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A randomized, controlled trial of combination therapy for chronic hepatitis B: comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone.

Chan HL, Leung NW, Hui AY, Wong VW, Liew CT, Chim AM, Chan FK, Hung LC, Lee YT, Tam JS, Lam CW, Sung JJ.

Ann Intern Med. 2005 Feb 15;142(4):240-50.PMID: 15710957 [PubMed - indexed for MEDLINE]Related articlesFree article

Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B.

Lau GK, Piratvisuth T, Luo KX, Marcellin P, Thongsawat S, Cooksley G, Gane E, Fried MW, Chow WC, Paik SW, Chang WY, Berg T, Flisiak R, McCloud P, Pluck N; Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group.

N Engl J Med. 2005 Jun 30;352(26):2682-95.PMID: 15987917 [PubMed - indexed for MEDLINE]Related articlesFree article

Peginterferon alfa-2b as monotherapy or in combination with lamivudine in patients with HBeAg-negative chronic hepatitis B: a randomised study.

Papadopoulos VP, Chrysagis DN, Protopapas AN, Goulis IG, Dimitriadis GT, Mimidis KP.

Med Sci Monit. 2009 Feb;15(2):CR56-61.PMID: 19179968 [PubMed - indexed for MEDLINE]Related articlesFree article

Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial.

Janssen HL, van Zonneveld M, Senturk H, Zeuzem S, Akarca US, Cakaloglu Y, Simon C, So TM, Gerken G, de Man RA, Niesters HG, Zondervan P, Hansen B, Schalm SW; HBV 99-01 Study Group; Rotterdam Foundation for Liver Research.

Lancet. 2005 Jan 8-14;365(9454):123-9.PMID: 15639293 [PubMed - indexed for MEDLINE]Related articles

Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B.

Marcellin P, Lau GK, Bonino F, Farci P, Hadziyannis S, Jin R, Lu ZM, Piratvisuth T, Germanidis G, Yurdaydin C, Diago M, Gurel S, Lai MY, Button P, Pluck N; Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study Group.

N Engl J Med. 2004 Sep 16;351(12):1206-17.PMID: 15371578 [PubMed - indexed for MEDLINE]Related articlesFree article

Lamivudine/pegylated interferon alfa-2b sequential combination therapy compared with lamivudine monotherapy in HBeAg-negative chronic hepatitis B.

Vassiliadis T, Tziomalos K, Patsiaoura K, Zagris T, Giouleme O, Soufleris K, Grammatikos N, Theodoropoulos K, Mpoumponaris A, Dona K, Zezos P, Nikolaidis N, Orfanou-Koumerkeridou E, Balaska A, Eugenidis N.

J Gastroenterol Hepatol. 2007 Oct;22(10):1582-8. Epub 2007 Aug 7.PMID: 17683500 [PubMed - indexed for MEDLINE]Related articles

Higher efficacy of sequential therapy with interferon-alpha and lamivudine combination compared to lamivudine monotherapy in HBeAg positive chronic hepatitis B patients.

Sarin SK, Kumar M, Kumar R, Kazim SN, Guptan RC, Sakhuja P, Sharma BC.

Am J Gastroenterol. 2005 Nov;100(11):2463-71.PMID: 16279901 [PubMed - indexed for MEDLINE]Related articles

Virodynamic predictors of response to pegylated interferon and lamivudine combination treatment of hepatitis B e antigen-positive chronic hepatitis B.

Mihm U, Chan HL, Zeuzem S, Chim AM, Hui AY, Wong VW, Sung JJ, Herrmann E.

Antivir Ther. 2008;13(8):1029-37.PMID: 19195328 [PubMed - indexed for MEDLINE]Related articles

Adefovir and lamivudine in combination compared with adefovir monotherapy in HBeAg-negative adults with chronic hepatitis B virus infection and clinical or virologic resistance to lamivudine: a retrospective, multicenter, nonrandomized, open-label study.

Pellicelli AM, Barbaro G, Francavilla R, Romano M, Barbarini G, Mazzoni E, Mecenate F, Paffetti A, Barlattani A, Struglia C, Villani R, Nauri L, Nosotti L, Armignacco O, Ferri F, Camporiondo MP, Soccorsi F; Club Epatologi Ospedalieri (CLEO) Group.

Clin Ther. 2008 Feb;30(2):317-23.PMID: 18343270 [PubMed - indexed for MEDLINE]Related articles

Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation.

