PubMed

Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism.

Redondo S, Ruiz E, Santos-Gallego CG, Padilla E, Tejerina T.

Diabetes. 2005 Mar;54(3):811-7.PMID: 15734860 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone induces apoptosis in human vascular smooth muscle cells from diabetic patients involving the transforming growth factor-beta/activin receptor-like kinase-4/5/7/Smad2 signaling pathway.

Ruiz E, Redondo S, Gordillo-Moscoso A, Tejerina T.

J Pharmacol Exp Ther. 2007 May;321(2):431-8. Epub 2007 Jan 31.PMID: 17267584 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cells.

Guo B, Koya D, Isono M, Sugimoto T, Kashiwagi A, Haneda M.

Diabetes. 2004 Jan;53(1):200-8.PMID: 14693716 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis.

Gao DF, Niu XL, Hao GH, Peng N, Wei J, Ning N, Wang NP.

Biochem Pharmacol. 2007 Jan 15;73(2):185-97. Epub 2006 Sep 23.PMID: 17074304 [PubMed - indexed for MEDLINE]Related articles

Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads.

Fu M, Zhang J, Lin Y, Zhu X, Zhao L, Ahmad M, Ehrengruber MU, Chen YE.

Biochem J. 2003 Mar 15;370(Pt 3):1019-25.PMID: 12457461 [PubMed - indexed for MEDLINE]Related articlesFree article

Biphasic effect of pioglitazone on isolated human endothelial progenitor cells: involvement of peroxisome proliferator-activated receptor-gamma and transforming growth factor-beta1.

Redondo S, Hristov M, Gümbel D, Tejerina T, Weber C.

Thromb Haemost. 2007 Jun;97(6):979-87.PMID: 17549301 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone inhibits homocysteine-induced migration of vascular smooth muscle cells through a peroxisome proliferator-activated receptor gamma-independent mechanism.

Li L, Gao PJ, Xi R, Wu CF, Zhu DL, Yan J, Lu GP.

Clin Exp Pharmacol Physiol. 2008 Dec;35(12):1471-6. Epub 2008 Aug 26.PMID: 18759864 [PubMed - indexed for MEDLINE]Related articles

Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.

Jeon ES, Moon HJ, Lee MJ, Song HY, Kim YM, Bae YC, Jung JS, Kim JH.

J Cell Sci. 2006 Dec 1;119(Pt 23):4994-5005. Epub 2006 Nov 14.PMID: 17105765 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts.

Zafiriou S, Stanners SR, Saad S, Polhill TS, Poronnik P, Pollock CA.

J Am Soc Nephrol. 2005 Mar;16(3):638-45. Epub 2005 Feb 2.PMID: 15689403 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells.

Okura T, Nakamura M, Takata Y, Watanabe S, Kitami Y, Hiwada K.

Eur J Pharmacol. 2000 Nov 3;407(3):227-35.PMID: 11068018 [PubMed - indexed for MEDLINE]Related articles

Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells.

Zheng S, Chen A.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G113-23. Epub 2006 Sep 7.PMID: 16959952 [PubMed - indexed for MEDLINE]Related articlesFree article

[Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts]

Wang WM, Liu F, Chen N.

Zhonghua Yi Xue Za Zhi. 2006 Mar 21;86(11):740-4. Chinese. PMID: 16681946 [PubMed - indexed for MEDLINE]Related articles

Troglitazone inhibits synthesis of transforming growth factor-beta1 and reduces matrix production in human peritoneal mesothelial cells.

Peng Y, Liu H, Liu F, Liu Y, Li J, Chen X.

Nephrology (Carlton). 2006 Dec;11(6):516-23.PMID: 17199790 [PubMed - indexed for MEDLINE]Related articles

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma.

Ghosh AK, Wei J, Wu M, Varga J.

Biochem Biophys Res Commun. 2008 Sep 19;374(2):231-6. Epub 2008 Jul 15.PMID: 18627765 [PubMed - indexed for MEDLINE]Related articles

hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists.

Li Y, Wen X, Spataro BC, Hu K, Dai C, Liu Y.

J Am Soc Nephrol. 2006 Jan;17(1):54-65. Epub 2005 Nov 16.PMID: 16291834 [PubMed - indexed for MEDLINE]Related articlesFree article

The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway.

Heeg MH, Koziolek MJ, Vasko R, Schaefer L, Sharma K, Müller GA, Strutz F.

Kidney Int. 2005 Jul;68(1):96-109.PMID: 15954899 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism.

Rodríguez-Vita J, Sánchez-López E, Esteban V, Rupérez M, Egido J, Ruiz-Ortega M.

Circulation. 2005 May 17;111(19):2509-17. Epub 2005 May 9.PMID: 15883213 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts.

Zhang GY, Yi CG, Li X, Ma B, Li ZJ, Chen XL, Guo SZ, Gao WY.

Br J Dermatol. 2009 Apr;160(4):762-70. Epub 2008 Dec 2.PMID: 19120328 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-gamma ligand reduced tumor necrosis factor-alpha-induced interleukin-8 production and growth in endometriotic stromal cells.

Ohama Y, Harada T, Iwabe T, Taniguchi F, Takenaka Y, Terakawa N.

Fertil Steril. 2008 Feb;89(2):311-7. Epub 2007 Jun 6.PMID: 17555752 [PubMed - indexed for MEDLINE]Related articles

Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes.

Poleni PE, Bianchi A, Etienne S, Koufany M, Sebillaud S, Netter P, Terlain B, Jouzeau JY.

Osteoarthritis Cartilage. 2007 May;15(5):493-505. Epub 2006 Nov 29.PMID: 17140817 [PubMed - indexed for MEDLINE]Related articles