PubMed

The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells.

Emanuelli B, Glondu M, Filloux C, Peraldi P, Van Obberghen E.

Diabetes. 2004 Dec;53 Suppl 3:S97-S103.PMID: 15561930 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells.

Kwon G, Corbett JA, Hauser S, Hill JR, Turk J, McDaniel ML.

Diabetes. 1998 Apr;47(4):583-91.PMID: 9568691 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2004 Nov;47(11):1998-2011. Epub 2004 Dec 2.PMID: 15578154 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA.

J Biol Chem. 2003 Apr 18;278(16):13740-6. Epub 2003 Jan 30.PMID: 12560330 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3.

Wu X, Herndon DN, Wolf SE.

Shock. 2003 Apr;19(4):314-20.PMID: 12688541 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.

Ueki K, Kondo T, Kahn CR.

Mol Cell Biol. 2004 Jun;24(12):5434-46. Erratum in: Mol Cell Biol. 2005 Oct;25(19):8762. PMID: 15169905 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.

Chong MM, Thomas HE, Kay TW.

J Biol Chem. 2002 Aug 2;277(31):27945-52. Epub 2002 May 24.PMID: 12032139 [PubMed - indexed for MEDLINE]Related articlesFree article

SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma.

Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B.

J Biol Chem. 2001 Jul 13;276(28):25862-70. Epub 2001 May 7.PMID: 11342558 [PubMed - indexed for MEDLINE]Related articlesFree article

Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase.

Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T.

Diabetes. 1998 Oct;47(10):1602-8.PMID: 9753298 [PubMed - indexed for MEDLINE]Related articlesFree article

A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism.

Corbett JA, Sweetland MA, Lancaster JR Jr, McDaniel ML.

FASEB J. 1993 Feb 1;7(2):369-74.PMID: 8440413 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.

Hong TP, Andersen NA, Nielsen K, Karlsen AE, Fantuzzi G, Eizirik DL, Dinarello CA, Mandrup-Poulsen T.

Eur Cytokine Netw. 2000 Jun;11(2):193-205.PMID: 10903798 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines.

Santangelo C, Scipioni A, Marselli L, Marchetti P, Dotta F.

Eur J Endocrinol. 2005 Mar;152(3):485-9.PMID: 15757867 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide.

Arafat HA, Katakam AK, Chipitsyna G, Gong Q, Vancha AR, Gabbeta J, Dafoe DC.

Endocrinology. 2007 Feb;148(2):575-84. Epub 2006 Nov 16.PMID: 17110428 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells.

Boisclair YR, Wang J, Shi J, Hurst KR, Ooi GT.

J Biol Chem. 2000 Feb 11;275(6):3841-7.PMID: 10660535 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein induction in islets of Langerhans and insulinoma cells.

Laychock SG, Duzen J, Simpkins CO.

Mol Cell Endocrinol. 2000 Jul 25;165(1-2):179-87.PMID: 10940496 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells.

Chen MC, Paez-Espinosa V, Welsh N, Eizirik DL.

Endocrinology. 2000 Aug;141(8):2822-8.PMID: 10919268 [PubMed - indexed for MEDLINE]Related articlesFree article

Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation.

Kim EK, Kwon KB, Song MY, Han MJ, Lee JH, Lee YR, Lee JH, Ryu DG, Park BH, Park JW.

Pancreas. 2007 Nov;35(4):e1-9.PMID: 18090225 [PubMed - indexed for MEDLINE]Related articles

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells.

Laubner K, Kieffer TJ, Lam NT, Niu X, Jakob F, Seufert J.

Diabetes. 2005 Dec;54(12):3410-7.PMID: 16306356 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells.

Jacobsen ML, Rønn SG, Bruun C, Larsen CM, Eizirik DL, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2009 Feb;52(2):281-8. Epub 2008 Nov 11.PMID: 19002429 [PubMed - indexed for MEDLINE]Related articles