PubMed

Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes.

Lu Y, Herrera PL, Guo Y, Sun D, Tang Z, LeRoith D, Liu JL.

Diabetes. 2004 Dec;53(12):3131-41.PMID: 15561943 [PubMed - indexed for MEDLINE]Related articlesFree article

Does IGF-I stimulate pancreatic islet cell growth?

Liu JL.

Cell Biochem Biophys. 2007;48(2-3):115-25.PMID: 17709881 [PubMed - indexed for MEDLINE]Related articles

Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas.

Lu Y, Ponton A, Okamoto H, Takasawa S, Herrera PL, Liu JL.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E50-8. Epub 2006 Jan 31.PMID: 16449294 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice.

Guo Y, Lu Y, Houle D, Robertson K, Tang Z, Kopchick JJ, Liu YL, Liu JL.

Endocrinology. 2005 Jun;146(6):2602-9. Epub 2005 Feb 24.PMID: 15731363 [PubMed - indexed for MEDLINE]Related articlesFree article

A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes.

Robertson K, Lu Y, De Jesus K, Li B, Su Q, Lund PK, Liu JL.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E928-38. Epub 2008 Feb 12.PMID: 18270301 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.PMID: 15769793 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of hypophysectomy on pancreatic islet hormone and insulin-like growth factor I content and mRNA expression in rat.

Jevdjovic T, Maake C, Zwimpfer C, Krey G, Eppler E, Zapf J, Reinecke M.

Histochem Cell Biol. 2005 Feb;123(2):179-88. Epub 2005 Apr 6.PMID: 15812646 [PubMed - indexed for MEDLINE]Related articles

Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance.

Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL.

Mol Cell Endocrinol. 2003 Jun 30;204(1-2):31-42.PMID: 12850279 [PubMed - indexed for MEDLINE]Related articles

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets.

Hill DJ, Strutt B, Arany E, Zaina S, Coukell S, Graham CF.

Endocrinology. 2000 Mar;141(3):1151-7.PMID: 10698192 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.

J Clin Invest. 2000 Mar;105(6):731-40.PMID: 10727441 [PubMed - indexed for MEDLINE]Related articlesFree article

Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.

Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L.

Mol Cell Biol. 2007 Sep;27(17):6026-37. Epub 2007 Jun 18. Erratum in: Mol Cell Biol. 2007 Oct;27(20):7354. PMID: 17576812 [PubMed - indexed for MEDLINE]Related articlesFree article

A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II.

Petrik J, Reusens B, Arany E, Remacle C, Coelho C, Hoet JJ, Hill DJ.

Endocrinology. 1999 Oct;140(10):4861-73.PMID: 10499546 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of IGF-I in pancreatic islets prevents lymphocytic infiltration and protects mice from type 1 diabetes.

Casellas A, Salavert A, Agudo J, Ayuso E, Jimenez V, Moya M, Muñoz S, Franckhauser S, Bosch F.

Diabetes. 2006 Dec;55(12):3246-55.PMID: 17130467 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.

Petrik J, Pell JM, Arany E, McDonald TJ, Dean WL, Reik W, Hill DJ.

Endocrinology. 1999 May;140(5):2353-63.PMID: 10218989 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

Agudo J, Ayuso E, Jimenez V, Salavert A, Casellas A, Tafuro S, Haurigot V, Ruberte J, Segovia JC, Bueren J, Bosch F.

Diabetologia. 2008 Oct;51(10):1862-72. Epub 2008 Jul 29.PMID: 18663428 [PubMed - indexed for MEDLINE]Related articles

Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice.

Robertson K, Kopchick JJ, Liu JL.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E491-8. Epub 2006 Apr 18.PMID: 16621895 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.PMID: 15194489 [PubMed - indexed for MEDLINE]Related articles

Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

George M, Ayuso E, Casellas A, Costa C, Devedjian JC, Bosch F.

J Clin Invest. 2002 May;109(9):1153-63.PMID: 11994404 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

Diabetes. 2001 May;50(5):1110-8.PMID: 11334415 [PubMed - indexed for MEDLINE]Related articlesFree article