PubMed

Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury.

Yue TL, Bao W, Gu JL, Cui J, Tao L, Ma XL, Ohlstein EH, Jucker BM.

Diabetes. 2005 Feb;54(2):554-62.PMID: 15677515 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.

Upton R, Widdowson PS, Ishii S, Tanaka H, Williams G.

Br J Pharmacol. 1998 Dec;125(8):1708-14.PMID: 9886762 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.

Bulhak AA, Jung C, Ostenson CG, Lundberg JO, Sjöquist PO, Pernow J.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H719-27. Epub 2009 Jan 16.PMID: 19151258 [PubMed - indexed for MEDLINE]Related articles

Long-term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism.

Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, Yu QJ, Guo WY, Wang HC, Gao F.

Apoptosis. 2007 Sep;12(9):1579-88.PMID: 17505785 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone protects against ischemia/reperfusion-induced leukocyte adhesion in the zucker diabetic fatty rat.

Johns DG, Ao Z, Eybye M, Olzinski A, Costell M, Gruver S, Smith SA, Douglas SA, Macphee CH.

J Pharmacol Exp Ther. 2005 Dec;315(3):1020-7. Epub 2005 Aug 25.PMID: 16123307 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart.

Sidell RJ, Cole MA, Draper NJ, Desrois M, Buckingham RE, Clarke K.

Diabetes. 2002 Apr;51(4):1110-7.PMID: 11916933 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of peroxisome proliferator activator receptor-alpha and gamma ligands on intimal hyperplasia after balloon catheter-induced vascular injury in Zucker rats.

Desouza CV, Murthy SN, Diez J, Dunne B, Matta AS, Fonseca VA, McNamara DB.

J Cardiovasc Pharmacol Ther. 2003 Dec;8(4):297-305.PMID: 14740079 [PubMed - indexed for MEDLINE]Related articles

In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.

Yue TL, Nerurkar SS, Bao W, Jucker BM, Sarov-Blat L, Steplewski K, Ohlstein EH, Willette RN.

J Pharmacol Exp Ther. 2008 May;325(2):466-74. Epub 2008 Feb 20.PMID: 18287212 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement inhibition reduces injury in the type 2 diabetic heart following ischemia and reperfusion.

La Bonte LR, Davis-Gorman G, Stahl GL, McDonagh PF.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1282-90. Epub 2008 Jan 4.PMID: 18178726 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.

Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt MV, Demuth HU, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2005 Mar;7(2):170-81.PMID: 15715890 [PubMed - indexed for MEDLINE]Related articles

Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat.

Taniguchi Y, Ooie T, Takahashi N, Shinohara T, Nakagawa M, Yonemochi H, Hara M, Yoshimatsu H, Saikawa T.

Diabetes. 2006 Aug;55(8):2371-8.PMID: 16873703 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds.

Wasan KM, Risovic V, Yuen VG, McNeill JH.

J Trace Elem Med Biol. 2006;19(4):251-8. Epub 2005 Dec 13.PMID: 16443173 [PubMed - indexed for MEDLINE]Related articles

Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression.

Bhuiyan MS, Shibuya M, Shioda N, Moriguchi S, Kasahara J, Iwabuchi Y, Fukunaga K.

Eur J Pharmacol. 2007 Oct 1;571(2-3):180-8. Epub 2007 Jun 9.PMID: 17658509 [PubMed - indexed for MEDLINE]Related articles

v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats.

Maier VH, Melvin DR, Lister CA, Chapman H, Gould GW, Murphy GJ.

Diabetes. 2000 Apr;49(4):618-25.PMID: 10871200 [PubMed - indexed for MEDLINE]Related articlesFree article

[Effects of glucose-insulin-potassium cocktail on cardiac myocyte death and post-ischemic recovery cardiac functional recovery: the critical role of insulin]

Gao F, Shi DW, Wang XM, Dong L, Wang YM, Ma XL.

Zhonghua Nei Ke Za Zhi. 2003 Mar;42(3):148-52. Chinese. PMID: 12816693 [PubMed - indexed for MEDLINE]Related articles

Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.

Brand CL, Sturis J, Gotfredsen CF, Fleckner J, Fledelius C, Hansen BF, Andersen B, Ye JM, Sauerberg P, Wassermann K.

Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E841-54. Epub 2002 Dec 10.PMID: 12475752 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologically tolerable insulin reduces myocardial injury and improves cardiac functional recovery in myocardial ischemic/reperfused dogs.

Zhang HX, Zang YM, Huo JH, Liang SJ, Zhang HF, Wang YM, Fan Q, Guo WY, Wang HC, Gao F.

J Cardiovasc Pharmacol. 2006 Dec;48(6):306-13.PMID: 17204910 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone.

Cai XJ, Lister CA, Buckingham RE, Pickavance L, Wilding J, Arch JR, Wilson S, Williams G.

Brain Res Mol Brain Res. 2000 Apr 14;77(1):131-7.PMID: 10814839 [PubMed - indexed for MEDLINE]Related articles

Phosphatidylinositol 3-kinase-dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced diabetic heart.

Shinohara T, Takahashi N, Ooie T, Hara M, Shigematsu S, Nakagawa M, Yonemochi H, Saikawa T, Yoshimatsu H.

Diabetes. 2006 May;55(5):1307-15.PMID: 16644687 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.

Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE.

Diabetes. 2001 May;50(5):1021-9.PMID: 11334404 [PubMed - indexed for MEDLINE]Related articlesFree article