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    Results: 1 to 20 of 189

    1.

    N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice.

    Shibuya K, Kanasaki K, Isono M, Sato H, Omata M, Sugimoto T, Araki S, Isshiki K, Kashiwagi A, Haneda M, Koya D.

    Diabetes. 2005 Mar;54(3):838-45.PMID: 15734863 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells.

    Kanasaki K, Koya D, Sugimoto T, Isono M, Kashiwagi A, Haneda M.

    J Am Soc Nephrol. 2003 Apr;14(4):863-72.PMID: 12660320 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice.

    Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K.

    Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8015-20.PMID: 10859350 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse.

    Hong SW, Isono M, Chen S, Iglesias-De La Cruz MC, Han DC, Ziyadeh FN.

    Am J Pathol. 2001 May;158(5):1653-63.PMID: 11337363 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis.

    Omata M, Taniguchi H, Koya D, Kanasaki K, Sho R, Kato Y, Kojima R, Haneda M, Inomata N.

    J Am Soc Nephrol. 2006 Mar;17(3):674-85. Epub 2006 Feb 1.PMID: 16452498 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells.

    Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN.

    Biochem Biophys Res Commun. 2002 Sep 6;296(5):1356-65.PMID: 12207925 [PubMed - indexed for MEDLINE]Related articles

    7.

    Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria.

    Wang A, Ziyadeh FN, Lee EY, Pyagay PE, Sung SH, Sheardown SA, Laping NJ, Chen S.

    Am J Physiol Renal Physiol. 2007 Nov;293(5):F1657-65. Epub 2007 Sep 5.PMID: 17804483 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes.

    Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, Kikkawa R.

    FASEB J. 2000 Mar;14(3):439-47.PMID: 10698958 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    N-acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators.

    Kanasaki K, Haneda M, Sugimoto T, Shibuya K, Isono M, Isshiki K, Araki S, Uzu T, Kashiwagi A, Koya D.

    Biochem Biophys Res Commun. 2006 Apr 14;342(3):758-65. Epub 2006 Feb 17.PMID: 16497271 [PubMed - indexed for MEDLINE]Related articles

    10.

    Antifibrotic effects of N-acetyl-seryl-aspartyl-Lysyl-proline on the heart and kidney in aldosterone-salt hypertensive rats.

    Peng H, Carretero OA, Raij L, Yang F, Kapke A, Rhaleb NE.

    Hypertension. 2001 Feb;37(2 Part 2):794-800.PMID: 11230375 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.

    Liu YH, D'Ambrosio M, Liao TD, Peng H, Rhaleb NE, Sharma U, André S, Gabius HJ, Carretero OA.

    Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H404-12. Epub 2008 Dec 19.PMID: 19098114 [PubMed - indexed for MEDLINE]Related articles

    12.

    Effects of candesartan, an angiotensin II type 1 receptor blocker, on diabetic nephropathy in KK/Ta mice.

    Liao J, Kobayashi M, Kanamuru Y, Nakamura S, Makita Y, Funabiki K, Horikoshi S, Tomino Y.

    J Nephrol. 2003 Nov-Dec;16(6):841-9.PMID: 14736011 [PubMed - indexed for MEDLINE]Related articles

    13.

    Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension.

    Rasoul S, Carretero OA, Peng H, Cavasin MA, Zhuo J, Sanchez-Mendoza A, Brigstock DR, Rhaleb NE.

    J Hypertens. 2004 Mar;22(3):593-603.PMID: 15076166 [PubMed - indexed for MEDLINE]Related articles

    14.

    p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency.

    Wolf G, Schanze A, Stahl RA, Shankland SJ, Amann K.

    Kidney Int. 2005 Oct;68(4):1583-9.PMID: 16164635 [PubMed - indexed for MEDLINE]Related articles

    15.

    SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice.

    Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M.

    Am J Physiol Renal Physiol. 2006 Apr;290(4):F813-20. Epub 2005 Nov 8.PMID: 16278277 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts.

    Rhaleb NE, Peng H, Harding P, Tayeh M, LaPointe MC, Carretero OA.

    Hypertension. 2001 Mar;37(3):827-32.PMID: 11244003 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension.

    Peng H, Carretero OA, Brigstock DR, Oja-Tebbe N, Rhaleb NE.

    Hypertension. 2003 Dec;42(6):1164-70. Epub 2003 Oct 27.PMID: 14581293 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice.

    Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN.

    Biochem Biophys Res Commun. 2003 Jan 3;300(1):16-22.PMID: 12480514 [PubMed - indexed for MEDLINE]Related articles

    19.

    Inhibiting albumin glycation ameliorates diabetic nephropathy in the db/db mouse.

    Cohen MP, Masson N, Hud E, Ziyadeh F, Han DC, Clements RS.

    Exp Nephrol. 2000 May-Jun;8(3):135-43.PMID: 10810230 [PubMed - indexed for MEDLINE]Related articles

    20.

    Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.

    Lin CX, Rhaleb NE, Yang XP, Liao TD, D'Ambrosio MA, Carretero OA.

    Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1253-H1261. Epub 2008 Jul 18.PMID: 18641275 [PubMed - indexed for MEDLINE]Related articlesFree article

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