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    Results: 1 to 20 of 171

    1.

    A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.

    Qureshi SA, Rios Candelore M, Xie D, Yang X, Tota LM, Ding VD, Li Z, Bansal A, Miller C, Cohen SM, Jiang G, Brady E, Saperstein R, Duffy JL, Tata JR, Chapman KT, Moller DE, Zhang BB.

    Diabetes. 2004 Dec;53(12):3267-73.PMID: 15561959 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.

    Parker JC, McPherson RK, Andrews KM, Levy CB, Dubins JS, Chin JE, Perry PV, Hulin B, Perry DA, Inagaki T, Dekker KA, Tachikawa K, Sugie Y, Treadway JL.

    Diabetes. 2000 Dec;49(12):2079-86.PMID: 11118010 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor.

    Cohen SM, Duffy JL, Miller C, Kirk BA, Candelore MR, Ding VD, Kaczorowski G, Tota LM, Werrmann JG, Wright M, Parmee ER, Tata JR, Zhang BB.

    Bioorg Med Chem. 2006 Mar 1;14(5):1506-17. Epub 2005 Oct 25.PMID: 16256355 [PubMed - indexed for MEDLINE]Related articles

    4.

    Somatostatin receptor subtype-2-deficient mice with diet-induced obesity have hyperglycemia, nonfasting hyperglucagonemia, and decreased hepatic glycogen deposition.

    Singh V, Grötzinger C, Nowak KW, Zacharias S, Göncz E, Pless G, Sauer IM, Eichhorn I, Pfeiffer-Guglielmi B, Hamprecht B, Wiedenmann B, Plöckinger U, Strowski MZ.

    Endocrinology. 2007 Aug;148(8):3887-99. Epub 2007 May 24.PMID: 17525126 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Cloning and expression of canine glucagon receptor and its use to evaluate glucagon receptor antagonists in vitro and in vivo.

    Yang X, Yates ML, Candelore MR, Feeney W, Hora D, Kim RM, Parmee ER, Berger JP, Zhang BB, Qureshi SA.

    Eur J Pharmacol. 2007 Jan 19;555(1):8-16. Epub 2006 Oct 21.PMID: 17140563 [PubMed - indexed for MEDLINE]Related articles

    6.

    Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor.

    Cascieri MA, Koch GE, Ber E, Sadowski SJ, Louizides D, de Laszlo SE, Hacker C, Hagmann WK, MacCoss M, Chicchi GG, Vicario PP.

    J Biol Chem. 1999 Mar 26;274(13):8694-7.PMID: 10085108 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Insulin inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically.

    Ikezawa Y, Yamatani K, Ohnuma H, Igarashi M, Daimon M, Manaka H, Sasaki H.

    J Lab Clin Med. 2001 Dec;138(6):387-92.PMID: 11753285 [PubMed - indexed for MEDLINE]Related articles

    8.

    Insulin inhibits glucagon-induced glycogenolysis normally in perivenous hepatocytes of Wistar fatty rats.

    Ikezawa Y, Yamatani K, Ohnuma H, Daimon M, Manaka H, Sasaki H.

    Diabetes Res Clin Pract. 2005 Aug;69(2):120-3.PMID: 16005360 [PubMed - indexed for MEDLINE]Related articles

    9.

    Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists.

    Dallas-Yang Q, Shen X, Strowski M, Brady E, Saperstein R, Gibson RE, Szalkowski D, Qureshi SA, Candelore MR, Fenyk-Melody JE, Parmee ER, Zhang BB, Jiang G.

    Eur J Pharmacol. 2004 Oct 6;501(1-3):225-34.PMID: 15464082 [PubMed - indexed for MEDLINE]Related articles

    10.

    Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels.

    Gysin B, Johnson DG, Trivedi D, Hruby VJ.

    J Med Chem. 1987 Aug;30(8):1409-15.PMID: 3039134 [PubMed - indexed for MEDLINE]Related articles

    11.

