PubMed

A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.

Lehman DM, Fu DJ, Freeman AB, Hunt KJ, Leach RJ, Johnson-Pais T, Hamlington J, Dyer TD, Arya R, Abboud H, Göring HH, Duggirala R, Blangero J, Konrad RJ, Stern MP.

Diabetes. 2005 Apr;54(4):1214-21.PMID: 15793264 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians.

Farook VS, Bogardus C, Prochazka M.

Mol Genet Metab. 2002 Sep-Oct;77(1-2):189-93.PMID: 12359146 [PubMed - indexed for MEDLINE]Related articles

Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.

Forsythe ME, Love DC, Lazarus BD, Kim EJ, Prinz WA, Ashwell G, Krause MW, Hanover JA.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11952-7. Epub 2006 Aug 1.PMID: 16882729 [PubMed - indexed for MEDLINE]Related articlesFree article

The hexosamine signaling pathway: deciphering the "O-GlcNAc code".

Love DC, Hanover JA.

Sci STKE. 2005 Nov 29;2005(312):re13. Review.PMID: 16317114 [PubMed - indexed for MEDLINE]Related articles

MGEA5-14 polymorphism and type 2 diabetes in Mexico City.

Cameron EA, Martinez-Marignac VL, Chan A, Valladares A, Simmonds LV, Wacher N, Kumate J, McKeigue P, Shriver MD, Kittles R, Cruz M, Parra EJ.

Am J Hum Biol. 2007 Jul-Aug;19(4):593-6.PMID: 17546623 [PubMed - indexed for MEDLINE]Related articles

Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.

Lehman DM, Hunt KJ, Leach RJ, Hamlington J, Arya R, Abboud HE, Duggirala R, Blangero J, Göring HH, Stern MP.

Diabetes. 2007 Feb;56(2):389-93.PMID: 17259383 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of genetic variation in ENPP1 with obesity-related phenotypes.

Jenkinson CP, Coletta DK, Flechtner-Mors M, Hu SL, Fourcaudot MJ, Rodriguez LM, Schneider J, Arya R, Stern MP, Blangero J, Duggirala R, DeFronzo RA.

Obesity (Silver Spring). 2008 Jul;16(7):1708-13. Epub 2008 May 8.PMID: 18464750 [PubMed - indexed for MEDLINE]Related articles

P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans.

Lehman DM, Richardson DK, Jenkinson CP, Hunt KJ, Dyer TD, Leach RJ, Arya R, Abboud HE, Blangero J, Duggirala R, Stern MP.

Diabetes. 2007 Feb;56(2):513-7.PMID: 17259399 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetogenic antibiotic streptozotocin modifies the tryptic digest pattern for peptides of the enzyme O-GlcNAc-selective N-acetyl-beta-d-glucosaminidase that contain amino acid residues essential for enzymatic activity.

Lee TN, Alborn WE, Knierman MD, Konrad RJ.

Biochem Pharmacol. 2006 Sep 14;72(6):710-8. Epub 2006 Jul 17.PMID: 16844097 [PubMed - indexed for MEDLINE]Related articles

Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate.

Kim EJ, Kang DO, Love DC, Hanover JA.

Carbohydr Res. 2006 Jun 12;341(8):971-82. Epub 2006 Apr 11.PMID: 16584714 [PubMed - indexed for MEDLINE]Related articles

Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study.

Hunt KJ, Lehman DM, Arya R, Fowler S, Leach RJ, Göring HH, Almasy L, Blangero J, Dyer TD, Duggirala R, Stern MP.

Diabetes. 2005 Sep;54(9):2655-62.PMID: 16123354 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a major gene for type II diabetes and linkage analyses with selected candidate genes in Mexican-Americans.

Stern MP, Mitchell BD, Blangero J, Reinhart L, Krammerer CM, Harrison CR, Shipman PA, O'Connell P, Frazier ML, MacCluer JW.

Diabetes. 1996 May;45(5):563-8.PMID: 8621004 [PubMed - indexed for MEDLINE]Related articles

Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase.

Wells L, Gao Y, Mahoney JA, Vosseller K, Chen C, Rosen A, Hart GW.

J Biol Chem. 2002 Jan 18;277(3):1755-61.PMID: 11788610 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus.

Thameem F, Puppala S, He X, Arar NH, Stern MP, Blangero J, Duggirala R, Abboud HE.

Metabolism. 2009 Oct;58(10):1496-502. Epub 2009 Jul 4.PMID: 19577778 [PubMed - indexed for MEDLINE]Related articles

Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis.

Das SK, Sharma NK, Chu WS, Wang H, Elbein SC.

BMC Med Genet. 2008 Mar 17;9:16.PMID: 18366646 [PubMed - indexed for MEDLINE]Related articlesFree article

The O-GlcNAcase theory of diabetes: commentary on a candidate gene for diabetes.

Kudlow JE.

Mol Genet Metab. 2002 Sep-Oct;77(1-2):1-2. No abstract available. PMID: 12359123 [PubMed - indexed for MEDLINE]Related articles

A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.

Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DM.

Cancer. 2006 Jun 15;106(12):2716-24.PMID: 16691626 [PubMed - indexed for MEDLINE]Related articlesFree article

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ.

J Biol Chem. 2005 Jul 8;280(27):25313-22. Epub 2005 Mar 28.PMID: 15795231 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells.

Hanover JA, Lai Z, Lee G, Lubas WA, Sato SM.

Arch Biochem Biophys. 1999 Feb 1;362(1):38-45.PMID: 9917327 [PubMed - indexed for MEDLINE]Related articles

Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase.

Comtesse N, Maldener E, Meese E.

Biochem Biophys Res Commun. 2001 May 11;283(3):634-40.PMID: 11341771 [PubMed - indexed for MEDLINE]Related articles