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    Results: 1 to 20 of 129

    1.

    Development of a long-acting insulin analog using albumin fusion technology.

    Duttaroy A, Kanakaraj P, Osborn BL, Schneider H, Pickeral OK, Chen C, Zhang G, Kaithamana S, Singh M, Schulingkamp R, Crossan D, Bock J, Kaufman TE, Reavey P, Carey-Barber M, Krishnan SR, Garcia A, Murphy K, Siskind JK, McLean MA, Cheng S, Ruben S, Birse CE, Blondel O.

    Diabetes. 2005 Jan;54(1):251-8.PMID: 15616036 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.

    Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang L, Strifler BA, Li S, Shang J, Beals JM, Mayer JP, DiMarchi RD.

    Peptides. 2007 Apr;28(4):935-48. Epub 2007 Jan 25.PMID: 17328992 [PubMed - indexed for MEDLINE]Related articles

    4.

    Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.

    Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, Yoon JW, Jun HS.

    Diabetes. 2007 Jun;56(6):1671-9. Epub 2007 Mar 16.PMID: 17369525 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes.

    Lagathu C, Yvan-Charvet L, Bastard JP, Maachi M, Quignard-Boulangé A, Capeau J, Caron M.

    Diabetologia. 2006 Sep;49(9):2162-73. Epub 2006 Jul 25.PMID: 16865359 [PubMed - indexed for MEDLINE]Related articles

    6.

    The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.

    Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B.

    J Biol Chem. 2006 Apr 21;281(16):11039-49. Epub 2006 Jan 30.PMID: 16446356 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Effects of fatty acid regulation on visfatin gene expression in adipocytes.

    Wen Y, Wang HW, Wu J, Lu HL, Hu XF, Cianflone K.

    Chin Med J (Engl). 2006 Oct 20;119(20):1701-8.PMID: 17097017 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Hepatic expression of the human insulin gene reduces glucose levels in vivo in diabetic mice model.

    Ajamian F, Titok T, Suhorada E, Ruban T, Reeben M.

    Diabetes Metab. 2003 Sep;29(4 Pt 1):424-9.PMID: 14526271 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Synthesis and evaluation of insulin-human serum albumin conjugates.

    Thibaudeau K, Léger R, Huang X, Robitaille M, Quraishi O, Soucy C, Bousquet-Gagnon N, van Wyk P, Paradis V, Castaigne JP, Bridon D.

    Bioconjug Chem. 2005 Jul-Aug;16(4):1000-8.PMID: 16029043 [PubMed - indexed for MEDLINE]Related articles

    10.

    Preparation and characterization of a novel exendin-4 human serum albumin fusion protein expressed in Pichia pastoris.

    Huang YS, Chen Z, Chen YQ, Ma GC, Shan JF, Liu W, Zhou LF.

    J Pept Sci. 2008 May;14(5):588-95.PMID: 17994612 [PubMed - indexed for MEDLINE]Related articles

    11.

    Insulin analog preparations and their use in children and adolescents with type 1 diabetes mellitus.

    Miles HL, Acerini CL.

    Paediatr Drugs. 2008;10(3):163-76. Review.PMID: 18454569 [PubMed - indexed for MEDLINE]Related articles

    12.

    An IFN-beta-albumin fusion protein that displays improved pharmacokinetic and pharmacodynamic properties in nonhuman primates.

    Sung C, Nardelli B, LaFleur DW, Blatter E, Corcoran M, Olsen HS, Birse CE, Pickeral OK, Zhang J, Shah D, Moody G, Gentz S, Beebe L, Moore PA.

    J Interferon Cytokine Res. 2003 Jan;23(1):25-36.PMID: 12639296 [PubMed - indexed for MEDLINE]Related articles

    13.

    Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice.

    Han GC, Ko SK, Sung JH, Chung SH.

    J Agric Food Chem. 2007 Dec 26;55(26):10641-8. Epub 2007 Nov 23.PMID: 18034458 [PubMed - indexed for MEDLINE]Related articles

    14.

    Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

    Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K.

    FEBS Lett. 2008 Mar 5;582(5):573-8. Epub 2008 Jan 31.PMID: 18242188 [PubMed - indexed for MEDLINE]Related articles

    15.
    16.

    The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo.

    Li YY, Wu HS, Tang L, Feng CR, Yu JH, Li Y, Yang YS, Yang B, He QJ.

    Pharmacol Res. 2007 Oct;56(4):335-43. Epub 2007 Aug 9.PMID: 17889553 [PubMed - indexed for MEDLINE]Related articles

    17.

    Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo.

    Kim HS, Ali O, Shim M, Lee KW, Vuguin P, Muzumdar R, Barzilai N, Cohen P.

    Pediatr Res. 2007 Feb;61(2):159-64.PMID: 17237715 [PubMed - indexed for MEDLINE]Related articles

    18.

    Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes.

    Renström F, Burén J, Svensson M, Eriksson JW.

    Metabolism. 2007 Feb;56(2):190-8.PMID: 17224332 [PubMed - indexed for MEDLINE]Related articles

    19.

    [Treatment of type 1 diabetes by transplantation of bone-derived mesenchymal stem cells expressing human insulin gene: experiment with mice]

    Xu J, Zhu MY, Lu YH, Lu Y, Wang ZW.

    Zhonghua Yi Xue Za Zhi. 2007 Sep 25;87(36):2557-60. Chinese. PMID: 18067833 [PubMed - indexed for MEDLINE]Related articles

    20.

    Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin.

    Wada T, Azegami M, Sugiyama M, Tsuneki H, Sasaoka T.

    Diabetes Res Clin Pract. 2008 Sep;81(3):269-77. Epub 2008 Jun 27.PMID: 18585815 [PubMed - indexed for MEDLINE]Related articles

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