Shepherd J, Jones J, Takeda A, Davidson P, Price A.

Health Technol Assess. 2006 Aug;10(28):iii-iv, xi-xiv, 1-183. Review.PMID: 16904047 [PubMed - indexed for MEDLINE]Related articlesFree article

Lamivudine and 24 weeks of lamivudine/interferon combination therapy for hepatitis B e antigen-positive chronic hepatitis B in interferon nonresponders.

Schiff ER, Dienstag JL, Karayalcin S, Grimm IS, Perrillo RP, Husa P, de Man RA, Goodman Z, Condreay LD, Crowther LM, Woessner MA, McPhillips PJ, Brown NA; International Lamivudine Investigator Group.

J Hepatol. 2003 Jun;38(6):818-26.PMID: 12763376 [PubMed - indexed for MEDLINE]Related articles

A partially overlapping treatment course with lamivudine and interferon in hepatitis B e antigen-negative chronic hepatitis B.

Manesis EK, Papatheodoridis GV, Hadziyannis SJ.

Aliment Pharmacol Ther. 2006 Jan 1;23(1):99-106.PMID: 16393286 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of chronic hepatitis B with the sequential administration of interferon and lamivudine.

Hasan F, al-Khaldi J, Asker H, Varghese R, Siddique I, al-Shammali M, al-Kalaoui M, al-Nakib B.

Hepatogastroenterology. 2003 Nov-Dec;50(54):2040-2.PMID: 14696461 [PubMed - indexed for MEDLINE]Related articles

Efficacy of granulocyte-macrophage colony-stimulating factor or lamivudine combination with recombinant interferon in non-responders to interferon in hepatitis B virus-related chronic liver disease patients.

Guptan RC, Thakur V, Kazim SN, Sarin SK.

J Gastroenterol Hepatol. 2002 Jul;17(7):765-71.PMID: 12121506 [PubMed - indexed for MEDLINE]Related articles

Long-term follow-up of peginterferon and lamivudine combination treatment in HBeAg-positive chronic hepatitis B.

Chan HL, Hui AY, Wong VW, Chim AM, Wong ML, Sung JJ.

Hepatology. 2005 Jun;41(6):1357-64.PMID: 15880608 [PubMed - indexed for MEDLINE]Related articles

Modelling of early viral kinetics and pegylated interferon-alpha2b pharmacokinetics in patients with HBeag-positive chronic hepatitis B.

ter Borg MJ, Hansen BE, Herrmann E, Zeuzem S, Cakaloglu Y, Karayalcin S, Flisiak R, van' t Veen A, de Man RA, Schalm SW, Janssen HL, Haagmans BL; HBV 99-01 Study Group.

Antivir Ther. 2007;12(8):1285-94.PMID: 18240868 [PubMed - indexed for MEDLINE]Related articles

Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial.

Schalm SW, Heathcote J, Cianciara J, Farrell G, Sherman M, Willems B, Dhillon A, Moorat A, Barber J, Gray DF.

Gut. 2000 Apr;46(4):562-8.PMID: 10716688 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of pegylated interferon-alpha on the treatment of lamivudine resistant chronic HBeAg positive hepatitis B virus infection.

Leemans WF, Flink HJ, Janssen HL, Niesters HG, Schalm SW, de Man RA.

J Hepatol. 2006 Mar;44(3):507-11. Epub 2006 Jan 19.PMID: 16457904 [PubMed - indexed for MEDLINE]Related articles

Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial.

Chan HL, Heathcote EJ, Marcellin P, Lai CL, Cho M, Moon YM, Chao YC, Myers RP, Minuk GY, Jeffers L, Sievert W, Bzowej N, Harb G, Kaiser R, Qiao XJ, Brown NA; 018 Study Group.

Ann Intern Med. 2007 Dec 4;147(11):745-54. Epub 2007 Oct 1.PMID: 17909201 [PubMed - indexed for MEDLINE]Related articlesFree article

Peg-interferon improves liver histology in patients with HBeAg-positive chronic hepatitis B: no additional benefit of combination with lamivudine.

van Zonneveld M, Zondervan PE, Cakaloglu Y, Simon C, Akarca US, So TM, Flink HJ, de Man RA, Schalm SW, Janssen HL; HBV 99-01 Study Group.

Liver Int. 2006 May;26(4):399-405.PMID: 16629642 [PubMed - indexed for MEDLINE]Related articles