PubMed

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes.

Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI.

Diabetes. 2005 Mar;54(3):603-8.PMID: 15734833 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA.

Gastroenterology. 2007 Aug;133(2):496-506. Epub 2007 May 1.PMID: 17681171 [PubMed - indexed for MEDLINE]Related articles

Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model.

Koopmans SJ, Mroz Z, Dekker R, Corbijn H, Ackermans M, Sauerwein H.

Metabolism. 2006 Jul;55(7):960-71.PMID: 16784971 [PubMed - indexed for MEDLINE]Related articles

Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes.

Perseghin G, Lattuada G, De Cobelli F, Esposito A, Costantino F, Canu T, Scifo P, De Taddeo F, Maffi P, Secchi A, Del Maschio A, Luzi L.

Diabetologia. 2005 Dec;48(12):2615-21. Epub 2005 Nov 1.PMID: 16261312 [PubMed - indexed for MEDLINE]Related articles

Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals.

Koska J, Stefan N, Permana PA, Weyer C, Sonoda M, Bogardus C, Smith SR, Joanisse DR, Funahashi T, Krakoff J, Bunt JC.

Am J Clin Nutr. 2008 Feb;87(2):295-302.PMID: 18258617 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects.

Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H, Maehara T, Kyogoku S, Sunayama S, Sato H, Hirose T, Tanaka Y, Kawamori R.

J Clin Endocrinol Metab. 2007 Aug;92(8):3326-9. Epub 2007 May 22.PMID: 17519317 [PubMed - indexed for MEDLINE]Related articlesFree article

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.

Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K.

N Engl J Med. 2006 Nov 30;355(22):2297-307.PMID: 17135584 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.

Petersen KF, Dufour S, Shulman GI.

PLoS Med. 2005 Sep;2(9):e233. Epub 2005 Aug 16.PMID: 16089501 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI.

N Engl J Med. 2004 Feb 12;350(7):664-71.PMID: 14960743 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.

Krssak M, Brehm A, Bernroider E, Anderwald C, Nowotny P, Dalla Man C, Cobelli C, Cline GW, Shulman GI, Waldhäusl W, Roden M.

Diabetes. 2004 Dec;53(12):3048-56.PMID: 15561933 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.

Henriksen JE, Levin K, Thye-Rønn P, Alford F, Hother-Nielsen O, Holst JJ, Beck-Nielsen H.

Diabetes. 2000 Jul;49(7):1209-18.PMID: 10909980 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance, but normal basal rates of glucose production in patients with newly diagnosed mild diabetes mellitus.

Hother-Nielsen O, Beck-Nielsen H.

Acta Endocrinol (Copenh). 1991 Jun;124(6):637-45.PMID: 2068893 [PubMed - indexed for MEDLINE]Related articles

Recombinant human insulin-like growth factor I treatment for 1 week improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance.

Cusi K, DeFronzo R.

J Clin Endocrinol Metab. 2000 Sep;85(9):3077-84.PMID: 10999789 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessment of hepatic insulin action in obese type 2 diabetic patients.

Staehr P, Hother-Nielsen O, Levin K, Holst JJ, Beck-Nielsen H.

Diabetes. 2001 Jun;50(6):1363-70.PMID: 11375337 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects.

Lara-Castro C, Newcomer BR, Rowell J, Wallace P, Shaughnessy SM, Munoz AJ, Shiflett AM, Rigsby DY, Lawrence JC, Bohning DE, Buchthal S, Garvey WT.

Metabolism. 2008 Jan;57(1):1-8.PMID: 18078853 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle.

Anderwald C, Bernroider E, Krssak M, Stingl H, Brehm A, Bischof MG, Nowotny P, Roden M, Waldhäusl W.

Diabetes. 2002 Oct;51(10):3025-32.PMID: 12351443 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes.

Bajaj M, Suraamornkul S, Pratipanawatr T, Hardies LJ, Pratipanawatr W, Glass L, Cersosimo E, Miyazaki Y, DeFronzo RA.

Diabetes. 2003 Jun;52(6):1364-70.PMID: 12765945 [PubMed - indexed for MEDLINE]Related articlesFree article

The determinants of glycemic responses to diet restriction and weight loss in obesity and NIDDM.

Markovic TP, Jenkins AB, Campbell LV, Furler SM, Kraegen EW, Chisholm DJ.

Diabetes Care. 1998 May;21(5):687-94.PMID: 9589225 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion and insulin sensitivity defects are a common feature of mild, clinically homogeneous, recently diagnosed type II (non-insulin-dependent) diabetics.

Pisu E, Lombardi A, De Benedictis D, Bozzo C, Chiara E, Baggiore C, Bruno A, Cravero L, Pagano G, Lenti G.

Acta Diabetol Lat. 1986 Jul-Sep;23(3):215-25.PMID: 3538736 [PubMed - indexed for MEDLINE]Related articles

Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes.

Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Järvinen H.

Gastroenterology. 2008 Jul;135(1):122-30. Epub 2008 Mar 21.PMID: 18474251 [PubMed - indexed for MEDLINE]Related articles