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The Janus kinases (Jaks).
Yamaoka K, Saharinen P, Pesu M, Holt VE 3rd, Silvennoinen O, O'Shea JJ.
Genome Biol. 2004;5(12):253. Epub 2004 Nov 30. Review.
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CXCL12 signaling is independent of Jak2 and Jak3.
Moriguchi M, Hissong BD, Gadina M, Yamaoka K, Tiffany HL, Murphy PM, Candotti F, O'Shea JJ.
J Biol Chem. 2005 Apr 29;280(17):17408-14. Epub 2004 Dec 20.
Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
Liu KD, Gaffen SL, Goldsmith MA, Greene WC.
Curr Biol. 1997 Nov 1;7(11):817-26.
Cross-regulation of JAK and Src kinases.
Ingley E, Klinken SP.
Growth Factors. 2006 Mar;24(1):89-95. Review.
Inhibition of the janus kinase family increases extracellular signal-regulated kinase 1/2 phosphorylation and causes endoreduplication.
Reiterer G, Yen A.
Cancer Res. 2006 Sep 15;66(18):9083-9.
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130.
Hilkens CM, Is'harc H, Lillemeier BF, Strobl B, Bates PA, Behrmann I, Kerr IM.
FEBS Lett. 2001 Sep 7;505(1):87-91.
JAK protein kinase inhibitors.
Thompson JE.
Drug News Perspect. 2005 Jun;18(5):305-10. Review.
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.
Vainchenker W, Dusa A, Constantinescu SN.
Semin Cell Dev Biol. 2008 Aug;19(4):385-93. Epub 2008 Jul 17. Review.
Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling.
He K, Wang X, Jiang J, Guan R, Bernstein KE, Sayeski PP, Frank SJ.
Mol Endocrinol. 2003 Nov;17(11):2211-27. Epub 2003 Aug 14.
Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
Cacalano NA, Migone TS, Bazan F, Hanson EP, Chen M, Candotti F, O'Shea JJ, Johnston JA.
EMBO J. 1999 Mar 15;18(6):1549-58.
Signaling through the hematopoietic cytokine receptors.
Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O.
Annu Rev Immunol. 1995;13:369-98. Review.
Janus kinases and their role in growth and disease.
Aringer M, Cheng A, Nelson JW, Chen M, Sudarshan C, Zhou YJ, O'Shea JJ.
Life Sci. 1999;64(24):2173-86. Review.
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
Staerk J, Kallin A, Demoulin JB, Vainchenker W, Constantinescu SN.
J Biol Chem. 2005 Dec 23;280(51):41893-9. Epub 2005 Oct 19.
Jak family of kinases in cancer.
Verma A, Kambhampati S, Parmar S, Platanias LC.
Cancer Metastasis Rev. 2003 Dec;22(4):423-34. Review.
Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency.
O'Shea JJ, Notarangelo LD, Johnston JA, Candotti F.
J Clin Immunol. 1997 Nov;17(6):431-47. Review.
Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.
Giordanetto F, Kroemer RT.
Protein Eng. 2002 Sep;15(9):727-37.
Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules.
Steindler C, Li Z, Algarté M, Alcover A, Libri V, Ragimbeau J, Pellegrini S.
J Biol Chem. 2004 Oct 8;279(41):43168-77. Epub 2004 Jul 23.
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.
Behrmann I, Smyczek T, Heinrich PC, Schmitz-Van de Leur H, Komyod W, Giese B, Müller-Newen G, Haan S, Haan C.
J Biol Chem. 2004 Aug 20;279(34):35486-93. Epub 2004 May 3.
Jaks and cytokine receptors--an intimate relationship.
Haan C, Kreis S, Margue C, Behrmann I.
Biochem Pharmacol. 2006 Nov 30;72(11):1538-46. Epub 2006 Apr 27. Review.
Growth hormone receptor interaction with Jak proteins differs between tissues.
Hellgren G, Albertsson-Wikland K, Billig H, Carlsson LM, Carlsson B.
J Interferon Cytokine Res. 2001 Feb;21(2):75-83.
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