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Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

Bohlooly-Y M, Olsson B, Bruder CE, Lindén D, Sjögren K, Bjursell M, Egecioglu E, Svensson L, Brodin P, Waterton JC, Isaksson OG, Sundler F, Ahrén B, Ohlsson C, Oscarsson J, Törnell J.

Diabetes. 2005 Jan;54(1):51-62. Erratum in: Diabetes. 2005 Apr;54(4):1249. Bohlooly, Mohammad [corrected to Bohlooly-Y, Mohammad]. PMID: 15616010 [PubMed - indexed for MEDLINE]Related articlesFree article

Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.

Oberbauer AM, Stern JS, Johnson PR, Horwitz BA, German JB, Phinney SD, Beermann DH, Pomp D, Murray JD.

Growth Dev Aging. 1997 Fall-Winter;61(3-4):169-79.PMID: 9546108 [PubMed - indexed for MEDLINE]Related articles

Bovine growth hormone transgenic mice are resistant to diet-induced obesity but develop hyperphagia, dyslipidemia, and diabetes on a high-fat diet.

Olsson B, Bohlooly-Y M, Fitzgerald SM, Frick F, Ljungberg A, Ahrén B, Törnell J, Bergström G, Oscarsson J.

Endocrinology. 2005 Feb;146(2):920-30. Epub 2004 Nov 11.PMID: 15539551 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity.

Lin EJ, Sainsbury A, Lee NJ, Boey D, Couzens M, Enriquez R, Slack K, Bland R, During MJ, Herzog H.

Endocrinology. 2006 Nov;147(11):5094-101. Epub 2006 Jul 27.PMID: 16873543 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice.

Clerc P, Coll Constans MG, Lulka H, Broussaud S, Guigné C, Leung-Theung-Long S, Perrin C, Knauf C, Carpéné C, Pénicaud L, Seva C, Burcelin R, Valet P, Fourmy D, Dufresne M.

Endocrinology. 2007 Mar;148(3):1039-49. Epub 2006 Nov 22.PMID: 17122076 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.PMID: 17363744 [PubMed - indexed for MEDLINE]Related articlesFree article

A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I.

Sjögren K, Jansson JO, Isaksson OG, Ohlsson C.

Minerva Endocrinol. 2002 Dec;27(4):299-311. Review.PMID: 12511852 [PubMed - indexed for MEDLINE]Related articles

Development of obesity following inactivation of a growth hormone transgene in mice.

Pomp D, Oberbauer AM, Murray JD.

Transgenic Res. 1996 Jan;5(1):13-23.PMID: 8589737 [PubMed - indexed for MEDLINE]Related articles

Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.

Lall S, Tung LY, Ohlsson C, Jansson JO, Dickson SL.

Biochem Biophys Res Commun. 2001 Jan 12;280(1):132-8.PMID: 11162489 [PubMed - indexed for MEDLINE]Related articles

Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice.

Bartke A, Chandrashekar V, Turyn D, Steger RW, Debeljuk L, Winters TA, Mattison JA, Danilovich NA, Croson W, Wernsing DR, Kopchick JJ.

Proc Soc Exp Biol Med. 1999 Nov;222(2):113-23. Review.PMID: 10564535 [PubMed - indexed for MEDLINE]Related articlesFree article

Alcohol suppresses insulin-like growth factor-1 gene expression in prepubertal transgenic female mice overexpressing the bovine growth hormone gene.

Srivastava VK, Dearth RK, Hiney JK, Chandrashekar V, Mattison JA, Bartke A, Dees WL.

Alcohol Clin Exp Res. 2002 Nov;26(11):1697-702.PMID: 12436059 [PubMed - indexed for MEDLINE]Related articles

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.

Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW.

Nat Med. 2006 Jun;12(6):650-6. Epub 2006 May 28.PMID: 16732281 [PubMed - indexed for MEDLINE]Related articles

Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice.

Egecioglu E, Bjursell M, Ljungberg A, Dickson SL, Kopchick JJ, Bergström G, Svensson L, Oscarsson J, Törnell J, Bohlooly-Y M.

Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E317-25. Epub 2005 Sep 20.PMID: 16174655 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function.

Luque RM, Kineman RD.

Endocrinology. 2006 Jun;147(6):2754-63. Epub 2006 Mar 2.PMID: 16513828 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of hyperinsulinemia on hepatic insulin receptor concentration and autophosphorylation in the presence of high growth hormone levels in transgenic mice overexpressing growth hormone gene.

Dominici FP, Balbis A, Bartke A, Turyn D.

J Endocrinol. 1998 Oct;159(1):15-25.PMID: 9795337 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1.

Katterle Y, Keipert S, Hof J, Klaus S.

Physiol Genomics. 2008 Feb 19;32(3):352-9. Epub 2007 Nov 27.PMID: 18042832 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L.

J Clin Invest. 2007 Feb;117(2):397-406. Epub 2007 Jan 18.PMID: 17235396 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of brain-region-specific forms of obesity by agouti.

Kas MJ, Tiesjema B, van Dijk G, Garner KM, Barsh GS, ter Brake O, Verhaagen J, Adan RA.

J Neurosci. 2004 Nov 10;24(45):10176-81.PMID: 15537888 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparing adiposity profiles in three mouse models with altered GH signaling.

Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ.

Growth Horm IGF Res. 2004 Aug;14(4):309-18.PMID: 15231300 [PubMed - indexed for MEDLINE]Related articles

Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons.

Lall S, Balthasar N, Carmignac D, Magoulas C, Sesay A, Houston P, Mathers K, Robinson I.

Endocrinology. 2004 Apr;145(4):1602-11. Epub 2003 Dec 30.PMID: 14701677 [PubMed - indexed for MEDLINE]Related articlesFree article