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Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism.

Hampson LJ, Agius L.

Diabetes. 2005 Mar;54(3):617-23.PMID: 15734835 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose.

Aiston S, Green A, Mukhtar M, Agius L.

Biochem J. 2004 Jan 1;377(Pt 1):195-204.PMID: 13678417 [PubMed - indexed for MEDLINE]Related articlesFree article

The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.

Green AR, Aiston S, Greenberg CC, Freeman S, Poucher SM, Brady MJ, Agius L.

J Biol Chem. 2004 Nov 5;279(45):46474-82. Epub 2004 Aug 18.PMID: 15322104 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

Aiston S, Hampson L, Gómez-Foix AM, Guinovart JJ, Agius L.

J Biol Chem. 2001 Jun 29;276(26):23858-66. Epub 2001 Apr 17.PMID: 11309391 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase.

Aiston S, Andersen B, Agius L.

Diabetes. 2003 Jun;52(6):1333-9.PMID: 12765941 [PubMed - indexed for MEDLINE]Related articlesFree article

Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes.

Latsis T, Andersen B, Agius L.

Biochem J. 2002 Nov 15;368(Pt 1):309-16.PMID: 12186629 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.

Aiston S, Coghlan MP, Agius L.

Eur J Biochem. 2003 Jul;270(13):2773-81.PMID: 12823547 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L.

Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R766-74. Epub 2008 Jan 16.PMID: 18199594 [PubMed - indexed for MEDLINE]Related articles

Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.

Gomis RR, Favre C, García-Rocha M, Fernández-Novell JM, Ferrer JC, Guinovart JJ.

J Biol Chem. 2003 Mar 14;278(11):9740-6. Epub 2003 Jan 7.PMID: 12519761 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms.

Longnus SL, Wambolt RB, Parsons HL, Brownsey RW, Allard MF.

Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R936-44.PMID: 12626360 [PubMed - indexed for MEDLINE]Related articles

Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite.

Bergans N, Stalmans W, Goldmann S, Vanstapel F.

Diabetes. 2000 Sep;49(9):1419-26.PMID: 10969824 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.

Hampson LJ, Mackin P, Agius L.

Diabetologia. 2007 Aug;50(8):1743-51. Epub 2007 Jun 20.PMID: 17579833 [PubMed - indexed for MEDLINE]Related articles

Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes.

Gustafson LA, Neeft M, Reijngoud DJ, Kuipers F, Sauerwein HP, Romijn JA, Herling AW, Burger HJ, Meijer AJ.

Biochem J. 2001 Sep 15;358(Pt 3):665-71.PMID: 11535127 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates.

Shang J, Lehrman MA.

J Biol Chem. 2004 Mar 26;279(13):12076-80. Epub 2004 Jan 16.PMID: 14729664 [PubMed - indexed for MEDLINE]Related articlesFree article

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.

Hampson LJ, Arden C, Agius L, Ganotidis M, Kosmopoulou MN, Tiraidis C, Elemes Y, Sakarellos C, Leonidas DD, Oikonomakos NG.

Bioorg Med Chem. 2006 Dec 1;14(23):7835-45.PMID: 16908161 [PubMed - indexed for MEDLINE]Related articles

Role of AMP on the activation of glycogen synthase and phosphorylase by adenosine, fructose, and glutamine in rat hepatocytes.

Carabaza A, Ricart MD, Mor A, Guinovart JJ, Ciudad CJ.

J Biol Chem. 1990 Feb 15;265(5):2724-32.PMID: 2105932 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase and molecular aspects of liver glycogen metabolism.

Agius L.

Biochem J. 2008 Aug 15;414(1):1-18. Review.PMID: 18651836 [PubMed - indexed for MEDLINE]Related articles

Inhibition of insulin-stimulated glycogen synthesis by 5-aminoimidasole-4-carboxamide-1-beta-d-ribofuranoside-induced adenosine 5'-monophosphate-activated protein kinase activation: interactions with Akt, glycogen synthase kinase 3-3alpha/beta, and glycogen synthase in isolated rat soleus muscle.

Fediuc S, Gaidhu MP, Ceddia RB.

Endocrinology. 2006 Nov;147(11):5170-7. Epub 2006 Jul 27.PMID: 16873531 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism.

Härndahl L, Schmoll D, Herling AW, Agius L.

FEBS J. 2006 Jan;273(2):336-46.PMID: 16403021 [PubMed - indexed for MEDLINE]Related articles

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

Guigas B, Bertrand L, Taleux N, Foretz M, Wiernsperger N, Vertommen D, Andreelli F, Viollet B, Hue L.

Diabetes. 2006 Apr;55(4):865-74.PMID: 16567505 [PubMed - indexed for MEDLINE]Related articlesFree article