PubMed

PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance.

Kaneto H, Nakatani Y, Miyatsuka T, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y.

Diabetes. 2005 Apr;54(4):1009-22.PMID: 15793239 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver.

Wang AY, Ehrhardt A, Xu H, Kay MA.

Mol Ther. 2007 Feb;15(2):255-63.PMID: 17235302 [PubMed - indexed for MEDLINE]Related articles

Role of PDX-1 and MafA as a potential therapeutic target for diabetes.

Kaneto H, Miyatsuka T, Fujitani Y, Noguchi H, Song KH, Yoon KH, Matsuoka TA.

Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S127-37. Epub 2007 Apr 20. Review.PMID: 17449132 [PubMed - indexed for MEDLINE]Related articles

A crucial role of MafA as a novel therapeutic target for diabetes.

Kaneto H, Matsuoka TA, Nakatani Y, Miyatsuka T, Matsuhisa M, Hori M, Yamasaki Y.

J Biol Chem. 2005 Apr 15;280(15):15047-52. Epub 2005 Jan 20.PMID: 15664997 [PubMed - indexed for MEDLINE]Related articlesFree article

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells.

Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC.

J Endocrinol. 2009 Apr;201(1):37-47. Epub 2009 Jan 23.PMID: 19168505 [PubMed - indexed for MEDLINE]Related articles

The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells.

Peshavaria M, Cissell MA, Henderson E, Petersen HV, Stein R.

Mol Endocrinol. 2000 Dec;14(12):1907-17.PMID: 11117522 [PubMed - indexed for MEDLINE]Related articlesFree article

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.

Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L.

Nat Med. 2003 May;9(5):596-603. Epub 2003 Apr 21.PMID: 12704384 [PubMed - indexed for MEDLINE]Related articles

Forced expression of PDX-1 induces insulin production in intestinal epithelia.

Koizumi M, Nagai K, Kida A, Kami K, Ito D, Fujimoto K, Kawaguchi Y, Doi R.

Surgery. 2006 Aug;140(2):273-80.PMID: 16904980 [PubMed - indexed for MEDLINE]Related articles

Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.

Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC.

J Biol Chem. 2002 Apr 12;277(15):12998-3006. Epub 2002 Jan 17.PMID: 11799123 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice.

Kodama S, Toyonaga T, Kondo T, Matsumoto K, Tsuruzoe K, Kawashima J, Goto H, Kume K, Kume S, Sakakida M, Araki E.

Biochem Biophys Res Commun. 2005 Feb 25;327(4):1170-8.PMID: 15652518 [PubMed - indexed for MEDLINE]Related articles

Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation.

Tang DQ, Cao LZ, Chou W, Shun L, Farag C, Atkinson MA, Li SW, Chang LJ, Yang LJ.

Lab Invest. 2006 Aug;86(8):829-41. Epub 2006 May 29.PMID: 16732298 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells.

Kaneto H, Matsuoka TA, Katakami N, Matsuhisa M.

Curr Med Chem. 2009;16(24):3144-51. Review.PMID: 19689288 [PubMed - indexed for MEDLINE]Related articles

Glucose regulation of insulin gene expression in pancreatic beta-cells.

Andrali SS, Sampley ML, Vanderford NL, Ozcan S.

Biochem J. 2008 Oct 1;415(1):1-10. Review.PMID: 18778246 [PubMed - indexed for MEDLINE]Related articles

Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology.

Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi S.

Cell Transplant. 2006;15(10):929-38.PMID: 17299998 [PubMed - indexed for MEDLINE]Related articles

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P.

Diabetes. 2000 Feb;49(2):163-76.PMID: 10868931 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia.

Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A.

Nat Med. 2000 May;6(5):568-72.PMID: 10802714 [PubMed - indexed for MEDLINE]Related articles

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.

Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA.

J Clin Invest. 2009 Jul;119(7):1888-98.PMID: 19487809 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells.

Delisle JC, Martignat L, Dubreil L, Saï P, Bach JM, Louzier V, Bösch S.

BMC Res Notes. 2009 Jan 9;2:3.PMID: 19134185 [PubMed - in process]Related articlesFree article

Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase.

Lebrun P, Montminy MR, Van Obberghen E.

J Biol Chem. 2005 Nov 18;280(46):38203-10. Epub 2005 Sep 15.PMID: 16166097 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of MafA in pancreatic beta-cells.

Kaneto H, Matsuoka TA, Kawashima S, Yamamoto K, Kato K, Miyatsuka T, Katakami N, Matsuhisa M.

Adv Drug Deliv Rev. 2009 Jul 2;61(7-8):489-96. Epub 2009 Apr 22. Review.PMID: 19393272 [PubMed - indexed for MEDLINE]Related articles