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    Results: 1 to 20 of 406

    1.

    Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

    Takahashi A, Motomura K, Kato T, Yoshikawa T, Nakagawa Y, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N, Shimano H.

    Diabetes. 2005 Feb;54(2):492-9.PMID: 15677507 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

    Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M, Kadowaki T.

    Endocrinology. 2004 Aug;145(8):3566-77. Epub 2004 Apr 1.PMID: 15059954 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism.

    Shimano H.

    Vitam Horm. 2002;65:167-94. Review.PMID: 12481547 [PubMed - indexed for MEDLINE]Related articles

    4.

    Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.

    Amemiya-Kudo M, Oka J, Ide T, Matsuzaka T, Sone H, Yoshikawa T, Yahagi N, Ishibashi S, Osuga J, Yamada N, Murase T, Shimano H.

    J Biol Chem. 2005 Oct 14;280(41):34577-89. Epub 2005 Jul 29.PMID: 16055439 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

    Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

    J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.PMID: 14985368 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction.

    Shimano H, Amemiya-Kudo M, Takahashi A, Kato T, Ishikawa M, Yamada N.

    Diabetes Obes Metab. 2007 Nov;9 Suppl 2:133-9.PMID: 17919187 [PubMed - indexed for MEDLINE]Related articles

    7.

    Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.

    Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N.

    Diabetes. 2008 Sep;57(9):2382-92. Epub 2008 May 5.PMID: 18458149 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

    Iwasaki Y, Iwasaki H, Yatoh S, Ishikawa M, Kato T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Suzuki H, Yamada N, Shimano H.

    Biochem Biophys Res Commun. 2009 Jan 16;378(3):545-50. Epub 2008 Dec 3.PMID: 19056350 [PubMed - indexed for MEDLINE]Related articles

    9.

    Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes.

    Foretz M, Guichard C, Ferré P, Foufelle F.

    Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12737-42.PMID: 10535992 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction.

    Wang H, Maechler P, Antinozzi PA, Herrero L, Hagenfeldt-Johansson KA, Bjorklund A, Wollheim CB.

    J Biol Chem. 2003 May 9;278(19):16622-9. Epub 2003 Feb 24.PMID: 12600983 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.

    Takahashi A, Shimano H, Nakagawa Y, Yamamoto T, Motomura K, Matsuzaka T, Sone H, Suzuki H, Toyoshima H, Yamada N.

    Biochim Biophys Acta. 2005 Jun 10;1740(3):427-33. Epub 2004 Dec 16.PMID: 15949711 [PubMed - indexed for MEDLINE]Related articles

    12.

    Transcriptional regulation of human SREBP-1c (sterol-regulatory-element-binding protein-1c): a key regulator of lipogenesis.

    Tarling E, Salter A, Bennett A.

    Biochem Soc Trans. 2004 Feb;32(Pt 1):107-9.PMID: 14748724 [PubMed - indexed for MEDLINE]Related articles

    13.

    Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis [corrected].

    Nagata R, Nishio Y, Sekine O, Nagai Y, Maeno Y, Ugi S, Maegawa H, Kashiwagi A.

    J Biol Chem. 2004 Jul 9;279(28):29031-42. Epub 2004 May 3. Erratum in: J Biol Chem. 2004 Aug 27;279(35):37210. PMID: 15123654 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target.

    Le Lay S, Lefrère I, Trautwein C, Dugail I, Krief S.

    J Biol Chem. 2002 Sep 20;277(38):35625-34. Epub 2002 Jun 4.PMID: 12048207 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes.

    Shimano H.

    Prog Lipid Res. 2001 Nov;40(6):439-52. Review.PMID: 11591434 [PubMed - indexed for MEDLINE]Related articles

    16.

    Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

    Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS.

    Proc Natl Acad Sci U S A. 2001 May 22;98(11):6027-32.PMID: 11371634 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

    Diraison F, Parton L, Ferré P, Foufelle F, Briscoe CP, Leclerc I, Rutter GA.

    Biochem J. 2004 Mar 15;378(Pt 3):769-78.PMID: 14690455 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway.

    Guillet-Deniau I, Pichard AL, Koné A, Esnous C, Nieruchalski M, Girard J, Prip-Buus C.

    J Cell Sci. 2004 Apr 15;117(Pt 10):1937-44. Epub 2004 Mar 23.PMID: 15039461 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.

    Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga Ji J, Gotoda T, Ishibashi S, Yamada N.

    J Biol Chem. 2002 Jan 18;277(3):1705-11. Epub 2001 Nov 2.PMID: 11694526 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

    Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM.

    Endocrinology. 2006 Aug;147(8):3898-905. Epub 2006 Apr 27.PMID: 16644917 [PubMed - indexed for MEDLINE]Related articlesFree article

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