PubMed

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Herrero L, Rubí B, Sebastián D, Serra D, Asins G, Maechler P, Prentki M, Hegardt FG.

Diabetes. 2005 Feb;54(2):462-71.PMID: 15677504 [PubMed - indexed for MEDLINE]Related articlesFree article

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling.

Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD.

Diabetes. 1994 Jul;43(7):878-83.PMID: 8013751 [PubMed - indexed for MEDLINE]Related articles

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M.

Diabetes. 2004 Apr;53(4):1007-19.PMID: 15047616 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.

Mulder H, Lu D, Finley J 4th, An J, Cohen J, Antinozzi PA, McGarry JD, Newgard CB.

J Biol Chem. 2001 Mar 2;276(9):6479-84. Epub 2000 Dec 11.PMID: 11113153 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.

Antinozzi PA, Segall L, Prentki M, McGarry JD, Newgard CB.

J Biol Chem. 1998 Jun 26;273(26):16146-54.PMID: 9632669 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE.

J Biol Chem. 1992 Mar 25;267(9):5802-10.PMID: 1556096 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic beta-cell line.

Zhang S, Kim KH.

Cell Signal. 1998 Jan;10(1):35-42.PMID: 9502115 [PubMed - indexed for MEDLINE]Related articles

Increased L-CPT-1 activity and altered gene expression in pancreatic islets of malnourished adult rats: a possible relationship between elevated free fatty acid levels and impaired insulin secretion.

de Barros Reis MA, Arantes VC, Cunha DA, Latorraca MQ, Toyama MH, Carneiro EM, Boschero AC.

J Nutr Biochem. 2008 Feb;19(2):85-90. Epub 2007 May 24.PMID: 17531461 [PubMed - indexed for MEDLINE]Related articles

A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.

Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ.

Biochem J. 1998 Apr 15;331 ( Pt 2):553-61.PMID: 9531497 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M.

J Biol Chem. 1997 Jan 17;272(3):1659-64.PMID: 8999842 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids.

Akkaoui M, Cohen I, Esnous C, Lenoir V, Sournac M, Girard J, Prip-Buus C.

Biochem J. 2009 May 27;420(3):429-38.PMID: 19302064 [PubMed - indexed for MEDLINE]Related articles

Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.

Brun T, Roche E, Assimacopoulos-Jeannet F, Corkey BE, Kim KH, Prentki M.

Diabetes. 1996 Feb;45(2):190-8.PMID: 8549864 [PubMed - indexed for MEDLINE]Related articles

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.

Sebastián D, Herrero L, Serra D, Asins G, Hegardt FG.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E677-86. Epub 2006 Oct 24.PMID: 17062841 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperthyroidism facilitates cardiac fatty acid oxidation through altered regulation of cardiac carnitine palmitoyltransferase: studies in vivo and with cardiac myocytes.

Sugden MC, Priestman DA, Orfali KA, Holness MJ.

Horm Metab Res. 1999 May;31(5):300-6.PMID: 10422724 [PubMed - indexed for MEDLINE]Related articles

A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.

Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M.

J Biol Chem. 1989 Dec 25;264(36):21608-12.PMID: 2689441 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.

Rubí B, Antinozzi PA, Herrero L, Ishihara H, Asins G, Serra D, Wollheim CB, Maechler P, Hegardt FG.

Biochem J. 2002 May 15;364(Pt 1):219-26.PMID: 11988095 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle.

Alam N, Saggerson ED.

Biochem J. 1998 Aug 15;334 ( Pt 1):233-41.PMID: 9693125 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB.

J Biol Chem. 2007 Oct 26;282(43):31592-600. Epub 2007 Sep 6.PMID: 17823126 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 1999 Aug;48(8):1543-9.PMID: 10426371 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.

Green CD, Jump DB, Olson LK.

Endocrinology. 2009 Jun;150(6):2637-45. Epub 2009 Feb 19.PMID: 19228891 [PubMed - indexed for MEDLINE]Related articles