PubMed

Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1.

Majumdar G, Wright J, Markowitz P, Martinez-Hernandez A, Raghow R, Solomon SS.

Diabetes. 2004 Dec;53(12):3184-92.PMID: 15561949 [PubMed - indexed for MEDLINE]Related articlesFree article

O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon.

Majumdar G, Harmon A, Candelaria R, Martinez-Hernandez A, Raghow R, Solomon SS.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E584-91.PMID: 12900380 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells.

Majumdar G, Harrington A, Hungerford J, Martinez-Hernandez A, Gerling IC, Raghow R, Solomon S.

J Biol Chem. 2006 Feb 10;281(6):3642-50. Epub 2005 Dec 6.PMID: 16332679 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of O-linked beta-N-acetylglucosamine modification in the subcellular distribution of alpha4 phosphoprotein and Sp1 in rat lymphoma cells.

Dauphinee SM, Ma M, Too CK.

J Cell Biochem. 2005 Oct 15;96(3):579-88.PMID: 16052526 [PubMed - indexed for MEDLINE]Related articles

Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.

Konrad RJ, Zhang F, Hale JE, Knierman MD, Becker GW, Kudlow JE.

Biochem Biophys Res Commun. 2002 Apr 26;293(1):207-12.PMID: 12054585 [PubMed - indexed for MEDLINE]Related articles

Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat.

Pan X, Solomon SS, Borromeo DM, Martinez-Hernandez A, Raghow R.

Endocrinology. 2001 Apr;142(4):1635-42.PMID: 11250945 [PubMed - indexed for MEDLINE]Related articlesFree article

O-linked N-acetylglucosaminylation of Sp1 inhibits the human immunodeficiency virus type 1 promoter.

Jochmann R, Thurau M, Jung S, Hofmann C, Naschberger E, Kremmer E, Harrer T, Miller M, Schaft N, Stürzl M.

J Virol. 2009 Apr;83(8):3704-18. Epub 2009 Feb 4.PMID: 19193796 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased O-GlcNAc transferase in pancreas of rats with streptozotocin-induced diabetes.

Akimoto Y, Kreppel LK, Hirano H, Hart GW.

Diabetologia. 2000 Oct;43(10):1239-47.PMID: 11079742 [PubMed - indexed for MEDLINE]Related articles

Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells.

Goldberg HJ, Whiteside CI, Hart GW, Fantus IG.

Endocrinology. 2006 Jan;147(1):222-31. Erratum in: Endocrinology. 2006 Nov;147(11):5490. PMID: 16365142 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the O-linked N-acetylglucosamine transferase in rat pancreas.

Akimoto Y, Kreppel LK, Hirano H, Hart GW.

Diabetes. 1999 Dec;48(12):2407-13.PMID: 10580430 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats.

Akimoto Y, Hart GW, Wells L, Vosseller K, Yamamoto K, Munetomo E, Ohara-Imaizumi M, Nishiwaki C, Nagamatsu S, Hirano H, Kawakami H.

Glycobiology. 2007 Feb;17(2):127-40. Epub 2006 Nov 9.PMID: 17095531 [PubMed - indexed for MEDLINE]Related articlesFree article

Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.

Roos MD, Xie W, Su K, Clark JA, Yang X, Chin E, Paterson AJ, Kudlow JE.

Proc Assoc Am Physicians. 1998 Sep-Oct;110(5):422-32.PMID: 9756093 [PubMed - indexed for MEDLINE]Related articles

O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.

Yang X, Su K, Roos MD, Chang Q, Paterson AJ, Kudlow JE.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6611-6. Epub 2001 May 22.PMID: 11371615 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential regulation of nuclear UDP-N-acetylglucosaminyl transferase (OGT) by substrate availability: ability of chromatin protein to bind UDP-N-acetylglucosamine and reduce OGT-mediated O-Linked glycosylation.

Okuyama R, Marshall S.

Biol Pharm Bull. 2004 Aug;27(8):1293-6.PMID: 15305040 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.

Taylor RP, Parker GJ, Hazel MW, Soesanto Y, Fuller W, Yazzie MJ, McClain DA.

J Biol Chem. 2008 Mar 7;283(10):6050-7. Epub 2008 Jan 3.PMID: 18174169 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcription.

Kamemura K, Hart GW.

Prog Nucleic Acid Res Mol Biol. 2003;73:107-36. Review.PMID: 12882516 [PubMed - indexed for MEDLINE]Related articles

Paradoxical regulation of Sp1 transcription factor by glucagon.

Keembiyehetty CN, Candelaria RP, Majumdar G, Raghow R, Martinez-Hernandez A, Solomon SS.

Endocrinology. 2002 Apr;143(4):1512-20.PMID: 11897710 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation.

Clark RJ, McDonough PM, Swanson E, Trost SU, Suzuki M, Fukuda M, Dillmann WH.

J Biol Chem. 2003 Nov 7;278(45):44230-7. Epub 2003 Aug 26.PMID: 12941958 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.

Fülöp N, Mason MM, Dutta K, Wang P, Davidoff AJ, Marchase RB, Chatham JC.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1370-8. Epub 2006 Nov 29.PMID: 17135297 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of O-linked protein glycosylation in beta-cell dysfunction.

Konrad RJ, Kudlow JE.

Int J Mol Med. 2002 Nov;10(5):535-9. Review.PMID: 12373287 [PubMed - indexed for MEDLINE]Related articles