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    Results: 1 to 20 of 115

    1.

    Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes.

    Li L, Shi Y, Wang X, Shi W, Jiang C.

    Diabetes. 2005 May;54(5):1592-7.PMID: 15855351 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

    Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA.

    Diabetes. 2008 Jun;57(6):1595-604. Epub 2008 Mar 17.PMID: 18346985 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

    Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.

    Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8.PMID: 19587354 [PubMed - indexed for MEDLINE]Related articles

    4.

    The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

    Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

    Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

    Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

    Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.

    Schwanstecher C, Schwanstecher M.

    Diabetes. 2002 Dec;51 Suppl 3:S358-62. Review.PMID: 12475775 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    The E23K variant in the Kir6.2 subunit of the ATP-sensitive K+ channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes.

    Ezenwaka C, Kalloo R, Uhlig M, Schwenk R, Eckel J.

    J Endocrinol. 2005 Jun;185(3):439-44.PMID: 15930170 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study.

    Doi Y, Kubo M, Ninomiya T, Yonemoto K, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    Diabetes. 2007 Nov;56(11):2829-33.PMID: 17965318 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

    Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

    Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, Permutt MA.

    Diabetologia. 2003 Jan;46(1):136-7. No abstract available. PMID: 12643262 [PubMed - indexed for MEDLINE]Related articles

    11.

    Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

    Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

    Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Elimination of allosteric modulation of myocardial KATP channels by ATP and protons in two Kir6.2 polymorphisms found in sudden cardiac death.

    Cui N, Li L, Wang X, Shi Y, Shi W, Jiang C.

    Physiol Genomics. 2006 Mar 13;25(1):105-15. Epub 2006 Jan 10.PMID: 16403845 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.

    Schwanstecher C, Meyer U, Schwanstecher M.

    Diabetes. 2002 Mar;51(3):875-9.PMID: 11872696 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.

    Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P.

    Diabetologia. 1998 Dec;41(12):1511-5.PMID: 9867219 [PubMed - indexed for MEDLINE]Related articles

    15.

    Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes.

    Riedel MJ, Steckley DC, Light PE.

    Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23. Review.PMID: 15565284 [PubMed - indexed for MEDLINE]Related articles

    16.

    Kir6.2 mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+ channels: implications in disease mechanism and sulfonylurea therapy.

    Lin CW, Lin YW, Yan FF, Casey J, Kochhar M, Pratt EB, Shyng SL.

    Diabetes. 2006 Jun;55(6):1738-46.PMID: 16731837 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

    Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J.

    J Pharmacol Exp Ther. 2007 Aug;322(2):871-8. Epub 2007 May 23.PMID: 17522344 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates.

    Schwanstecher C, Neugebauer B, Schulz M, Schwanstecher M.

    Diabetes. 2002 Dec;51 Suppl 3:S363-7.PMID: 12475776 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    The effects of E23K polymorphism in Kir6.2 subunit on insulin sensitivity in skeletal muscle cells by long-chain fatty acyl CoA.

    Wan J, Jiang X, Bai J, Shen D, Wang T.

    Biochem Biophys Res Commun. 2009 Apr 17;381(4):496-501. Epub 2009 Feb 20.PMID: 19233137 [PubMed - indexed for MEDLINE]Related articles

    20.

    Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

    Riedel MJ, Boora P, Steckley D, de Vries G, Light PE.

    Diabetes. 2003 Oct;52(10):2630-5.PMID: 14514649 [PubMed - indexed for MEDLINE]Related articlesFree article

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