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    Results: 1 to 20 of 147

    1.

    Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.

    Zhang X, Gaspard JP, Mizukami Y, Li J, Graeme-Cook F, Chung DC.

    Diabetes. 2005 Mar;54(3):712-9.PMID: 15734847 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.

    Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF.

    Mol Cell Biol. 2005 May;25(9):3752-62.PMID: 15831479 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes.

    Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C, Barbacid M, Gomis R.

    Diabetologia. 2004 Apr;47(4):686-94.PMID: 15298346 [PubMed - indexed for MEDLINE]Related articles

    4.

    Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.

    Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF.

    Diabetes. 2009 Apr;58(4):882-93. Epub 2009 Jan 9.PMID: 19136653 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.

    Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.

    Diabetologia. 2004 Oct;47(10):1819-30. Epub 2004 Oct 6.PMID: 15480536 [PubMed - indexed for MEDLINE]Related articles

    6.

    Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

    Vasavada RC, Garcia-Ocaña A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, Stewart AF.

    J Biol Chem. 2000 May 19;275(20):15399-406.PMID: 10809775 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.

    Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.

    J Biol Chem. 2000 Jan 14;275(2):1226-32.PMID: 10625667 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes.

    Robertson K, Lu Y, De Jesus K, Li B, Su Q, Lund PK, Liu JL.

    Am J Physiol Endocrinol Metab. 2008 May;294(5):E928-38. Epub 2008 Feb 12.PMID: 18270301 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line.

    Biliran H Jr, Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bollig A, Sarkar FH, Liao JD.

    Clin Cancer Res. 2005 Aug 15;11(16):6075-86.PMID: 16115953 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Overexpression of parathyroid hormone-related protein inhibits pancreatic beta-cell death in vivo and in vitro.

    Cebrian A, García-Ocaña A, Takane KK, Sipula D, Stewart AF, Vasavada RC.

    Diabetes. 2002 Oct;51(10):3003-13.PMID: 12351440 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

    Friedrichsen BN, Neubauer N, Lee YC, Gram VK, Blume N, Petersen JS, Nielsen JH, Møldrup A.

    J Endocrinol. 2006 Mar;188(3):481-92.PMID: 16522728 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.

    Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E.

    Diabetes. 2006 Feb;55(2):318-25.PMID: 16443763 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Exendin-4 induction of cyclin D1 expression in INS-1 beta-cells: involvement of cAMP-responsive element.

    Kim MJ, Kang JH, Park YG, Ryu GR, Ko SH, Jeong IK, Koh KH, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH.

    J Endocrinol. 2006 Mar;188(3):623-33.PMID: 16522741 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells.

    Inada A, Hamamoto Y, Tsuura Y, Miyazaki J, Toyokuni S, Ihara Y, Nagai K, Yamada Y, Bonner-Weir S, Seino Y.

    Mol Cell Biol. 2004 Apr;24(7):2831-41.PMID: 15024072 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Glucose-dependent expansion of pancreatic beta-cells by the protein p8 in vitro and in vivo.

    Päth G, Opel A, Gehlen M, Rothhammer V, Niu X, Limbert C, Romfeld L, Hügl S, Knoll A, Brendel MD, Bretzel RG, Seufert J.

    Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1168-76. Epub 2006 Jul 5.PMID: 16822955 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    p16INK4a induces an age-dependent decline in islet regenerative potential.

    Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE.

    Nature. 2006 Sep 28;443(7110):453-7. Epub 2006 Sep 6.PMID: 16957737 [PubMed - indexed for MEDLINE]Related articles

    17.

    Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.

    Ouyang W, Ma Q, Li J, Zhang D, Liu ZG, Rustgi AK, Huang C.

    Cancer Res. 2005 Oct 15;65(20):9287-93.PMID: 16230390 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.

    Schnepp RW, Chen YX, Wang H, Cash T, Silva A, Diehl JA, Brown E, Hua X.

    Cancer Res. 2006 Jun 1;66(11):5707-15.PMID: 16740708 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.

    Inada A, Weir GC, Bonner-Weir S.

    Biochem Biophys Res Commun. 2005 Apr 15;329(3):925-9.PMID: 15752744 [PubMed - indexed for MEDLINE]Related articles

    20.

    Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development.

    Skapek SX, Lin SC, Jablonski MM, McKeller RN, Tan M, Hu N, Lee EY.

    Oncogene. 2001 Oct 11;20(46):6742-51.PMID: 11709709 [PubMed - indexed for MEDLINE]Related articlesFree article

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