PubMed

Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents.

Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T.

Diabetes. 2004 Dec;53(12):3142-51.PMID: 15561944 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin.

Dezaki K, Kakei M, Yada T.

Diabetes. 2007 Sep;56(9):2319-27. Epub 2007 Jun 15.PMID: 17575083 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential.

Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M.

Curr Diabetes Rev. 2008 Feb;4(1):18-23. Review.PMID: 18220691 [PubMed - indexed for MEDLINE]Related articles

Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.

Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T.

Diabetes. 2006 Dec;55(12):3486-93.PMID: 17130496 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis.

Dezaki K, Sone H, Yada T.

Pharmacol Ther. 2008 May;118(2):239-49. Epub 2008 Mar 10. Review.PMID: 18433874 [PubMed - indexed for MEDLINE]Related articles

Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice.

Salehi A, Dornonville de la Cour C, Håkanson R, Lundquist I.

Regul Pept. 2004 May 15;118(3):143-50.PMID: 15003830 [PubMed - indexed for MEDLINE]Related articles

Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans.

Kim SW, Kim KW, Shin CS, Park do J, Park KS, Cho BY, Lee HK, Kim SY.

Horm Res. 2007;67(5):211-9. Epub 2006 Nov 16.PMID: 17114888 [PubMed - indexed for MEDLINE]Related articles

Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets.

Colombo M, Gregersen S, Xiao J, Hermansen K.

Pancreas. 2003 Aug;27(2):161-6.PMID: 12883265 [PubMed - indexed for MEDLINE]Related articles

Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion.

Egido EM, Rodriguez-Gallardo J, Silvestre RA, Marco J.

Eur J Endocrinol. 2002 Feb;146(2):241-4.PMID: 11834435 [PubMed - indexed for MEDLINE]Related articlesFree article

Morphological analysis of ghrelin and its receptor distribution in the rat pancreas.

Kageyama H, Funahashi H, Hirayama M, Takenoya F, Kita T, Kato S, Sakurai J, Lee EY, Inoue S, Date Y, Nakazato M, Kangawa K, Shioda S.

Regul Pept. 2005 Mar 15;126(1-2):67-71.PMID: 15620416 [PubMed - indexed for MEDLINE]Related articles

Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.

Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2004 May;286(5):E834-43. Epub 2004 Jan 21.PMID: 14736703 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.

Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):885-90. Epub 2006 Jan 17.PMID: 16418280 [PubMed - indexed for MEDLINE]Related articlesFree article

Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents.

Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT.

Endocrinology. 2007 Apr;148(4):1648-53. Epub 2007 Jan 4.PMID: 17204551 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.

Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S.

Diabetes. 2002 Jan;51(1):124-9.PMID: 11756331 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells.

Wierup N, Yang S, McEvilly RJ, Mulder H, Sundler F.

J Histochem Cytochem. 2004 Mar;52(3):301-10.PMID: 14966197 [PubMed - indexed for MEDLINE]Related articlesFree article

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.

Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat T, Van Der Lely AJ, Ghigo E.

J Clin Endocrinol Metab. 2004 Jun;89(6):3062-5.PMID: 15181099 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion.

Hopcroft DW, Mason DR, Scott RS.

Endocrinology. 1985 Nov;117(5):2073-80.PMID: 2864239 [PubMed - indexed for MEDLINE]Related articles

Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH Pulse amplitude: evidence from antagonism of the GH secretagogue-R1a receptor.

Zizzari P, Halem H, Taylor J, Dong JZ, Datta R, Culler MD, Epelbaum J, Bluet-Pajot MT.

Endocrinology. 2005 Sep;146(9):3836-42. Epub 2005 May 26.PMID: 15919752 [PubMed - indexed for MEDLINE]Related articlesFree article

Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.

Toshinai K, Yamaguchi H, Sun Y, Smith RG, Yamanaka A, Sakurai T, Date Y, Mondal MS, Shimbara T, Kawagoe T, Murakami N, Miyazato M, Kangawa K, Nakazato M.

Endocrinology. 2006 May;147(5):2306-14. Epub 2006 Feb 16.PMID: 16484324 [PubMed - indexed for MEDLINE]Related articlesFree article