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Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans.

Raju B, Cryer PE.

Diabetes. 2005 Mar;54(3):757-64.PMID: 15734853 [PubMed - indexed for MEDLINE]Related articlesFree article

Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response.

Banarer S, McGregor VP, Cryer PE.

Diabetes. 2002 Apr;51(4):958-65.PMID: 11916913 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans.

Gosmanov NR, Szoke E, Israelian Z, Smith T, Cryer PE, Gerich JE, Meyer C.

Diabetes Care. 2005 May;28(5):1124-31.PMID: 15855577 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes.

Israelian Z, Gosmanov NR, Szoke E, Schorr M, Bokhari S, Cryer PE, Gerich JE, Meyer C.

Diabetes Care. 2005 Nov;28(11):2691-6.PMID: 16249541 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia.

Bolli G, De Feo P, Perriello G, De Cosmo S, Compagnucci P, Santeusanio F, Brunetti P, Unger RH.

J Clin Invest. 1984 Apr;73(4):917-22.PMID: 6368593 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans.

Peacey SR, Rostami-Hodjegan A, George E, Tucker GT, Heller SR.

J Clin Endocrinol Metab. 1997 May;82(5):1458-61.PMID: 9141533 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemia-associated autonomic failure in advanced type 2 diabetes.

Segel SA, Paramore DS, Cryer PE.

Diabetes. 2002 Mar;51(3):724-33.PMID: 11872673 [PubMed - indexed for MEDLINE]Related articlesFree article

Residual insulin secretion is not coupled to a maintained glucagon response to hypoglycaemia in long-term type 1 diabetes.

Sjöberg S, Ahrén B, Bolinder J.

J Intern Med. 2002 Oct;252(4):342-51.PMID: 12366607 [PubMed - indexed for MEDLINE]Related articles

Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia.

McGregor VP, Banarer S, Cryer PE.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E770-7.PMID: 11882496 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory capacity and the regulation of glucagon secretion in diabetic and non-diabetic alcoholic cirrhotic patients.

Kruszynska YT, Goulas S, Wollen N, McIntyre N.

J Hepatol. 1998 Feb;28(2):280-91.PMID: 9514541 [PubMed - indexed for MEDLINE]Related articles

Pancreatic alpha-cell function in idiopathic reactive hypoglycemia.

Ahmadpour S, Kabadi UM.

Metabolism. 1997 Jun;46(6):639-43.PMID: 9186298 [PubMed - indexed for MEDLINE]Related articles

Limited impact of vigorous exercise on defenses against hypoglycemia: relevance to hypoglycemia-associated autonomic failure.

McGregor VP, Greiwe JS, Banarer S, Cryer PE.

Diabetes. 2002 May;51(5):1485-92.PMID: 11978646 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia.

Szoke E, Gosmanov NR, Sinkin JC, Nihalani A, Fender AB, Cryer PE, Meyer C, Gerich JE.

Metabolism. 2006 Jan;55(1):78-83.PMID: 16324923 [PubMed - indexed for MEDLINE]Related articles

Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.

Hussain K, Bryan J, Christesen HT, Brusgaard K, Aguilar-Bryan L.

Diabetes. 2005 Oct;54(10):2946-51.PMID: 16186397 [PubMed - indexed for MEDLINE]Related articlesFree article

Autonomic mediation of glucagon secretion during insulin-induced hypoglycemia in rhesus monkeys.

Havel PJ, Valverde C.

Diabetes. 1996 Jul;45(7):960-6.PMID: 8666149 [PubMed - indexed for MEDLINE]Related articles

Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes.

Landstedt-Hallin L, Adamson U, Lins PE.

J Clin Endocrinol Metab. 1999 Sep;84(9):3140-5.PMID: 10487677 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of autonomic nerves and the adrenal medulla contributes to increased glucagon secretion during moderate insulin-induced hypoglycemia in women.

Havel PJ, Ahren B.

Diabetes. 1997 May;46(5):801-7.PMID: 9133547 [PubMed - indexed for MEDLINE]Related articles

Multiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus.

Israelian Z, Szoke E, Woerle J, Bokhari S, Schorr M, Schwenke DC, Cryer PE, Gerich JE, Meyer C.

Metabolism. 2006 May;55(5):593-8.PMID: 16631434 [PubMed - indexed for MEDLINE]Related articles

Effects of diazoxide on alpha- and beta-cell function in isolated perfused rat pancreas.

Hirose H, Maruyama H, Ito K, Kido K, Koyama K, Saruta T.

Diabetes Res Clin Pract. 1994 Sep;25(2):77-82.PMID: 7821194 [PubMed - indexed for MEDLINE]Related articles

Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia.

Degn KB, Brock B, Juhl CB, Djurhuus CB, Grubert J, Kim D, Han J, Taylor K, Fineman M, Schmitz O.

Diabetes. 2004 Sep;53(9):2397-403.PMID: 15331551 [PubMed - indexed for MEDLINE]Related articlesFree article