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    Results: 1 to 20 of 198

    1.

    S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.

    Carvalho-Filho MA, Ueno M, Hirabara SM, Seabra AB, Carvalheira JB, de Oliveira MG, Velloso LA, Curi R, Saad MJ.

    Diabetes. 2005 Apr;54(4):959-67.PMID: 15793233 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice.

    Carvalho-Filho MA, Ueno M, Carvalheira JB, Velloso LA, Saad MJ.

    Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E476-82. Epub 2006 Apr 25.PMID: 16638822 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats.

    Pauli JR, Ropelle ER, Cintra DE, Carvalho-Filho MA, Moraes JC, De Souza CT, Velloso LA, Carvalheira JB, Saad MJ.

    J Physiol. 2008 Jan 15;586(2):659-71. Epub 2007 Nov 1.PMID: 17974582 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.

    Zhou J, Huang K.

    Toxicol Appl Pharmacol. 2009 Nov 15;241(1):101-10. Epub 2009 Aug 12.PMID: 19682478 [PubMed - indexed for MEDLINE]Related articles

    5.

    Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.

    Dokken BB, Sloniger JA, Henriksen EJ.

    Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1188-94. Epub 2005 Jan 25.PMID: 15671078 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

    Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG.

    Life Sci. 2005 Oct 28;77(24):3068-77. Epub 2005 Jun 27.PMID: 15982669 [PubMed - indexed for MEDLINE]Related articles

    7.

    Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes.

    Rojas FA, Hirata AE, Saad MJ.

    Mol Cell Endocrinol. 2001 Oct 25;183(1-2):63-9.PMID: 11604226 [PubMed - indexed for MEDLINE]Related articles

    8.

    S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.

    Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M.

    J Biol Chem. 2005 Mar 4;280(9):7511-8. Epub 2005 Jan 4.PMID: 15632167 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.

    Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M.

    J Biol Chem. 2005 Apr 8;280(14):14203-11. Epub 2005 Feb 1.PMID: 15805118 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists.

    Jiang G, Dallas-Yang Q, Li Z, Szalkowski D, Liu F, Shen X, Wu M, Zhou G, Doebber T, Berger J, Moller DE, Zhang BB.

    Diabetes. 2002 Aug;51(8):2412-9.PMID: 12145152 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

    Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

    Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo.

    Campbell CS, Caperuto LC, Hirata AE, Araujo EP, Velloso LA, Saad MJ, Carvalho CR.

    Life Sci. 2004 Nov 19;76(1):57-70.PMID: 15501480 [PubMed - indexed for MEDLINE]Related articles

    13.

    Nitrosative stress and pathogenesis of insulin resistance.

    Kaneki M, Shimizu N, Yamada D, Chang K.

    Antioxid Redox Signal. 2007 Mar;9(3):319-29. Review.PMID: 17184170 [PubMed - indexed for MEDLINE]Related articles

    14.

    Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.

    Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV Jr, Farese RV.

    J Biol Chem. 2004 Jun 11;279(24):24929-34. Epub 2004 Apr 6.PMID: 15069067 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt.

    Carvalho-Filho MA, Ropelle ER, Pauli RJ, Cintra DE, Tsukumo DM, Silveira LR, Curi R, Carvalheira JB, Velloso LA, Saad MJ.

    Diabetologia. 2009 Sep 3. [Epub ahead of print]PMID: 19730809 [PubMed - as supplied by publisher]Related articles

    16.

    Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.

    Shen Q, Cline GW, Shulman GI, Leibowitz MD, Davies PJ.

    J Biol Chem. 2004 May 7;279(19):19721-31. Epub 2004 Mar 2.PMID: 14998989 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Endurance exercise training increases insulin responsiveness in isolated adipocytes through IRS/PI3-kinase/Akt pathway.

    Peres SB, de Moraes SM, Costa CE, Brito LC, Takada J, Andreotti S, Machado MA, Alonso-Vale MI, Borges-Silva CN, Lima FB.

    J Appl Physiol. 2005 Mar;98(3):1037-43. Epub 2004 Nov 5.PMID: 15531568 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart.

    Desrois M, Sidell RJ, Gauguier D, King LM, Radda GK, Clarke K.

    Cardiovasc Res. 2004 Feb 1;61(2):288-96.PMID: 14736545 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance.

    Duan C, Yang H, White MF, Rui L.

    Mol Cell Biol. 2004 Sep;24(17):7435-43.PMID: 15314154 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase.

    Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE.

    Biochemistry. 2004 May 18;43(19):5637-50.PMID: 15134438 [PubMed - indexed for MEDLINE]Related articles

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