PubMed

Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.

Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

Diabetes. 2004 Dec;53(12):3313-8.PMID: 15561965 [PubMed - indexed for MEDLINE]Related articlesFree article

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.

Florez JC, Sjögren M, Agapakis CM, Burtt NP, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L.

Diabetologia. 2007 Jun;50(6):1209-17. Epub 2007 Apr 19.PMID: 17443311 [PubMed - indexed for MEDLINE]Related articles

The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance.

Baroni MG, Arca M, Sentinelli F, Buzzetti R, Capici F, Lovari S, Vitale M, Romeo S, Di Mario U.

Diabetologia. 2001 Mar;44(3):367-72.PMID: 11317670 [PubMed - indexed for MEDLINE]Related articles

The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

Sesti G, Marini MA, Cardellini M, Sciacqua A, Frontoni S, Andreozzi F, Irace C, Lauro D, Gnasso A, Federici M, Perticone F, Lauro R.

Diabetes Care. 2004 Jun;27(6):1394-8.PMID: 15161794 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

Stefan N, Kovacs P, Stumvoll M, Hanson RL, Lehn-Stefan A, Permana PA, Baier LJ, Tataranni PA, Silver K, Bogardus C.

Diabetes. 2003 Jun;52(6):1544-50.PMID: 12765968 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI.

J Clin Endocrinol Metab. 2002 Sep;87(9):4297-300.PMID: 12213887 [PubMed - indexed for MEDLINE]Related articlesFree article

Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance.

Almind K, Frederiksen SK, Ahlgren MG, Urhammer S, Hansen T, Clausen JO, Pedersen O.

Diabetologia. 1998 Aug;41(8):969-74.PMID: 9726601 [PubMed - indexed for MEDLINE]Related articles

Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.

Hasstedt SJ, Ren QF, Teng K, Elbein SC.

J Clin Endocrinol Metab. 2001 Feb;86(2):536-41.PMID: 11158005 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.

Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L.

Diabetologia. 2005 Dec;48(12):2544-51. Epub 2005 Nov 17.PMID: 16320083 [PubMed - indexed for MEDLINE]Related articles

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.

McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium.

Diabetes. 2008 Apr;57(4):1125-30. Epub 2007 Dec 10.PMID: 18071025 [PubMed - indexed for MEDLINE]Related articlesFree article

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.

Koch M, Rett K, Volk A, Maerker E, Haist K, Deninger M, Renn W, Häring HU.

Exp Clin Endocrinol Diabetes. 1999;107(5):318-22.PMID: 10482045 [PubMed - indexed for MEDLINE]Related articles

Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people.

Gjesing AP, Andersen G, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Mol Genet Metab. 2008 May;94(1):90-7. Epub 2008 Jan 14.PMID: 18249022 [PubMed - indexed for MEDLINE]Related articles

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

Grarup N, Urhammer SA, Ek J, Albrechtsen A, Glümer C, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Diabetologia. 2006 Sep;49(9):2097-104. Epub 2006 Jul 25.PMID: 16865358 [PubMed - indexed for MEDLINE]Related articles

The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.

van Dam RM, Hoebee B, Seidell JC, Schaap MM, Blaak EE, Feskens EJ.

Diabet Med. 2004 Jul;21(7):752-8.PMID: 15209769 [PubMed - indexed for MEDLINE]Related articles

AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects.

Andersen G, Burgdorf KS, Sparsø T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Diabetes. 2008 May;57(5):1427-32. Epub 2008 Mar 3.PMID: 18316360 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus.

Celi FS, Negri C, Tanner K, Raben N, De Pablo F, Rovira A, Pallardo LF, Martin-Vaquero P, Stern MP, Mitchell BD, Shuldiner AR.

Diabetes Metab Res Rev. 2000 Sep-Oct;16(5):370-7.PMID: 11025561 [PubMed - indexed for MEDLINE]Related articles

Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.

Mammarella S, Romano F, Di Valerio A, Creati B, Esposito DL, Palmirotta R, Capani F, Vitullo P, Volpe G, Battista P, Della Loggia F, Mariani-Costantini R, Cama A.

Hum Mol Genet. 2000 Oct 12;9(17):2517-21.PMID: 11030756 [PubMed - indexed for MEDLINE]Related articlesFree article

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.

Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M.

Diabetes. 2001 Aug;50(8):1949-51.PMID: 11473060 [PubMed - indexed for MEDLINE]Related articlesFree article