PubMed

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes.

Stalker TJ, Gong Y, Scalia R.

Diabetes. 2005 Apr;54(4):1132-40.PMID: 15793253 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel role for calpains in the endothelial dysfunction of hyperglycemia.

Stalker TJ, Skvarka CB, Scalia R.

FASEB J. 2003 Aug;17(11):1511-3. Epub 2003 Jun 3.PMID: 12824289 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain.

Scalia R, Gong Y, Berzins B, Zhao LJ, Sharma K.

Diabetes. 2007 Jul;56(7):1842-9. Epub 2007 Apr 19.PMID: 17446533 [PubMed - indexed for MEDLINE]Related articlesFree article

Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain.

Wang S, Peng Q, Zhang J, Liu L.

Cardiovasc Res. 2008 Nov 1;80(2):255-62. Epub 2008 Jun 30.PMID: 18591204 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice.

Molnar J, Yu S, Mzhavia N, Pau C, Chereshnev I, Dansky HM.

Circ Res. 2005 Jun 10;96(11):1178-84. Epub 2005 May 5.PMID: 15879311 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells.

Su Y, Block ER.

Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1204-12.PMID: 10835326 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

Averna M, Stifanese R, De Tullio R, Salamino F, Bertuccio M, Pontremoli S, Melloni E.

FEBS J. 2007 Dec;274(23):6116-27. Epub 2007 Oct 29.PMID: 17970747 [PubMed - indexed for MEDLINE]Related articles

Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats.

Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N.

Endocrinology. 2007 Jan;148(1):160-5. Epub 2006 Oct 5. Erratum in: Endocrinology. 2007 May;148(5):2055. PMID: 17023526 [PubMed - indexed for MEDLINE]Related articlesFree article

20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.

Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H1018-26. Epub 2007 Dec 21.PMID: 18156192 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats.

Schwaninger RM, Sun H, Mayhan WG.

Life Sci. 2003 Nov 14;73(26):3415-25.PMID: 14572882 [PubMed - indexed for MEDLINE]Related articles

Endothelial nitric oxide in diabetes mellitus: too much or not enough?

Farkas K, Sármán B, Jermendy G, Somogyi A.

Diabetes Nutr Metab. 2000 Oct;13(5):287-97. Review.PMID: 11105972 [PubMed - indexed for MEDLINE]Related articles

Chronic ethanol exposure stimulates endothelial cell nitric oxide production through PI-3 kinase-and hsp90-dependent mechanisms.

Polikandriotis JA, Rupnow HL, Hart CM.

Alcohol Clin Exp Res. 2005 Nov;29(11):1932-8.PMID: 16340449 [PubMed - indexed for MEDLINE]Related articles

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

Li X, Zhang L, Meshinchi S, Dias-Leme C, Raffin D, Johnson JD, Treutelaar MK, Burant CF.

Diabetes. 2006 Nov;55(11):2965-73.PMID: 17065332 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90.

Fulton D, Harris MB, Kemp BE, Venema RC, Marrero MB, Stepp DW.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2384-93. Epub 2004 Jul 22.PMID: 15271670 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

Davis BJ, Xie Z, Viollet B, Zou MH.

Diabetes. 2006 Feb;55(2):496-505.PMID: 16443786 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial nitric oxide synthase and endothelial dysfunction.

Huang PL.

Curr Hypertens Rep. 2003 Dec;5(6):473-80. Review.PMID: 14594566 [PubMed - indexed for MEDLINE]Related articles

Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes.

Oltman CL, Kleinschmidt TL, Davidson EP, Coppey LJ, Lund DD, Yorek MA.

Vascul Pharmacol. 2008 Jan;48(1):47-53. Epub 2007 Nov 29.PMID: 18164667 [PubMed - indexed for MEDLINE]Related articles

The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells.

Joy S, Siow RC, Rowlands DJ, Becker M, Wyatt AW, Aaronson PI, Coen CW, Kallo I, Jacob R, Mann GE.

J Biol Chem. 2006 Sep 15;281(37):27335-45. Epub 2006 Jul 13.PMID: 16840783 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic vasopeptidase inhibition normalizes diabetic endothelial dysfunction.

Schäfer S, Steioff K, Linz W, Bleich M, Busch AE, Löhn M.

Eur J Pharmacol. 2004 Jan 26;484(2-3):361-2.PMID: 14744624 [PubMed - indexed for MEDLINE]Related articles

Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution.

Whitsett J, Martásek P, Zhao H, Schauer DW, Hatakeyama K, Kalyanaraman B, Vásquez-Vivar J.

Free Radic Biol Med. 2006 Jun 1;40(11):2056-68. Epub 2006 Feb 20.PMID: 16716906 [PubMed - indexed for MEDLINE]Related articles