PubMed

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID.

Diabetes. 2005 Feb;54(2):367-72.PMID: 15677494 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren JF, Goldfine ID.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E746-9. Epub 2005 Nov 8.PMID: 16278247 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.

Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren JF.

Metabolism. 2002 Apr;51(4):465-70.PMID: 11912555 [PubMed - indexed for MEDLINE]Related articles

No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.

Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, Fukushima Y, Onishi Y, Ono H, Yazaki Y, Kikuchi M, Oka Y, Asano T.

Diabetes. 1999 Jul;48(7):1365-71.PMID: 10389840 [PubMed - indexed for MEDLINE]Related articlesFree article

Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.

Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E536-43. Epub 2006 Apr 18. Erratum in: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E370. PMID: 16621898 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.

Zhou HH, Chin CN, Wu M, Ni W, Quan S, Liu F, Dallas-Yang Q, Ellsworth K, Ho T, Zhang A, Natasha T, Li J, Chapman K, Strohl W, Li C, Wang IM, Berger J, An Z, Zhang BB, Jiang G.

Eur J Pharmacol. 2009 Aug 15;616(1-3):346-52. Epub 2009 Jul 3.PMID: 19577557 [PubMed - indexed for MEDLINE]Related articles

A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities.

Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, Spampinato D, Di Paola R, Cisternino C, Tassi V, Vigneri R, Pizzuti A, Trischitta V.

Diabetes. 2001 Aug;50(8):1952-5.PMID: 11473061 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane glycoprotein PC-1 and insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Frittitta L, Trischitta V, Dohm GL.

Mol Cell Biochem. 1998 May;182(1-2):177-84. Review.PMID: 9609127 [PubMed - indexed for MEDLINE]Related articles

Effects of resistin expression on glucose metabolism and hepatic insulin resistance.

Li FP, He J, Li ZZ, Luo ZF, Yan L, Li Y.

Endocrine. 2009 Apr;35(2):243-51. Epub 2009 Jan 31.PMID: 19184634 [PubMed - indexed for MEDLINE]Related articles

Plasma cell membrane glycoprotein 1 (PC-1): a marker of insulin resistance in obesity, uremia and diabetes mellitus.

Stefanović V, Antić S.

Clin Lab. 2004;50(5-6):271-8. Review.PMID: 15209435 [PubMed - indexed for MEDLINE]Related articles

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

Maddux BA, Goldfine ID.

Diabetes. 2000 Jan;49(1):13-9.PMID: 10615944 [PubMed - indexed for MEDLINE]Related articlesFree article

PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity.

Frittitta L, Youngren J, Vigneri R, Maddux BA, Trischitta V, Goldfine ID.

Diabetologia. 1996 Oct;39(10):1190-5.PMID: 8897006 [PubMed - indexed for MEDLINE]Related articles

Lymphocyte PC-1 activity in patients on maintenance haemodialysis treated with human erythropoietin and 1-alpha-D3.

Stefanovic V, Djordjevic V, Ivic M, Mitic-Zlatkovic M, Vlahovic P.

Ann Clin Biochem. 2005 Jan;42(Pt 1):55-60.PMID: 15802034 [PubMed - indexed for MEDLINE]Related articles

Role of PC-1 in the etiology of insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L.

Ann N Y Acad Sci. 1999 Nov 18;892:204-22. Review.PMID: 10842664 [PubMed - indexed for MEDLINE]Related articles

Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site.

Kumakura S, Maddux BA, Sung CK.

J Cell Biochem. 1998 Mar 1;68(3):366-77.PMID: 9518262 [PubMed - indexed for MEDLINE]Related articles

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

Endocr Rev. 2008 Feb;29(1):62-75. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117. PMID: 18199690 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

Frittitta L, Spampinato D, Solini A, Nosadini R, Goldfine ID, Vigneri R, Trischitta V.

Diabetes. 1998 Jul;47(7):1095-100.PMID: 9648833 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistance.

Whitehead JP, Humphreys PJ, Dib K, Goding JW, O'Rahilly S.

Clin Endocrinol (Oxf). 1997 Jul;47(1):65-70.PMID: 9302374 [PubMed - indexed for MEDLINE]Related articles

High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells.

Frittitta L, Sbraccia P, Costanzo BV, Tassi V, D'Adamo M, Spampinato D, Ercolino T, Purrello F, Tamburrano G, Vigneri R, Trischitta V.

Diabetes Metab Res Rev. 2000 Jan-Feb;16(1):26-32.PMID: 10707036 [PubMed - indexed for MEDLINE]Related articles

Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance.

Teno S, Kanno H, Oga S, Kumakura S, Kanamuro R, Iwamoto Y.

Diabetes Res Clin Pract. 1999 Aug;45(1):25-30.PMID: 10499882 [PubMed - indexed for MEDLINE]Related articles