PubMed

High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells.

Cao LZ, Tang DQ, Horb ME, Li SW, Yang LJ.

Diabetes. 2004 Dec;53(12):3168-78.PMID: 15561947 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation.

Tang DQ, Cao LZ, Chou W, Shun L, Farag C, Atkinson MA, Li SW, Chang LJ, Yang LJ.

Lab Invest. 2006 Aug;86(8):829-41. Epub 2006 May 29.PMID: 16732298 [PubMed - indexed for MEDLINE]Related articlesFree article

Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors.

Tang DQ, Lu S, Sun YP, Rodrigues E, Chou W, Yang C, Cao LZ, Chang LJ, Yang LJ.

Lab Invest. 2006 Jan;86(1):83-93.PMID: 16294197 [PubMed - indexed for MEDLINE]Related articlesFree article

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach.

Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, Karnieli E.

Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.PMID: 17131142 [PubMed - indexed for MEDLINE]Related articles

Conversion of immortal liver progenitor cells into pancreatic endocrine progenitor cells by persistent expression of Pdx-1.

Jin CX, Li WL, Xu F, Geng ZH, He ZY, Su J, Tao XR, Ding XY, Wang X, Hu YP.

J Cell Biochem. 2008 May 1;104(1):224-36.PMID: 17979180 [PubMed - indexed for MEDLINE]Related articles

Liver stem cell-derived beta-cell surrogates for treatment of type 1 diabetes.

Yang LJ.

Autoimmun Rev. 2006 Jul;5(6):409-13. Epub 2005 Dec 22. Review.PMID: 16890895 [PubMed - indexed for MEDLINE]Related articles

Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method.

Lin HT, Kao CL, Lee KH, Chang YL, Chiou SH, Tsai FT, Tsai TH, Sheu DC, Ho LL, Ku HH.

World J Gastroenterol. 2007 Mar 21;13(11):1672-9.PMID: 17461469 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.

Zalzman M, Gupta S, Giri RK, Berkovich I, Sappal BS, Karnieli O, Zern MA, Fleischer N, Efrat S.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7253-8. Epub 2003 May 19.PMID: 12756298 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro transdifferentiation of hepatoma cells into functional pancreatic cells.

Li WC, Horb ME, Tosh D, Slack JM.

Mech Dev. 2005 Jun;122(6):835-47. Epub 2005 Feb 17.PMID: 15939230 [PubMed - indexed for MEDLINE]Related articles

Experimental conversion of liver to pancreas.

Horb ME, Shen CN, Tosh D, Slack JM.

Curr Biol. 2003 Jan 21;13(2):105-15.PMID: 12546783 [PubMed - indexed for MEDLINE]Related articles

Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice.

Zhao M, Amiel SA, Christie MR, Rela M, Heaton N, Huang GC.

Diabetologia. 2005 Oct;48(10):2051-61. Epub 2005 Aug 17.PMID: 16132961 [PubMed - indexed for MEDLINE]Related articles

Heterogeneity in predisposition of hepatic cells to be induced into pancreatic endocrine cells by PDX-1.

Lu S, Wang WP, Wang XF, Zheng ZM, Chen P, Ma KT, Zhou CY.

World J Gastroenterol. 2005 Apr 21;11(15):2277-82.PMID: 15818739 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro transdifferentiation of mature hepatocytes into insulin-producing cells.

Yamada S, Yamamoto Y, Nagasawa M, Hara A, Kodera T, Kojima I.

Endocr J. 2006 Dec;53(6):789-95. Epub 2006 Sep 19.PMID: 16983179 [PubMed - indexed for MEDLINE]Related articlesFree article

Maturation of adult beta-cells revealed using a Pdx1/insulin dual-reporter lentivirus.

Szabat M, Luciani DS, Piret JM, Johnson JD.

Endocrinology. 2009 Apr;150(4):1627-35. Epub 2008 Dec 18.PMID: 19095744 [PubMed - indexed for MEDLINE]Related articles

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells.

Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC.

J Endocrinol. 2009 Apr;201(1):37-47. Epub 2009 Jan 23.PMID: 19168505 [PubMed - indexed for MEDLINE]Related articles

The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells.

Lavon N, Yanuka O, Benvenisty N.

Stem Cells. 2006 Aug;24(8):1923-30. Epub 2006 May 4.PMID: 16675598 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy.

Koya V, Lu S, Sun YP, Purich DL, Atkinson MA, Li SW, Yang LJ.

Diabetes. 2008 Mar;57(3):757-69. Epub 2007 Dec 17.PMID: 18086901 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells.

Delisle JC, Martignat L, Dubreil L, Saï P, Bach JM, Louzier V, Bösch S.

BMC Res Notes. 2009 Jan 9;2:3.PMID: 19134185 [PubMed - in process]Related articlesFree article

PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance.

Kaneto H, Nakatani Y, Miyatsuka T, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y.

Diabetes. 2005 Apr;54(4):1009-22.PMID: 15793239 [PubMed - indexed for MEDLINE]Related articlesFree article

In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors.

Motoyama H, Ogawa S, Kubo A, Miwa S, Nakayama J, Tagawa Y, Miyagawa S.

Biochem Biophys Res Commun. 2009 Jul 17;385(1):123-8. Epub 2009 May 5.PMID: 19422803 [PubMed - indexed for MEDLINE]Related articles