PubMed

Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output.

Camacho RC, Pencek RR, Lacy DB, James FD, Donahue EP, Wasserman DH.

Diabetes. 2005 Feb;54(2):373-82.PMID: 15677495 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin.

Camacho RC, Lacy DB, James FD, Donahue EP, Wasserman DH.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1039-43. Epub 2005 Jul 26.PMID: 16046457 [PubMed - indexed for MEDLINE]Related articlesFree article

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo.

Pencek RR, Shearer J, Camacho RC, James FD, Lacy DB, Fueger PT, Donahue EP, Snead W, Wasserman DH.

Diabetes. 2005 Feb;54(2):355-60.PMID: 15677492 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI.

Diabetes. 2001 May;50(5):1076-82.PMID: 11334411 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin.

Camacho RC, Pencek RR, Lacy DB, James FD, Wasserman DH.

Diabetes. 2004 Feb;53(2):285-93.PMID: 14747277 [PubMed - indexed for MEDLINE]Related articlesFree article

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.

Diabetes. 2002 Oct;51(10):2886-94. Erratum in: Diabetes 2003 Jan;52(1):223-4. PMID: 12351423 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.

Christopher M, Rantzau C, Chen ZP, Snow R, Kemp B, Alford FP.

Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1131-40. Epub 2006 Jun 13.PMID: 16772328 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of exercise, insulin, and hypoglycemia studied using euglycemic and hypoglycemic insulin clamps.

Zinker BA, Allison RG, Lacy DB, Wasserman DH.

Am J Physiol. 1997 Apr;272(4 Pt 1):E530-42.PMID: 9142871 [PubMed - indexed for MEDLINE]Related articles

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.

McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS.

Diabetes. 2004 Aug;53(8):1953-8.PMID: 15277372 [PubMed - indexed for MEDLINE]Related articlesFree article

A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake.

Galassetti P, Shiota M, Zinker BA, Wasserman DH, Cherrington AD.

Am J Physiol. 1998 Jul;275(1 Pt 1):E101-11.PMID: 9688880 [PubMed - indexed for MEDLINE]Related articlesFree article

Prior exercise and the response to insulin-induced hypoglycemia in the dog.

Koyama Y, Galassetti P, Coker RH, Pencek RR, Lacy DB, Davis SN, Wasserman DH.

Am J Physiol Endocrinol Metab. 2002 May;282(5):E1128-38.PMID: 11934679 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of insulin-stimulated glycogen synthesis by 5-aminoimidasole-4-carboxamide-1-beta-d-ribofuranoside-induced adenosine 5'-monophosphate-activated protein kinase activation: interactions with Akt, glycogen synthase kinase 3-3alpha/beta, and glycogen synthase in isolated rat soleus muscle.

Fediuc S, Gaidhu MP, Ceddia RB.

Endocrinology. 2006 Nov;147(11):5170-7. Epub 2006 Jul 27.PMID: 16873531 [PubMed - indexed for MEDLINE]Related articlesFree article

A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog.

Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD.

Diabetes. 1996 Nov;45(11):1594-604.PMID: 8866566 [PubMed - indexed for MEDLINE]Related articles

Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.

Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella MC, Cheng H, McNay EC, Sherwin RS, McCrimmon RJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1702-8. Epub 2009 Apr 8.PMID: 19357294 [PubMed - indexed for MEDLINE]Related articles

AMPK activation with AICAR provokes an acute fall in plasma [K+].

Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C126-35. Epub 2007 Nov 14.PMID: 18003746 [PubMed - indexed for MEDLINE]Related articlesFree article

Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs.

Pencek RR, Battram D, Shearer J, James FD, Lacy DB, Jabbour K, Williams PE, Graham TE, Wasserman DH.

J Nutr. 2004 Nov;134(11):3042-6.PMID: 15514273 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that carotid bodies play an important role in glucoregulation in vivo.

Koyama Y, Coker RH, Stone EE, Lacy DB, Jabbour K, Williams PE, Wasserman DH.

Diabetes. 2000 Sep;49(9):1434-42.PMID: 10969826 [PubMed - indexed for MEDLINE]Related articlesFree article

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.

Boon H, Bosselaar M, Praet SF, Blaak EE, Saris WH, Wagenmakers AJ, McGee SL, Tack CJ, Smits P, Hargreaves M, van Loon LJ.

Diabetologia. 2008 Oct;51(10):1893-900. Epub 2008 Aug 16.PMID: 18709353 [PubMed - indexed for MEDLINE]Related articles

Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism.

Rantzau C, Christopher M, Alford FP.

J Appl Physiol. 2008 Feb;104(2):363-70. Epub 2007 Nov 21.PMID: 18032581 [PubMed - indexed for MEDLINE]Related articlesFree article

Portal infusion of escitalopram enhances hepatic glucose disposal in conscious dogs.

An Z, Moore MC, Winnick JJ, Farmer B, Neal DW, Lautz M, Smith M, Rodewald T, Cherrington AD.

Eur J Pharmacol. 2009 Apr 1;607(1-3):251-7.PMID: 19326481 [PubMed - indexed for MEDLINE]Related articles