PubMed

Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.

Renzoni EA, Abraham DJ, Howat S, Shi-Wen X, Sestini P, Bou-Gharios G, Wells AU, Veeraraghavan S, Nicholson AG, Denton CP, Leask A, Pearson JD, Black CM, Welsh KI, du Bois RM.

Respir Res. 2004 Nov 30;5:24.PMID: 15571627 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.

Shi-wen X, Kennedy L, Renzoni EA, Bou-Gharios G, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A.

Arthritis Rheum. 2007 Dec;56(12):4189-94.PMID: 18050250 [PubMed - indexed for MEDLINE]Related articlesFree article

The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis.

Königshoff M, Wilhelm A, Jahn A, Sedding D, Amarie OV, Eul B, Seeger W, Fink L, Günther A, Eickelberg O, Rose F.

Am J Respir Cell Mol Biol. 2007 Dec;37(6):640-50. Epub 2007 Jul 13.PMID: 17630322 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.

Denton CP, Zheng B, Evans LA, Shi-wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B.

J Biol Chem. 2003 Jul 4;278(27):25109-19. Epub 2003 Apr 21.PMID: 12707256 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.

Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC, Varga J.

Arthritis Rheum. 2004 Dec;50(12):4008-21.PMID: 15593186 [PubMed - indexed for MEDLINE]Related articlesFree article

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching.

Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA.

Am J Pathol. 2003 Feb;162(2):533-46.PMID: 12547711 [PubMed - indexed for MEDLINE]Related articlesFree article

RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis.

Watts KL, Cottrell E, Hoban PR, Spiteri MA.

Respir Res. 2006 Jun 15;7:88.PMID: 16776827 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

Kapoun AM, Gaspar NJ, Wang Y, Damm D, Liu YW, O'young G, Quon D, Lam A, Munson K, Tran TT, Ma JY, Murphy A, Dugar S, Chakravarty S, Protter AA, Wen FQ, Liu X, Rennard SI, Higgins LS.

Mol Pharmacol. 2006 Aug;70(2):518-31. Epub 2006 May 17.PMID: 16707625 [PubMed - indexed for MEDLINE]Related articlesFree article

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55.PMID: 19565505 [PubMed - indexed for MEDLINE]Related articles

Bone morphogenetic proteins.

Chen D, Zhao M, Mundy GR.

Growth Factors. 2004 Dec;22(4):233-41. Review.PMID: 15621726 [PubMed - indexed for MEDLINE]Related articles

Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.

Sonnylal S, Denton CP, Zheng B, Keene DR, He R, Adams HP, Vanpelt CS, Geng YJ, Deng JM, Behringer RR, de Crombrugghe B.

Arthritis Rheum. 2007 Jan;56(1):334-44.PMID: 17195237 [PubMed - indexed for MEDLINE]Related articlesFree article

Silica and its antagonistic effects on transforming growth factor-beta in lung fibroblast extracellular matrix production.

Baroni T, Bodo M, D'Alessandro A, Conte C, Calvitti M, Muzi G, Lumare A, Bellocchio S, Abbritti G.

J Investig Med. 2001 Mar;49(2):146-56.PMID: 11288755 [PubMed - indexed for MEDLINE]Related articles

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta.

Bhattacharyya S, Ghosh AK, Pannu J, Mori Y, Takagawa S, Chen G, Trojanowska M, Gilliam AC, Varga J.

Arthritis Rheum. 2005 Apr;52(4):1248-58.PMID: 15818659 [PubMed - indexed for MEDLINE]Related articlesFree article

Oligonucleotide microarray analysis of human lens epithelial cells: TGFbeta regulated gene expression.

Dawes LJ, Elliott RM, Reddan JR, Wormstone YM, Wormstone IM.

Mol Vis. 2007 Jul 17;13:1181-97.PMID: 17679943 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.

Martin MM, Buckenberger JA, Jiang J, Malana GE, Knoell DL, Feldman DS, Elton TS.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L790-9. Epub 2007 Jun 29.PMID: 17601799 [PubMed - indexed for MEDLINE]Related articlesFree article

Global expression analysis of the fibroblast transcriptional response to TGFbeta.

Gardner H, Strehlow D, Bradley L, Widom R, Farina A, de Fougerolles A, Peyman J, Koteliansky V, Korn JH.

Clin Exp Rheumatol. 2004 Jan-Feb;22(3 Suppl 33):S47-57.PMID: 15344598 [PubMed - indexed for MEDLINE]Related articles

The up-regulation of angiotensin II receptor type 1 and connective tissue growth factor are involved in high-glucose-induced fibronectin production by cultured human dermal fibroblasts.

Yevdokimova N, Podpryatov S.

J Dermatol Sci. 2007 Aug;47(2):127-39. Epub 2007 Mar 30.PMID: 17399955 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial-myofibroblast transdifferentiation.

Sebe A, Leivonen SK, Fintha A, Masszi A, Rosivall L, Kähäri VM, Mucsi I.

Nephrol Dial Transplant. 2008 May;23(5):1537-45. Epub 2008 Jan 11.PMID: 18192325 [PubMed - indexed for MEDLINE]Related articles

Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts.

Borowski A, Kuepper M, Horn U, Knüpfer U, Zissel G, Höhne K, Luttmann W, Krause S, Virchow JC Jr, Friedrich K.

Clin Exp Allergy. 2008 Apr;38(4):619-28. Epub 2008 Feb 11.PMID: 18266877 [PubMed - indexed for MEDLINE]Related articles

Role of integrin-mediated TGFbeta activation in the pathogenesis of pulmonary fibrosis.

Goodwin A, Jenkins G.

Biochem Soc Trans. 2009 Aug;37(Pt 4):849-54. Review.PMID: 19614606 [PubMed - indexed for MEDLINE]Related articles