PubMed

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Cleasby ME, Dzamko N, Hegarty BD, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Dec;53(12):3258-66.PMID: 15561958 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin.

Ye JM, Dzamko N, Cleasby ME, Hegarty BD, Furler SM, Cooney GJ, Kraegen EW.

Diabetologia. 2004 Jul;47(7):1306-13. Epub 2004 Jul 1.PMID: 15232684 [PubMed - indexed for MEDLINE]Related articles

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver.

Ye JM, Frangioudakis G, Iglesias MA, Furler SM, Ellis B, Dzamko N, Cooney GJ, Kraegen EW.

Endocrinology. 2002 Dec;143(12):4527-35.PMID: 12446579 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.

Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW.

Diabetes. 1997 Nov;46(11):1768-74.PMID: 9356024 [PubMed - indexed for MEDLINE]Related articles

Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.

Park E, Wong V, Guan X, Oprescu AI, Giacca A.

J Endocrinol. 2007 Nov;195(2):323-31.PMID: 17951543 [PubMed - indexed for MEDLINE]Related articlesFree article

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues.

Watt MJ, Hevener A, Lancaster GI, Febbraio MA.

Endocrinology. 2006 May;147(5):2077-85. Epub 2006 Jan 5.PMID: 16396984 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA.

J Biol Chem. 2004 Nov 12;279(46):47898-905. Epub 2004 Sep 14.PMID: 15371448 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.

Hevener AL, Reichart D, Janez A, Olefsky J.

Diabetes. 2001 Oct;50(10):2316-22.PMID: 11574414 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.PMID: 16234268 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

Hoy AJ, Brandon AE, Turner N, Watt MJ, Bruce CR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E67-75. Epub 2009 Apr 14.PMID: 19366875 [PubMed - indexed for MEDLINE]Related articles

S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats.

Sohn KA, Cruciani-Guglielmacci C, Kassis N, Clément L, Ouali F, Caüzac M, Lebègue N, Berthelot P, Caignard DH, Pégorier JP, Renard P, Dacquet C, Ktorza A, Magnan C; Consortium of the French Ministry of Research and Technology.

Eur J Pharmacol. 2009 Apr 17;608(1-3):104-11. Epub 2009 Feb 26.PMID: 19250932 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.

Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91.PMID: 12217885 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.

Itani SI, Ruderman NB, Schmieder F, Boden G.

Diabetes. 2002 Jul;51(7):2005-11.PMID: 12086926 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH.

Diabetes. 2009 Jan;58(1):116-24. Epub 2008 Oct 24.PMID: 18952837 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin.

Song S, Andrikopoulos S, Filippis C, Thorburn AW, Khan D, Proietto J.

Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.PMID: 11440903 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes.

Basu R, Basu A, Chandramouli V, Norby B, Dicke B, Shah P, Cohen O, Landau BR, Rizza RA.

Diabetologia. 2008 Nov;51(11):2031-40. Epub 2008 Sep 4.PMID: 18769904 [PubMed - indexed for MEDLINE]Related articlesFree article

Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion.

Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Höer NF, Boschero AC, Saad MJ.

Endocrinology. 2005 Mar;146(3):1576-87. Epub 2004 Dec 9.PMID: 15591151 [PubMed - indexed for MEDLINE]Related articlesFree article

High-fat- and lipid-induced insulin resistance in rats: the comparison of glucose metabolism, plasma resistin and adiponectin levels.

Li L, Yang G, Li Q, Tang Y, Li K.

Ann Nutr Metab. 2006;50(6):499-505. Epub 2006 Dec 21.PMID: 17191023 [PubMed - indexed for MEDLINE]Related articles

Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes.

Tiikkainen M, Häkkinen AM, Korsheninnikova E, Nyman T, Mäkimattila S, Yki-Järvinen H.

Diabetes. 2004 Aug;53(8):2169-76.PMID: 15277403 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A.

Tsintzas K, Chokkalingam K, Jewell K, Norton L, Macdonald IA, Constantin-Teodosiu D.

J Clin Endocrinol Metab. 2007 Oct;92(10):3967-72. Epub 2007 Jul 24.PMID: 17652214 [PubMed - indexed for MEDLINE]Related articlesFree article