PubMed

Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes.

Motzo C, Contu D, Cordell HJ, Lampis R, Congia M, Marrosu MG, Todd JA, Devoto M, Cucca F.

Diabetes. 2004 Dec;53(12):3286-91.PMID: 15561961 [PubMed - indexed for MEDLINE]Related articlesFree article

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler AG, Bonifacio E.

Diabetologia. 2003 May;46(5):712-20. Epub 2003 May 16.PMID: 12750767 [PubMed - indexed for MEDLINE]Related articles

Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.

Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC.

Diabetologia. 2008 Apr;51(4):589-96. Epub 2008 Feb 22.PMID: 18292987 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.

Cejkova P, Novota P, Cerna M, Kolostova K, Novakova D, Kucera P, Novak J, Andel M, Weber P, Zdarsky E.

Int J Immunogenet. 2008 Apr;35(2):133-40. Epub 2008 Feb 11.PMID: 18279373 [PubMed - indexed for MEDLINE]Related articles

Low frequency of HLA DRB1*03 - DQB1*02 and DQB1*0302 haplotypes in Romania is consistent with the country's low incidence of Type I diabetes.

Ionescu-Tîrgoviste C, Guja C, Herr M, Cucca E, Welsh K, Bunce M, Marshall S, Todd JA.

Diabetologia. 2001 Oct;44 Suppl 3:B60-6.PMID: 11724419 [PubMed - indexed for MEDLINE]Related articles

The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype.

Stene LC, Thorsby PM, Berg JP, Rønningen KS, Undlien DE, Joner G; Norwegian Childhood Diabetes Study Group.

Diabetologia. 2006 Sep;49(9):2068-73. Epub 2006 May 12.PMID: 16691379 [PubMed - indexed for MEDLINE]Related articles

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.

Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P; Type 1 Diabetes Genetics Consortium.

Diabetes. 2008 Apr;57(4):1084-92. Epub 2008 Feb 5.PMID: 18252895 [PubMed - indexed for MEDLINE]Related articlesFree article

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.

Koeleman BP, Lie BA, Undlien DE, Dudbridge F, Thorsby E, de Vries RR, Cucca F, Roep BO, Giphart MJ, Todd JA.

Genes Immun. 2004 Aug;5(5):381-8.PMID: 15164102 [PubMed - indexed for MEDLINE]Related articles

In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

Metcalfe KA, Hitman GA, Fennessy MJ, McCarthy MI, Tuomilehto J, Tuomilehto-Wolf E.

Diabetologia. 1995 Oct;38(10):1223-9.PMID: 8690176 [PubMed - indexed for MEDLINE]Related articles

Estimation of diabetes risk in Brazilian population by typing for polymorphisms in HLA-DR-DQ, INS and CTLA-4 genes.

Hauache OM, Reis AF, Oliveira CS, Vieira JG, Sjöroos M, Ilonen J.

Dis Markers. 2005;21(3):139-45.PMID: 16276008 [PubMed - indexed for MEDLINE]Related articles

Additive susceptibility to insulin-dependent diabetes conferred by HLA-DQB1 and insulin genes.

She JX, Bui MM, Tian XH, Muir A, Wakeland EK, Zorovich B, Zhang LP, Liu MC, Thomson G, Maclaren NK.

Autoimmunity. 1994;18(3):195-203.PMID: 7858104 [PubMed - indexed for MEDLINE]Related articles

An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Walker M, Gillespie KM, Bingley PJ, Hitman GA, Holman RR, McCarthy MI, Clark A.

Diabetologia. 2007 Jan;50(1):68-73. Epub 2006 Dec 2.PMID: 17143607 [PubMed - indexed for MEDLINE]Related articles

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J.

Tissue Antigens. 2007 Aug;70(2):110-27.PMID: 17610416 [PubMed - indexed for MEDLINE]Related articles

Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABFIN study).

Buzzetti R, Galgani A, Petrone A, Del Buono ML, Erlich HA, Bugawan TL, Lorini R, Meschi F, Multari G, Pozzilli P, Locatelli M, Bottazzo G, Di Mario U.

Diabetes Metab Res Rev. 2004 Mar-Apr;20(2):137-43.PMID: 15037989 [PubMed - indexed for MEDLINE]Related articles

Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype.

Petrone A, Galgani A, Spoletini M, Alemanno I, Di Cola S, Bassotti G, Picardi A, Manfrini S, Osborn J, Pozzilli P, Buzzetti R.

Diabetes Metab Res Rev. 2005 May-Jun;21(3):271-5.PMID: 15786423 [PubMed - indexed for MEDLINE]Related articles

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.

Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J.

Diabetologia. 2006 Jun;49(6):1198-208. Epub 2006 Apr 14.PMID: 16614815 [PubMed - indexed for MEDLINE]Related articles

Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom.

Lambert AP, Gillespie KM, Thomson G, Cordell HJ, Todd JA, Gale EA, Bingley PJ.

J Clin Endocrinol Metab. 2004 Aug;89(8):4037-43.PMID: 15292346 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs.

Al-Jenaidi FA, Wakim-Ghorayeb SF, Al-Abbasi A, Arekat MR, Irani-Hakime N, Najm P, Al-Ola K, Motala AA, Almawi WY.

J Clin Endocrinol Metab. 2005 Sep;90(9):5104-9. Epub 2005 Jun 28.PMID: 15985473 [PubMed - indexed for MEDLINE]Related articlesFree article

Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes.

Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Rewers M, Dabelea D.

Diabetes Care. 2008 Jul;31(7):1392-6. Epub 2008 Mar 20.PMID: 18356404 [PubMed - indexed for MEDLINE]Related articlesFree article

5' insulin gene polymorphism confers risk to IDDM independently of HLA class II susceptibility.

van der Auwera BJ, Heimberg H, Schrevens AF, van Waeyenberge C, Flament J, Schuit FC.

Diabetes. 1993 Jun;42(6):851-4.PMID: 8495808 [PubMed - indexed for MEDLINE]Related articles