PubMed

The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.

Blankenhorn EP, Rodemich L, Martin-Fernandez C, Leif J, Greiner DL, Mordes JP.

Diabetes. 2005 Apr;54(4):1233-7.PMID: 15793267 [PubMed - indexed for MEDLINE]Related articlesFree article

The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.

Mordes JP, Leif J, Novak S, DeScipio C, Greiner DL, Blankenhorn EP.

Diabetes. 2002 Nov;51(11):3254-62.PMID: 12401717 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

Martin AM, Maxson MN, Leif J, Mordes JP, Greiner DL, Blankenhorn EP.

Diabetes. 1999 Nov;48(11):2138-44.PMID: 10535446 [PubMed - indexed for MEDLINE]Related articlesFree article

Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat.

Ellerman KE, Richards CA, Guberski DL, Shek WR, Like AA.

Diabetes. 1996 May;45(5):557-62.PMID: 8621003 [PubMed - indexed for MEDLINE]Related articles

Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.

Zipris D, Hillebrands JL, Welsh RM, Rozing J, Xie JX, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2003 Apr 1;170(7):3592-602.PMID: 12646622 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.

Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2005 Jan 1;174(1):131-42.PMID: 15611235 [PubMed - indexed for MEDLINE]Related articlesFree article

Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.

Blankenhorn EP, Descipio C, Rodemich L, Cort L, Leif JH, Greiner DL, Mordes JP.

Ann N Y Acad Sci. 2007 Apr;1103:128-31. Epub 2007 Mar 21.PMID: 17376830 [PubMed - indexed for MEDLINE]Related articles

PolyI:C induction of diabetes is controlled by Iddm4 in rats with a full regulatory T cell pool.

Hornum L, Lundsgaard D, Markholst H.

Ann N Y Acad Sci. 2007 Sep;1110:65-72.PMID: 17911421 [PubMed - indexed for MEDLINE]Related articles

Cellular and molecular mechanism for Kilham rat virus-induced autoimmune diabetes in DR-BB rats.

Chung YH, Jun HS, Son M, Bao M, Bae HY, Kang Y, Yoon JW.

J Immunol. 2000 Sep 1;165(5):2866-76.PMID: 10946320 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

Martin AM, Blankenhorn EP, Maxson MN, Zhao M, Leif J, Mordes JP, Greiner DL.

Diabetes. 1999 Jan;48(1):50-8.PMID: 9892222 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.

Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2007 Jan 15;178(2):693-701.PMID: 17202329 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat models of type 1 diabetes: genetics, environment, and autoimmunity.

Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL.

ILAR J. 2004;45(3):278-91. Review.PMID: 15229375 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens.

Thomas VA, Woda BA, Handler ES, Greiner DL, Mordes JP, Rossini AA.

Diabetes. 1991 Feb;40(2):255-8.PMID: 1703973 [PubMed - indexed for MEDLINE]Related articles

Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.

Mordes JP, Cort L, Norowski E, Leif J, Fuller JM, Lernmark A, Greiner DL, Blankenhorn EP.

Mamm Genome. 2009 Mar;20(3):162-9. Epub 2009 Feb 10.PMID: 19205800 [PubMed - indexed for MEDLINE]Related articles

Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats.

Chung YH, Jun HS, Kang Y, Hirasawa K, Lee BR, Van Rooijen N, Yoon JW.

J Immunol. 1997 Jul 1;159(1):466-71.PMID: 9200487 [PubMed - indexed for MEDLINE]Related articles

VIRUS-INDUCED AUTOIMMUNE DIABETES IN THE LEW.1WR1 RAT REQUIRES Iddm14 AND A GENETIC LOCUS PROXIMAL TO THE MAJOR HISTOCOMPATIBILITY COMPLEX.

Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP.

Diabetes. 2009 Aug 31. [Epub ahead of print]PMID: 19720792 [PubMed - as supplied by publisher]Related articles

Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats.

Ellerman KE, Like AA.

Diabetologia. 2000 Jul;43(7):890-8.PMID: 10952462 [PubMed - indexed for MEDLINE]Related articles

Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.

Hornum L, DeScipio C, Markholst H, Troutman SA, Novak S, Leif J, Greiner D, Mordes JP, Blankenhorn EP.

Mamm Genome. 2004 Jan;15(1):53-61.PMID: 14727142 [PubMed - indexed for MEDLINE]Related articles

Innate immune pathways in virus-induced autoimmune diabetes.

Nair A, Wolter TR, Meyers AJ, Zipris D.

Ann N Y Acad Sci. 2008 Dec;1150:139-42.PMID: 19120282 [PubMed - indexed for MEDLINE]Related articles

A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.

Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2006 Dec 1;177(11):7820-32.PMID: 17114453 [PubMed - indexed for MEDLINE]Related articlesFree article