    Insulin-dependent inhibition of hepatic glycogenolysis by gastric inhibitory polypeptide (GIP) in perfused rat liver.

    Hartmann H, Ebert R, Creutzfeldt W.

    Diabetologia. 1986 Feb;29(2):112-4.PMID: 3516765 [PubMed - indexed for MEDLINE]Related articles

    12.

    Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys.

    Yan H, Gu W, Yang J, Bi V, Shen Y, Lee E, Winters KA, Komorowski R, Zhang C, Patel JJ, Caughey D, Elliott GS, Lau YY, Wang J, Li YS, Boone T, Lindberg RA, Hu S, Véniant MM.

    J Pharmacol Exp Ther. 2009 Apr;329(1):102-11. Epub 2009 Jan 7.PMID: 19129372 [PubMed - indexed for MEDLINE]Related articles

    13.

    Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor.

    Liang R, Abrardo L, Brady EJ, Candelore MR, Ding V, Saperstein R, Tota LM, Wright M, Mock S, Tamvakopolous C, Tong S, Zheng S, Zhang BB, Tata JR, Parmee ER.

    Bioorg Med Chem Lett. 2007 Feb 1;17(3):587-92. Epub 2006 Nov 10.PMID: 17126016 [PubMed - indexed for MEDLINE]Related articles

    14.

    Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.

    Unson CG, Gurzenda EM, Merrifield RB.

    Peptides. 1989 Nov-Dec;10(6):1171-7.PMID: 2560175 [PubMed - indexed for MEDLINE]Related articles

    15.

    Discovery of potent, orally active benzimidazole glucagon receptor antagonists.

    Kim RM, Chang J, Lins AR, Brady E, Candelore MR, Dallas-Yang Q, Ding V, Dragovic J, Iliff S, Jiang G, Mock S, Qureshi S, Saperstein R, Szalkowski D, Tamvakopoulos C, Tota L, Wright M, Yang X, Tata JR, Chapman K, Zhang BB, Parmee ER.

    Bioorg Med Chem Lett. 2008 Jul 1;18(13):3701-5. Epub 2008 May 22.PMID: 18539028 [PubMed - indexed for MEDLINE]Related articles

    16.

    Effects of glucagon on glycogenolysis and gluconeogenesis are region-specific in periportal and perivenous hepatocytes.

    Ikezawa Y, Yamatani K, Ogawa A, Ohnuma H, Igarashi M, Daimon M, Manaka H, Sasaki H.

    J Lab Clin Med. 1998 Dec;132(6):547-55.PMID: 9851746 [PubMed - indexed for MEDLINE]Related articles

    17.

    Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

    Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J.

    J Med Chem. 2008 Sep 11;51(17):5387-96. Epub 2008 Aug 16.PMID: 18707090 [PubMed - indexed for MEDLINE]Related articles

    18.

    Glucagon-like peptide-1 inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically.

    Ikezawa Y, Yamatani K, Ohnuma H, Daimon M, Manaka H, Sasaki H.

    Regul Pept. 2003 Mar 28;111(1-3):207-10.PMID: 12609770 [PubMed - indexed for MEDLINE]Related articles

    19.

    Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

    Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT.

    Diabetes. 2004 Feb;53(2):410-7.PMID: 14747292 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.

    Shen DM, Zhang F, Brady EJ, Candelore MR, Dallas-Yang Q, Ding VD, Dragovic J, Feeney WP, Jiang G, McCann PE, Mock S, Qureshi SA, Saperstein R, Shen X, Tamvakopoulos C, Tong X, Tota LM, Wright MJ, Yang X, Zheng S, Chapman KT, Zhang BB, Tata JR, Parmee ER.

    Bioorg Med Chem Lett. 2005 Oct 15;15(20):4564-9.PMID: 16102966 [PubMed - indexed for MEDLINE]Related articles

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