin gene transfer enhances the function of human islet grafts.

Deng S, Vatamaniuk M, Lian MM, Doliba N, Wang J, Bell E, Wolf B, Raper S, Matschinsky FM, Markmann JF.

Diabetologia. 2003 Mar;46(3):386-93. Epub 2003 Mar 7.PMID: 12687337 [PubMed - indexed for MEDLINE]Related articles

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation.

Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori RL.

Diabetologia. 2008 Feb;51(2):298-308. Epub 2007 Dec 8.PMID: 18066521 [PubMed - indexed for MEDLINE]Related articles

Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function.

Narang AS, Sabek O, Gaber AO, Mahato RI.

Pharm Res. 2006 Sep;23(9):1970-82. Epub 2006 Aug 12.PMID: 16906455 [PubMed - indexed for MEDLINE]Related articles

Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice.

Smith DK, Korbutt GS, Suarez-Pinzon WL, Kao D, Rajotte RV, Elliott JF.

Transplantation. 1997 Oct 15;64(7):1040-9.PMID: 9381527 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets.

Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF.

Diabetes. 2008 Oct;57(10):2745-54.PMID: 18820214 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.

Lopez-Talavera JC, Garcia-Ocaña A, Sipula I, Takane KK, Cozar-Castellano I, Stewart AF.

Endocrinology. 2004 Feb;145(2):467-74. Epub 2003 Oct 9.PMID: 14551233 [PubMed - indexed for MEDLINE]Related articlesFree article

Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation.

Panakanti R, Mahato RI.

Pharm Res. 2009 Mar;26(3):587-96. Epub 2008 Nov 12.PMID: 19002565 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice.

Dai C, Li Y, Yang J, Liu Y.

J Biol Chem. 2003 Jul 18;278(29):27080-7. Epub 2003 May 12.PMID: 12746445 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (PKB)/Akt.

Fiaschi-Taesch N, Stewart AF, Garcia-Ocaña A.

Cell Biochem Biophys. 2007;48(2-3):191-9. Review.PMID: 17709889 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo.

Päth G, Opel A, Gehlen M, Rothhammer V, Niu X, Limbert C, Romfeld L, Hügl S, Knoll A, Brendel MD, Bretzel RG, Seufert J.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1168-76. Epub 2006 Jul 5.PMID: 16822955 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice.

Montaña E, Bonner-Weir S, Weir GC.

J Clin Invest. 1993 Mar;91(3):780-7.PMID: 8450059 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice.

Suarez-Pinzon WL, Lakey JR, Rabinovitch A.

Cell Transplant. 2008;17(6):631-40.PMID: 18819251 [PubMed - indexed for MEDLINE]Related articles

Elevated vascular endothelial growth factor production in islets improves islet graft vascularization.

Zhang N, Richter A, Suriawinata J, Harbaran S, Altomonte J, Cong L, Zhang H, Song K, Meseck M, Bromberg J, Dong H.

Diabetes. 2004 Apr;53(4):963-70.PMID: 15047611 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene.

Contreras JL, Bilbao G, Smyth CA, Jiang XL, Eckhoff DE, Jenkins SM, Thomas FT, Curiel DT, Thomas JM.

Transplantation. 2001 Apr 27;71(8):1015-23.PMID: 11374395 [PubMed - indexed for MEDLINE]Related articles

The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts.

Plesner A, Liston P, Tan R, Korneluk RG, Verchere CB.

Diabetes. 2005 Sep;54(9):2533-40.PMID: 16123340 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets.

Bilbao G, Contreras JL, Dmitriev I, Smyth CA, Jenkins S, Eckhoff D, Thomas F, Thomas J, Curiel DT.

Am J Transplant. 2002 Mar;2(3):237-43.PMID: 12096786 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte growth factor gene therapy for islet transplantation.

Rao P, Cozar-Castellano I, Roccisana J, Vasavada RC, Garcia-Ocaña A.

Expert Opin Biol Ther. 2004 Apr;4(4):507-18. Review.PMID: 15102600 [PubMed - indexed for MEDLINE]Related articles